Variability in Working Memory Performance Explained by Epistasis vs Polygenic Scores in the ZNF804A Pathway

Autor: Nicodemus, Kk, Hargreaves, A, Morris, D, Anney, R, Gill, M, Corvin, A, Donohoe, G, Ripke, S, Sanders, Ar, Kendler, Ks, Levinson, Df, Sklar, P, Holmans, Pa, Lin, Dy, Duan, J, Ophoff, Ra, Andreassen, Oa, Scolnick, E, Cichon, S, Clair, St, D, Gurling, H, Werge, T, Rujescu, D, Blackwood, Dh, Pato, Cn, Malhotra, Ak, Purcell, S, Dudbridge, F, Neale, Bm, Rossin, L, Visscher, Pm, Posthuma, D, Ruderfer, Dm, Fanous, A, Stefansson, H, Steinberg, S, Mowry, Bj, Golimbet, V, Hert, De, M, Jönsson, Eg, Bitter, I, Pietiläinen, Op, Collier, Da, Tosato, Sarah, Agartz, I, Albus, M, Alexander, M, Amdur, Rl, Amin, F, Bass, N, Bergen, Se, Black, Dw, Børglum, Ad, Brown, Ma, Bruggeman, R, Buccola, Ng, Byerley, Wf, Cahn, W, Cantor, Rm, Carr, Vj, Catts, Sv, Choudhury, K, Cloninger, C, Cormican, P, Craddock, N, Danoy, Pa, Datta, S, Haan, De, L, Demontis, D, Dikeos, D, Djurovic, S, Donnelly, P, Duong, L, Dwyer, S, Fink Jensen, A, Freedman, R, Freimer, Nb, Friedl, M, Georgieva, L, Giegling, I, Glenthøj, B, Godard, S, Hamshere, M, Hansen, M, Hansen, T, Hartmann, Am, Henskens, Fa, Hougaard, Dm, Hultman, Cm, Ingason, A, Jablensky, Av, Jakobsen, Kd, Jay, M, Jürgens, G, Kahn, Rs, Keller, Mc, Kenis, G, Kenny, E, Kim, Y, Kirov, Gk, Konnerth, H, Konte, B, Krabbendam, L, Krasucki, R, Lasseter, Vk, Laurent, C, Lawrence, J, Lencz, T, Lerer, F, Liang, Ky, Lichtenstein, P, Lieberman, Ja, Linszen, Dh, Lönnqvist, J, Loughland, Cm, Maclean, Aw, Maher, Bs, Maier, W, Mallet, J, Malloy, P, Mattheisen, M, Mattingsdal, M, Mcghee, Ka, Mcgrath, Jj, Mcintosh, A, Mclean, De, Mcquillin, A, Melle, I, Michie, Pt, Milanova, V, Morris, Dw, Mors, O, Mortensen, Pb, Moskvina, V, Muglia, P, Myin Germeys, I, Nertney, Da, Nestadt, G, Nielsen, J, Nikolov, I, Nordentoft, M, Norton, N, Nöthen, Mm, O'Dushlaine, Ct, Olincy, A, Olsen, L, O'Neill, F, Ørntoft, Tf, Owen, Mj, Pantelis, C, Papadimitriou, G, Pato, Mt, Peltonen, L, Petursson, H, Pickard, B, Pimm, J, Pulver, Ae, Puri, V, Quested, D, Quinn, Em, Rasmussen, Hb, Réthelyi, Jm, Ribble, R, Rietschel, M, Riley, Bp, Ruggeri, Mirella, Schall, U, Schulze, Tg, Schwab, Sg, Scott, Rj, Shi, J, Sigurdsson, E, Silverman, Jm, Spencer, Cc, Stefansson, K, Strange, A, Strengman, E, Stroup, T, Suvisaari, J, Terenius, L, Thirumalai, S, Thygesen, Jh, Timm, S, Toncheva, D, Van, Den, Oord, E, Van, Os, Van, J, Winkel, R, Veldink, J, Walsh, D, Wang, Ag, Wiersma, D, Wildenauer, Db, Williams, Hj, Williams, Nm, Wormley, B, Zammit, S, Sullivan, Pf, O'Donovan, Mc, Daly, Mj, Gejman, P.

Publikováno v: Journal of the American Academy of Child and Adolescent Psychiatry, 71(7), 778-785. Elsevier Limited
Nicodemus, K K, Hargreaves, A, Morris, D, Anney, R, Gill, M, Corvin, A, Donohoe, G & Schizophrenia Psychiatric Genome-wide Association Study (GWAS) Consortium 2014, ' Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway ', J A M A Psychiatry, vol. 71, no. 7, pp. 778-85 . https://doi.org/10.1001/jamapsychiatry.2014.528
JAMA psychiatry, vol 71, iss 7
Nicodemus, K K, Hargreaves, A, Morris, D, Anney, R, Gill, M, Corvin, A, Posthuma, D & Donohoe, G 2014, ' Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway. ', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 71, no. 7, pp. 778-785 . https://doi.org/10.1001/jamapsychiatry.2014.528
JAMA Psychiatry, 71(7), 778-785. American Medical Association
JAMA psychiatry, 71(7), 778-785. American Medical Association

IMPORTANCE We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), polygenic scores, and epistatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e597267adcf8243757fe951af9a47a
https://doi.org/10.1001/jamapsychiatry.2014.528

Large recurrent microdeletions associated with schizophrenia

Autor: Toulopoulou, T, Franke, B, Crombie, C, Fossdal, R, Sigmundsson, T, BuizerVoskamp, JE, Hansen, T, Jakobsen, KD, Muglia, P, Francks, C, Matthews, PM, Murray, R, Ruggeri, M, Sabatti, C, Gylfason, A, Halldorsson, BV, Vassos, E, Tosato, S, Walshe, M, Freimer, NB, Gulcher, JR, Gudbjartsson, D, Thorsteinsdottir, U, Kong, A, Thorgeirsson, TE, Olesen, J, Vasilescu, C, Andreassen, OA, Melle, I, Mühleisen, TW, Wang, AG, Ullum, H, Need, AC, Sigurdsson, A, Jonasdottir, A, Djurovic, S, Ophoff, RA, Georgi, A, Rietschel, M, Werge, T, Bjornsson, A, Mattiasdottir, S, Blondal, T, Haraldsson, M, Petursson, H, MyinGermeys, I, Krabbendam, L, De Haan, L, Cahn, W, Bruggeman, R, Wiersma, D, Goldstein, DB, Nöthen, MM, Peltonen, L, Van Os, J, Linszen, DH, Kahn, RS, Stefansson, K, Magnusdottir, BB, Di Forti, M, Bramon, E, Paunio, T, TuulioHenriksson, A, Giegling, I, Möller, HJ, Suvisaari, J, Hartmann, A, Shianna, KV, Ge, D, Lonnqvist, J, Collier, DA, Walker, N, Li, T, Fraser, G, Ingason, A, Steinberg, S, Sigurdsson, E, St Clair, D, Kiemeney, LA, Stefansson, H, Rujescu, D, Cichon, S, Pietiläinen, OPH

Publikováno v: Nature, 455, 7210, pp. 232-6
Nature, 455, 232-6
Nature, 455(7210), 232-236. Nature Publishing Group

Reduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common variants have not been found that confer risk of disorders such as autism, schizophrenia and mental re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe93dab86948eaa9355e125d23ef45b
http://hdl.handle.net/10722/141844

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Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness.

Autor: Ingason A, Kirov G, Giegling I, Hansen T, Isles AR, Jakobsen KD, Kristinsson KT, le Roux L, Gustafsson O, Craddock N, Möller HJ, McQuillin A, Muglia P, Cichon S, Rietschel M, Ophoff RA, Djurovic S, Andreassen OA, Pietiläinen OP, Peltonen L

Publikováno v: American Journal of Psychiatry; Apr2011, Vol. 168 Issue 4, p408-417, 10p

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