Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jakob Zierk"'
Autor:
Tatjana Ammer, André Schützenmeister, Hans-Ulrich Prokosch, Manfred Rauh, Christopher M. Rank, Jakob Zierk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Reference intervals are essential for interpreting laboratory test results. Continuous reference intervals precisely capture physiological age-specific dynamics that occur throughout life, and thus have the potential to improve clinical deci
Externí odkaz:
https://doaj.org/article/bd1b76e9fe9141558b4ff19f139b0217
Autor:
Anna Gebhard, Patrick Lilienthal, Markus Metzler, Manfred Rauh, Sebastian Sager, Kjeld Schmiegelow, Linea Natalie Toksvang, Jakob Zierk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract In the treatment of childhood acute lymphoblastic leukemia (ALL), current protocols combine initial high-dose multiagent chemotherapy with prolonged oral therapy with 6-mercaptopurine (6MP) and low-dose methotrexate (MTX) maintenance therapy
Externí odkaz:
https://doaj.org/article/b86bec0f09924e3bb8156038dcf5f060
Autor:
Gina Hofmann, Jakob Zierk, Bettina Sobik, Zofia Wotschofsky, Stephanie Sembill, Manuela Krumbholz, Markus Metzler, Axel Karow
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The cellular reconstitution after childhood cancer therapy is associated with the risk of infection and efficacy of revaccination. Many studies have described the reconstitution after stem cell transplantation (SCT). The recovery after cance
Externí odkaz:
https://doaj.org/article/8caed9f9494b42b2a3e164b279b5c348
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Reference intervals represent the expected range of physiological test results in a healthy population and are essential to support medical decision making. Particularly in the context of pediatric reference intervals, where recru
Externí odkaz:
https://doaj.org/article/2cdc4cf433a841cfb161534ea2017f12
Autor:
Franz X. Mayr, Alexander Bertram, Holger Cario, Michael C. Frühwald, Hans-Jürgen Groß, Arndt Groening, Stefanie Grützner, Thomas Gscheidmeier, Reinhard Hoffmann, Alexander Krebs, Hans-Georg Ruf, Antje Torge, Joachim Woelfle, Oliver Razum, Manfred Rauh, Markus Metzler, Jakob Zierk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Reference intervals for laboratory test results have to be appropriate for the population in which they are used to be clinically useful. While sex and age are established partitioning criteria, patients’ origin also influences laboratory
Externí odkaz:
https://doaj.org/article/8baf5a74253541128ee6022c0edbc56c
Autor:
Tatjana Ammer, André Schützenmeister, Hans-Ulrich Prokosch, Manfred Rauh, Christopher M. Rank, Jakob Zierk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Reference intervals are essential for the interpretation of laboratory test results in medicine. We propose a novel indirect approach to estimate reference intervals from real-world data as an alternative to direct methods, which require sam
Externí odkaz:
https://doaj.org/article/e221b54fbd294da994f4057aa0be46c4
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Medical decision making based on quantitative test results depends on reliable reference intervals, which represent the range of physiological test results in a healthy population. Current methods for the estimation of reference l
Externí odkaz:
https://doaj.org/article/154e44f7de5b4e2a9fb9c4e96b723480
Autor:
Felix Jost, Jakob Zierk, Thuy T. T. Le, Thomas Raupach, Manfred Rauh, Meinolf Suttorp, Martin Stanulla, Markus Metzler, Sebastian Sager
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Acute lymphoblastic leukemia is the most common malignancy in childhood. Successful treatment requires initial high-intensity chemotherapy, followed by low-intensity oral maintenance therapy with oral 6-mercaptopurine (6MP) and methotrexate (MTX) unt
Externí odkaz:
https://doaj.org/article/b0a0ea801b3f41cb88cec2c78ae6b713
Autor:
Julian Gruendner, Thorsten Schwachhofer, Phillip Sippl, Nicolas Wolf, Marcel Erpenbeck, Christian Gulden, Lorenz A Kapsner, Jakob Zierk, Sebastian Mate, Michael Stürzl, Roland Croner, Hans-Ulrich Prokosch, Dennis Toddenroth
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225442 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0223010.].
Externí odkaz:
https://doaj.org/article/e28cf94954d64abfbeb474e09a131175
Autor:
Julian Gruendner, Thorsten Schwachhofer, Phillip Sippl, Nicolas Wolf, Marcel Erpenbeck, Christian Gulden, Lorenz A Kapsner, Jakob Zierk, Sebastian Mate, Michael Stürzl, Roland Croner, Hans-Ulrich Prokosch, Dennis Toddenroth
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223010 (2019)
BACKGROUND AND OBJECTIVE:To take full advantage of decision support, machine learning, and patient-level prediction models, it is important that models are not only created, but also deployed in a clinical setting. The KETOS platform demonstrated in
Externí odkaz:
https://doaj.org/article/8a7b137fcf1b4cb785d291f76afde964