Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jakob Von Engelhardt"'
Autor:
Susanne Erdinger, Irmgard Amrein, Michaela Back, Susann Ludewig, Martin Korte, Jakob von Engelhardt, David P. Wolfer, Ulrike C. Müller
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The amyloid precursor protein APP plays a crucial role in Alzheimer pathogenesis. Its physiological functions, however, are only beginning to be unraveled. APP belongs to a small gene family, including besides APP the closely related amyloid precurso
Externí odkaz:
https://doaj.org/article/ffbf24cb46bb4306b854fd2685dece4f
Autor:
Muhammad Aslam, Nirosiya Kandasamy, Anwar Ullah, Nagarajan Paramasivam, Mehmet Ali Öztürk, Saima Naureen, Abida Arshad, Mazhar Badshah, Kafaitullah Khan, Muhammad Wajid, Rashda Abbasi, Muhammad Ilyas, Roland Eils, Matthias Schlesner, Rebecca C. Wade, Nafees Ahmad, Jakob von Engelhardt
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Rare variants in the beta-glucocerebrosidase gene (GBA1) are common genetic risk factors for alpha synucleinopathy, which often manifests clinically as GBA-associated Parkinson’s disease (GBA-PD). Clinically, GBA-PD closely mimics idiopath
Externí odkaz:
https://doaj.org/article/00fdca4b28364121a50045369d0c8c8f
Autor:
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, pred
Externí odkaz:
https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6
Autor:
Florian Freudenberg, Esin Candemir, Xufeng Chen, Li-Li Li, Dilhan Esen-Sehir, Nicole Schenk, Makoto Kinoshita, Lena Grünewald, Veronika Frerichs, Nikolai Fattakhov, Jessica Manchen, Solmaz Bikas, Anita Kumar, Aet OLeary, David A. Slattery, Jakob von Engelhardt, Michael J. Courtney, Andreas Reif
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103565- (2021)
Background: Nitric oxide synthase 1 adaptor protein (NOS1AP; previously named CAPON) is linked to the glutamatergic postsynaptic density through interaction with neuronal nitric oxide synthase (nNOS). NOS1AP and its interaction with nNOS have been as
Externí odkaz:
https://doaj.org/article/38cf142210fc4beeb6a89b3aa32c23c7
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-20 (2018)
Abstract Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early events in Alzheimer’s disease (AD) pathogenesis. N-methyl-D-aspartate receptors (NMDARs) have previously been suggested to play a role for Amyloid be
Externí odkaz:
https://doaj.org/article/ca16cadee91547678309f047b42f3ecb
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The function of receptor desensitization in vivo is not well understood. Here, the authors show that deletion of CKAMP44, an AMPAR auxiliary protein that modulates desensitization of AMPAR currents, affects synaptic facilitation at retinogeniculate s
Externí odkaz:
https://doaj.org/article/993e2dfbe56d42b8b16b0d79d74bc768
Autor:
Anwarullah, Muhammad Aslam, Mazhar Badshah, Rashda Abbasi, Aneesa Sultan, Kafaitullah Khan, Nafees Ahmad, Jakob von Engelhardt
Publikováno v:
Genes and Environment, Vol 39, Iss 1, Pp 1-6 (2017)
Abstract Background Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson’s disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD beca
Externí odkaz:
https://doaj.org/article/b812eb69f5cb473484055e639b122715
Autor:
Si Chen, Nathalie Tisch, Marcel Kegel, Rosario Yerbes, Robert Hermann, Hannes Hudalla, Cecilia Zuliani, Gülce Sila Gülcüler, Klara Zwadlo, Jakob von Engelhardt, Carmen Ruiz de Almodóvar, Ana Martin-Villalba
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1378-1393 (2017)
The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions
Externí odkaz:
https://doaj.org/article/f4c6c6f6c1234f02b796243e1b5ae530
Autor:
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19869-5.
Externí odkaz:
https://doaj.org/article/c738b51898ee471abdbbcfbf08df9c18
Autor:
Paul Farrow, Konstantin Khodosevich, Yechiam Sapir, Anton Schulmann, Muhammad Aslam, Yael Stern-Bach, Hannah Monyer, Jakob von Engelhardt
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/c1538b0c596949e5be5c65bd49f92797