Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Jakob Troppmair"'
Autor:
Theresa Hautz, Hubert Hackl, Hendrik Gottschling, Raphael Gronauer, Julia Hofmann, Stefan Salcher, Bettina Zelger, Rupert Oberhuber, Benno Cardini, Annemarie Weissenbacher, Thomas Resch, Jakob Troppmair, Stefan Schneeberger
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105330- (2024)
Summary: Background: A better understanding of the molecular events during liver normothermic machine perfusion (NMP) is warranted to develop a data-based approach for the identification of biomarkers representative of graft quality and posttransplan
Externí odkaz:
https://doaj.org/article/dabf014d3eea4d158514cdf8c8d27c59
Autor:
Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan
Publikováno v:
eLife, Vol 13 (2024)
Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of suc
Externí odkaz:
https://doaj.org/article/71c92e4b1a0b490fa5cb3387e2ae8a9c
Autor:
Andras T. Meszaros, Annemarie Weissenbacher, Melanie Schartner, Tim Egelseer-Bruendl, Martin Hermann, Jasmin Unterweger, Christa Mittelberger, Beatrix A. Reyer, Julia Hofmann, Bettina G. Zelger, Theresa Hautz, Thomas Resch, Christian Margreiter, Manuel Maglione, Timea Komlódi, Hanno Ulmer, Benno Cardini, Jakob Troppmair, Dietmar Öfner, Erich Gnaiger, Stefan Schneeberger, Rupert Oberhuber
Publikováno v:
Transplant International, Vol 37 (2024)
Donor organ biomarkers with sufficient predictive value in liver transplantation (LT) are lacking. We herein evaluate liver viability and mitochondrial bioenergetics for their predictive capacity towards the outcome in LT. We enrolled 43 consecutive
Externí odkaz:
https://doaj.org/article/0fa1744622fe42b993bcf6d4d4930586
Autor:
Florian Primavesi, Thomas Senoner, Sophie Schindler, Aleksandar Nikolajevic, Pietro Di Fazio, Georg Csukovich, Silvia Eller, Bettina Neumayer, Markus Anliker, Eva Braunwarth, Rupert Oberhuber, Thomas Resch, Manuel Maglione, Benno Cardini, Thomas Niederwieser, Silvia Gasteiger, Eckhard Klieser, Herbert Tilg, Stefan Schneeberger, Daniel Neureiter, Dietmar Öfner, Jakob Troppmair, Stefan Stättner
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 590 (2024)
Post-hepatectomy liver failure (PHLF) remains the major contributor to death after liver resection. Oxidative stress is associated with postoperative complications, but its impact on liver function is unclear. This first in-human, prospective, single
Externí odkaz:
https://doaj.org/article/d5da90c36d384f1ea045b7c1f7d7b7c9
Autor:
Andras T. Meszaros, Julia Hofmann, Madita L. Buch, Benno Cardini, Theresia Dunzendorfer-Matt, Florian Nardin, Michael J. Blumer, Margot Fodor, Martin Hermann, Bettina Zelger, Giorgi Otarashvili, Melanie Schartner, Annemarie Weissenbacher, Rupert Oberhuber, Thomas Resch, Jakob Troppmair, Dietmar ..fner, Heinz Zoller, Herbert Tilg, Erich Gnaiger, Theresa Hautz, Stefan Schneeberger
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104311- (2022)
Summary: Background: Reliable biomarkers for organ quality assessment during normothermic machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by oxidative phosphorylation plays a crucial role in the bioenergetic homeostasis o
Externí odkaz:
https://doaj.org/article/e529ae879efe4ad79d300a1b0ac02665
Autor:
Franka Messner, Marco Thurner, Jule Müller, Michael Blumer, Julia Hofmann, Rainer Marksteiner, Sebastien Couillard-Despres, Jakob Troppmair, Dietmar Öfner, Stefan Schneeberger, Theresa Hautz
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Background Muscle is severely affected by ischemia/reperfusion injury (IRI). Quiescent satellite cells differentiating into myogenic progenitor cells (MPC) possess a remarkable regenerative potential. We herein established a model of local a
Externí odkaz:
https://doaj.org/article/74a4fedf37974a51a18b663d56e42066
Autor:
Marco Thurner, Martin Deutsch, Katrin Janke, Franka Messner, Christina Kreutzer, Stanislav Beyl, Sébastien Couillard-Després, Steffen Hering, Jakob Troppmair, Rainer Marksteiner
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract Background Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal muscle sphincters, s
Externí odkaz:
https://doaj.org/article/dcc1b4dfa47d4f77bf9bbcc837b7b261
Autor:
Foroogh Mirzania, Mahdi Moridi Farimani, Yaghoub Sarrafi, Samad Nejad Ebrahimi, Jakob Troppmair, Marcel Kwiatkowski, Hermann Stuppner, Mostafa Alilou
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. afforded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F (1–6), and one new nor-diterpenoid (7). Their structures were estab
Externí odkaz:
https://doaj.org/article/a6620a9a204841d49738c6f9199f0b9f
Novel, Innovative Models to Study Ischemia/Reperfusion-Related Redox Damage in Organ Transplantation
Autor:
Julia Hofmann, Marlene Pühringer, Sabrina Steinkellner, Aline-Sophie Holl, Andras T. Meszaros, Stefan Schneeberger, Jakob Troppmair, Theresa Hautz
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 31 (2022)
The implementation of ex vivo organ machine perfusion (MP) into clinical routine undoubtedly helped to increase the donor pool. It enables not just organ assessment, but potentially regeneration and treatment of marginal organs in the future. During
Externí odkaz:
https://doaj.org/article/79ac523de8e745a49113b840b2af5604
Publikováno v:
Molecular Oncology, Vol 12, Iss 6, Pp 869-882 (2018)
Metabolic reprogramming, as exemplified by the shift from oxidative phosphorylation to glycolysis, is a common feature of transformed cells. In many tumors, altered metabolism is also reflected in increased reactive oxygen species (ROS) levels, which
Externí odkaz:
https://doaj.org/article/1cead740927a4c9e9b5a4e9b1a241f7c