Persistent binding at dopamine transporters determines sustained psychostimulant effects

Autor: Marco Niello, Spyridon Sideromenos, Ralph Gradisch, Ronan O´Shea, Jakob Schwazer, Julian Maier, Nina Kastner, Walter Sandtner, Kathrin Jäntsch, Carl R. Lupica, Alexander F. Hoffman, Gert Lubec, Claus J. Loland, Thomas Stockner, Daniela D. Pollak, Michael H. Baumann, Harald H. Sitte

Publikováno v: Niello, M, Sideromenos, S, Gradisch, R, O'Shea, R, Schwazer, J, Maier, J, Kastner, N, Sandtner, W, Jäntsch, K, Lupica, C R, Hoffman, A F, Lubec, G, Loland, C J, Stockner, T, Pollak, D D, Baumann, M H & Sitte, H H 2023, ' Persistent binding at dopamine transporters determines sustained psychostimulant effects ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 6, e2114204120 . https://doi.org/10.1073/pnas.2114204120

Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for the treatment of specific neuropsychiatric disorders. However, they can also pro-duce severe and persistent adverse events. Often, their pharmacological pro

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https://doi.org/10.1073/pnas.2114204120