Single-photon microscopy to study biomolecular condensates

Autor: Eleonora Perego, Sabrina Zappone, Francesco Castagnetti, Davide Mariani, Erika Vitiello, Jakob Rupert, Elsa Zacco, Gian Gaetano Tartaglia, Irene Bozzoni, Eli Slenders, Giuseppe Vicidomini

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Biomolecular condensates serve as membrane-less compartments within cells, concentrating proteins and nucleic acids to facilitate precise spatial and temporal orchestration of various biological processes. The diversity of these processes an

Externí odkaz: https://doaj.org/article/7529e259296b4e6d894425d6ea688614

A Computational Approach Reveals the Ability of Amyloids to Sequester RNA: the Alpha Synuclein Case

Autor: Jakob Rupert, Michele Monti, Elsa Zacco, Gian Gaetano Tartaglia

Nucleic acids can act as potent modulators of protein aggregation, and RNA is able to either hinder or facilitate protein assembly depending on the molecular context. Here we used a computational approach to characterize the physico-chemical properti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c508ead7d97fa81a115dc0701de942c
https://doi.org/10.1101/2022.09.20.508776

Contributors

Autor: Murali Aarthy, Bidisha Acharya, Priyanka Aggarwal, Nabeel Ahmad, Natarajan Aiswarya, Hakan Alici, Khattab Al-Khafaji, Anshul Assaiya, Saurabh Bansal, Suparna Bhar, Aparna Bhardwaj, Dhiraj Bhatia, Neel Sarovar Bhavesh, Joanna Bons, Krishnananda Chattopadhyay, Purna Bahadur Chetri, Orkid Coskuner-Weber, Soumya De, Veronica Isabel Dodero, Jack A. Elias, Agusti Emperador, Roberto Giambruno, Marco Giampà, Rajanish Giri, Steffen P. Graether, Akshita Gupta, Smita Gupta, Md Anzarul Haque, Orkun Hasekioglu, Md Imtaiyaz Hassan, Prajna N. Hebbar, A. Hema Naveena, Maria Georgina Herrera, Alexander-Maurice Illig, Asimul Islam, Matej Janežič, Jeyaraman Jeyakanthan, Suchitra Kamle, Kota Kasahara, Punit Kaur, Heena Khan, Janesh Kumar, Prateek Kumar, Ritesh Kumar, Saravanan Kumar, Vijay Kumar, Pooja Kumari, Varsha Kumari, Bishwajit Kundu, Chun Geun Lee, Dawei Li, Xubo Lin, Snigdha Maiti, Narattam Mandal, Anil Mhashal, Parul Mishra, Ajitha Mohan, Sandip Mukherjee, Sunandan Mukherjee, Niharika Nag, Koomity V. Nageswar, Fouzia Nasim, Santoshi Nayak, Siddharth Neog, Chandran Nithin, Amy O’Broin, Olujide O. Olubiyi, Laura Orellana, Aditya K. Padhi, Amrita Arpita Padhy, Dipak N. Patil, Vijay Kumar Prajapati, Insaf Ahmed Qureshi, Chandrashekar Narayanan Rahul, Anjali Rajwar, Kristijan Ramadan, S. Rashmi, Tadi Sai Ratnakar, Arun Kumar Rawat, Jacob Rose, Anwesha Roy, Jakob Rupert, Subhashree Sahoo, Nikita V. Saibo, Suman Samantray, Nikhil H. Samarth, Madhumathi Sanjeevi, Achinta Sannigrahi, Santanu Sasidharan, Prakash Saudagar, Birgit Schilling, Kanagaraj Sekar, Mansi Sharma, Pradeep Sharma, Sujata Sharma, Vinita Sharma, Kummari Shivani, Abhay Narayan Singh, Anamika Singh, Appu K. Singh, Meenakshi Singh, Sanjeev Kumar Singh, Satyendra Singh, Shailza Singh, Shalini Singh, Sudhir Kumar Singh, Tej P. Singh, Tugba Taskin-Tok, Arianne L. Theiss, Nicolo Tonali, Timir Tripathi, Vishal Trivedi, Vladimir N. Uversky, Payal Vaswani, K. Venuprasad, Elsa Zacco, Kam Y.J. Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ebc2116dc18e4be848d6c848acde5d9
https://doi.org/10.1016/b978-0-323-90264-9.09988-8

New lessons on TDP-43 from the killifish N. furzeri

Autor: Sara Bagnoli, Alexandra Louka, Eva Terzibasi Tozzini, Annalisa Pastore, Alessandro Cellerino, Jakob Rupert, Esapa B, Gian Gaetano Tartaglia

Frontotemporal dementia and amyotrophic lateral sclerosis are fatal and incurable neurodegenerative diseases linked to the pathological aggregation of the TDP-43 protein. This is an essential DNA/RNA binding protein involved in transcription regulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c193a2695670a31e1c6e9ec0ecbafe0
https://doi.org/10.1101/2021.02.04.429704

Structural analysis of SARS-CoV-2 and predictions of the human interactome

Autor: Jakob Rupert, Michele Monti, Gian Gaetano Tartaglia, Andrea Vandelli, Elsa Zacco, Alexandros Armaos, Riccardo Delli Ponti, Elias Bechara, Edoardo Milanetti

Publikováno v: Nucleic Acids Research
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
bioRxiv

Specific elements of viral genomes regulate interactions within host cells. Here, we calculated the secondary structure content of >2000 coronaviruses and computed >100 000 human protein interactions with severe acute respiratory syndrome coronavirus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1f87bd25d69bbfc9a326799989a243