Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jakob Regberg"'
Publikováno v:
Pharmaceuticals, Vol 5, Iss 9, Pp 991-1007 (2012)
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor c
Externí odkaz:
https://doaj.org/article/46b9a1e646a84fe7b753d90cb9325441
Publikováno v:
International Journal of Pharmaceutics. 500:128-135
Receptor-mediated transcytosis remains a major route for drug delivery across the blood-brain barrier (BBB). PepFect 32 (PF32), a peptide-based vector modified with targeting ligand (Angiopep-2) binding to low-density lipoprotein receptor-related pro
Autor:
Shereen Ezzat, Anil K. Rustgi, Stuart L. Schreiber, Kay Washington, Arul M. Chinnaiyan, Andrew L. Kung, Elena V. Komissarova, Charles Karan, Beatrice S. Knudsen, Diane Reidy-Lagunes, Daniel Diolaiti, Zhong Li, Irvin M. Modlin, Roberto Bergamaschi, Andrea Frilling, Jakob Regberg, David C. Metz, Filemon S. Dela Cruz, Deepti Dhall, Douglas A. Fraker, Emer Leahy, Ülo Langel, Ronald Realubit, Laura H. Tang, Stefano Serra, Afshin Ghavami, Prem S. Subramaniam, Antonia R. Sepulveda, Tony Detre, Lisa Bodei, Jeffrey W. Milsom, Xiaopu Yuan, Mark Kidd, Andrea Califano, Daniel Kaemmerer, Kyoung Mi Kim, Young Suk Park, Mariano J. Alvarez, Paul A. Clemons, Elizabeth A. Hagan, Robert E. Roses, Helen Remotti, Jeeyun Lee, Hai Li, Roswitha Pfragner, Massimo Barberis, Merten Hommann, Virginia A. LiVolsi, Allison R. Rainey, Michelle K. Kim, Adina Grunn, Gabrielle E. Rieckhof, Chanjuan Shi, Bertram Wiedenmann, Hee C. Kim, Dirk Jaeger, Lakshmi P. Kunju, Mahalaxmi Aburi
Publikováno v:
Nat Genet
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis of their ability to invert the concerted a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d09dc99068d6a36407f03e9aa66176
http://hdl.handle.net/10044/1/60492
http://hdl.handle.net/10044/1/60492
Autor:
Mattias Hällbrink, Ülo Langel, Mati Karelson, Dimitar A. Dobchev, Jakob Regberg, Moataz Dowaidar, Tõnis Lehto
Cell-penetrating peptide (CPP) based transfection systems (PBTS) are a promising class of drug delivery vectors. CPPs are short mainly cationic peptides capable of delivering cell non-permeant cargo to the interior of the cell. Some CPPs have the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fd0dbdece75872eb33554086deaf1c
http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-140132
http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-140132
Autor:
Mattias Hällbrink, Kaido Kurrikoff, Kadi-Liis Veiman, Artita Srimanee, Jakob Regberg, Opa Vajragupta, Ülo Langel
Publikováno v:
International Journal of Peptide Research and Therapeutics. 20:169-178
Delivery of pharmaceutical agents across a blood–brain barrier (BBB) is a challenge for brain cancer therapy. In this study, an in vitro BBB model was utilized to study the delivery of oligonucleotides across brain endothelial cells targeting to gl
Publikováno v:
Scopus-Elsevier
The field of gene therapy is starting to move towards clinical applications but is currently limited by the lack of efficient delivery systems. Cell-penetrating peptides provide a means of cellular delivery for gene therapy applications as well as de
Publikováno v:
Future Microbiology. 7:519-533
In complex environments, such as those found in the human host, pathogenic bacteria constantly battle the unfavorable conditions imposed by the host response to their presence. During Escherichia coli-induced pyelonephritis, a cascade of events are s
Publikováno v:
International journal of pharmaceutics. 501(1-2)
A series of cell-penetrating PepFect peptide analogues was developed by substitutions of the galanin-derived N-terminal sequence. Histidine modifications were incorporated in order to make the peptides pH-responsive. The peptides were all able to for
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1324
Cell-penetrating peptides provide a promising strategy for delivery of drugs across the blood-brain barrier. Here, we present an overview of CPP and peptide-mediated delivery to the central nervous system as well as a Transwell in vitro model to eval
Publikováno v:
Methods in Molecular Biology ISBN: 9781493928057
Cell-penetrating peptides provide a promising strategy for delivery of drugs across the blood-brain barrier. Here, we present an overview of CPP and peptide-mediated delivery to the central nervous system as well as a Transwell in vitro model to eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625bd3140797383ffa4fa14fffa9b0d3
https://doi.org/10.1007/978-1-4939-2806-4_23
https://doi.org/10.1007/978-1-4939-2806-4_23