Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Jakob Lewin Rukov"'
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Akademický článek
Evolution of alternative splicing regulation: changes in predicted exonic splicing regulators are not associated with changes in alternative splicing levels in primates.
Autor: Manuel Irimia, Jakob Lewin Rukov, Scott William Roy
Publikováno v: PLoS ONE, Vol 4, Iss 6, p e5800 (2009)
Alternative splicing is tightly regulated in a spatio-temporal and quantitative manner. This regulation is achieved by a complex interplay between spliceosomal (trans) factors that bind to different sequence (cis) elements. cis-elements reside in bot
Externí odkaz: https://doaj.org/article/d2b44af68dc5483b98580ec8e757466a
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2
Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat
Autor: Vera Gorbunova, J. Strand, Jakob Lewin Rukov, Ewa Lewin, Maria L. Mace, Klaus Olgaard, C. Doganli, Søren Egstrand, Anders Nordholm, S. B. Torsetnes, Marya Morevati
Publikováno v: Morevati, M, Mace, M L, Egstrand, S, Nordholm, A, Doganli, C, Strand, J, Rukov, J L, Torsetnes, S B, Gorbunova, V, Olgaard, K & Lewin, E 2021, ' Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat ', Scientific Reports, vol. 11, 15375 . https://doi.org/10.1038/s41598-021-94972-1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats. α-Klotho (klotho) is an aging-sup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deca2e2cecdd22e19b3fc5c3a513b95e
https://curis.ku.dk/ws/files/276270912/s41598_021_94972_1.pdf
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3
A molecular circadian clock operates in the parathyroid gland and is disturbed in chronic kidney disease associated bone and mineral disorder
Autor: Tally Naveh-Many, Maria L. Mace, Anders Nordholm, Klaus Olgaard, Alia Hassan, Marya Morevati, Jakob Lewin Rukov, Ewa Lewin, Eva Gravesen, Søren Egstrand
Publikováno v: Egstrand, S, Nordholm, A, Morevati, M, Mace, M L, Hassan, A, Naveh-many, T, Rukov, J L, Gravesen, E, Olgaard, K & Lewin, E 2020, ' A molecular circadian clock operates in the parathyroid gland and is disturbed in chronic kidney disease associated bone and mineral disorder ', Kidney International, vol. 98, no. 6, pp. 1461-1475 . https://doi.org/10.1016/j.kint.2020.06.034
Circadian rhythms in metabolism, hormone secretion, cell cycle and locomotor activity are regulated by a molecular circadian clock with the master clock in the suprachiasmatic nucleus of the central nervous system. However, an internal clock is also
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b848a8dc6c4dd5a2f098867b7191c887
https://curis.ku.dk/portal/da/publications/a-molecular-circadian-clock-operates-in-the-parathyroid-gland-and-is-disturbed-in-chronic-kidney-disease-associated-bone-and-mineral-disorder(d15d0df6-fc1e-4847-bdc8-fa3bb5345048).html
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4
Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs
Autor: Yanping Feng, Jeppe Vinther, Jakob Lewin Rukov, Peter Hagedorn, Isabel Bro Høy, Morten Lindow
Publikováno v: Rukov, J L, Hagedorn, P H, Høy, I B, Feng, Y, Lindow, M & Vinther, J 2015, ' Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs ', Nucleic Acids Research, vol. 43, no. 17, pp. 8476-8487 . https://doi.org/10.1093/nar/gkv759
Nucleic Acids Research
Processing and post-transcriptional regulation of RNA often depend on binding of regulatory molecules to short motifs in RNA. The effects of such interactions are difficult to study, because most regulatory molecules recognize partially degenerate RN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a931fe5cd96bc61936b9ba1cb620285d
https://doi.org/10.1093/nar/gkv759
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5
Pharmaco-miR: linking microRNAs and drug effects
Autor: Noam Shomron, Jakob Lewin Rukov, Jeppe Vinther, Roni Wilentzik, Ishai Jaffe
Publikováno v: Rukov, J L, Wilentzik, R, Jaffe, I, Vinther, J & Shomron, N 2014, ' Pharmaco-miR : linking microRNAs and drug effects ', Briefings in Bioinformatics, vol. 15, no. 4, pp. 648-659 . https://doi.org/10.1093/bib/bbs082
Briefings in Bioinformatics
MicroRNAs (miRNAs) are short regulatory RNAs that down-regulate gene expression. They are essential for cell homeostasis and active in many disease states. A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6011b8d04ecb2a56da67f654f9b216e
https://doi.org/10.1093/bib/bbs082
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7
Widespread Evolutionary Conservation of Alternatively Spliced Exons in Caenorhabditis
Autor: Scott William Roy, Jordi Garcia-Fernàndez, Jeppe Vinther, David Penny, Manuel Irimia, Jakob Lewin Rukov
Publikováno v: Molecular Biology and Evolution. 25:375-382
Alternative splicing (AS) contributes to increased transcriptome and proteome diversity in various eukaryotic lineages. Previous studies showed low levels of conservation of alternatively spliced (cassette) exons within mammals and within dipterans.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bea27341d76741ef3c924b38c09bb1
https://doi.org/10.1093/molbev/msm262
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8
Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing
Autor: Claus B. Andersen, Jacob Hofman-Bang, Jeppe Vinther, Klaus Olgaard, Ewa Lewin, Eva Gravesen, Maria L. Mace, Jakob Lewin Rukov
Publikováno v: American journal of physiology. Renal physiology. 310(6)
The development of vascular calcification (VC) in chronic uremia (CU) is a tightly regulated process controlled by factors promoting and inhibiting mineralization. Next-generation high-throughput RNA sequencing (RNA-seq) is a powerful and sensitive t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025cc8f91c0109abc3741189de707d88
https://pubmed.ncbi.nlm.nih.gov/26739890
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10
Pharmacogenomics genes show varying perceptibility to microRNA regulation
Autor: Noam Shomron, Jakob Lewin Rukov, Jeppe Vinther
Publikováno v: Pharmacogenetics and genomics. 21(5)
Objective The aim of pharmacogenomics is to identify individual differences in genome and transcriptome composition and their effect on drug efficacy. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate expression of the majority of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b83b248ae51de556c2fc7fe2adc9c82
https://pubmed.ncbi.nlm.nih.gov/21499217
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