Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jakob Leppkes"'
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 400-402 (2021)
Externí odkaz:
https://doaj.org/article/545da758be944123b4f9405e0beae59b
Autor:
Jakob Leppkes, Nicole Dimos, Bernhard Loll, Thomas Hohmann, Michael Dyrks, Ariane Wieseke, Bettina G. Keller, Beate Koksch
Substituting the P1 position in bovine pancreatic trypsin inhibitor (BPTI) is known to heavily influence its inhibitory activity towards serine proteases. Side-chain fluorinated aliphatic amino acids have been shown to alter numerous properties of pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad3d390f5ae5235ee0fd455ed59f21
https://doi.org/10.26434/chemrxiv-2022-qq9nr-v2
https://doi.org/10.26434/chemrxiv-2022-qq9nr-v2
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 400-402 (2021)
ACS Central Science
ACS Central Science
An N-alkylation strategy to impart protease resistance to therapeutic peptides for type 2 diabetes management also proves nonperturbative to agonist potency.
Autor:
Susanne Huhmann, Johann Moschner, Beate Koksch, Rita Fernandes, Jakob Leppkes, Valentina Stulberg
Publikováno v:
Chemical Reviews. 119:10718-10801
Fluorine does not belong to the pool of chemical elements that nature uses to build organic matter. However, chemists have exploited the unique properties of fluorine and produced countless fluoro-organic compounds without which our everyday lives wo
Publikováno v:
Chemistry - An Asian Journal. 11:3062-3071
Several functionalized and non-functionalized perfluoroarenes were catalytically transformed into their para-hydrodefluorinated products by using catalytic amounts of titanocene difluoride and stoichiometric amounts diphenylsilane. Turnover numbers o
Publikováno v:
Journal of Fluorine Chemistry. 232:109453
Fluorine, as a substituent in amino acids, has found its way into peptide and protein engineering. The basis for the use of this valuable tool is the synthetic accessibility of various fluorinated amino acids as building blocks of peptides and protei