Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jakob J Metzger"'
Autor:
Anna Yoney, Fred Etoc, Albert Ruzo, Thomas Carroll, Jakob J Metzger, Iain Martyn, Shu Li, Christoph Kirst, Eric D Siggia, Ali H Brivanlou
Publikováno v:
eLife, Vol 7 (2018)
Self-organization of discrete fates in human gastruloids is mediated by a hierarchy of signaling pathways. How these pathways are integrated in time, and whether cells maintain a memory of their signaling history remains obscure. Here, we dissect the
Externí odkaz:
https://doaj.org/article/f63cd96773234a5c94c1350230c6fbcc
Autor:
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A. M. Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C. Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E. Wanker, Josef Priller, Jakob J. Metzger, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic in
Externí odkaz:
https://doaj.org/article/340c015abcae4c679391b04ea77b6a41
Autor:
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis
Publikováno v:
eLife, Vol 7 (2018)
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces.
Externí odkaz:
https://doaj.org/article/8eea50c5e0f14b07bca739e2f1420f10
Autor:
Jakob J Metzger, Stephan Eule
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 11, p e1003303 (2013)
Muller's ratchet is a paradigmatic model for the accumulation of deleterious mutations in a population of finite size. A click of the ratchet occurs when all individuals with the least number of deleterious mutations are lost irreversibly due to a st
Externí odkaz:
https://doaj.org/article/53cc4e6e15934c7a915c2ad45ad112bd
Autor:
Stephan Eule, Jakob J Metzger
Publikováno v:
New Journal of Physics, Vol 18, Iss 3, p 033006 (2016)
Stochastic processes that are randomly reset to an initial condition serve as a showcase to investigate non-equilibrium steady states. However, all existing results have been restricted to the special case of memoryless resetting protocols. Here, we
Externí odkaz:
https://doaj.org/article/5c0709b380d84c688a4e1b9183a06fb3
Autor:
Jakob J. Metzger, Carlota Pereda, Arjun Adhikari, Tomomi Haremaki, Szilvia Galgoczi, Eric D. Siggia, Ali H. Brivanlou, Fred Etoc
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100297- (2022)
Summary: Organoids are carrying the promise of modeling complex disease phenotypes and serving as a powerful basis for unbiased drug screens, potentially offering a more efficient drug-discovery route. However, unsolved technical bottlenecks of repro
Externí odkaz:
https://doaj.org/article/f5db8f46d9f243f3a2072ea7ecf2fe31
Autor:
Ali H Brivanlou, Jakob J. Metzger, David F Albertini, Tiago Rito, Rohan Soman, Jeffrey Naftaly, David H. Barad, Norbert Gleicher, Jianjun Hu, Min Yang
Publikováno v:
Nature Cell Biology. 23:314-321
Chromosomal instability leading to aneuploidy is pervasive in early human embryos1-3 and is considered as a major cause of infertility and pregnancy wastage4,5. Here we provide several lines of evidence that blastocysts containing aneuploid cells are
Autor:
Jakob J. Metzger, Christian Markopoulos, Szilvia Galgoczi, Ali H. Brivanlou, Anna Yoney, Fred Etoc, Tomomi Haremaki, Albert Ruzo, Tien Phan-Everson, Shu Li
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the huntingtin gene (HTT). Although HD has been shown to have a developmental component, how early during human embryogenesis the HTT-CAG exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e099c419db7405ce2203773fde32a74a
http://edoc.mdc-berlin.de/20973/1/20973oa.pdf
http://edoc.mdc-berlin.de/20973/1/20973oa.pdf
Publikováno v:
Nature Biotechnology. 37:1198-1208
Harnessing the potential of human embryonic stem cells to mimic normal and aberrant development with standardized models is a pressing challenge. Here we use micropattern technology to recapitulate early human neurulation in large numbers of nearly i
Autor:
Mijo Simunovic, Fred Etoc, Albert Ruzo, Iain Martyn, Anna Yoney, Gist F. Croft, Ali H Brivanlou, Jakob J. Metzger, Dong Shin You, Eric D. Siggia
Publikováno v:
Nature Cell Biology. 21:900-910
Breaking the anterior-posterior symmetry in mammals occurs at gastrulation. Much of the signalling network underlying this process has been elucidated in the mouse; however, there is no direct molecular evidence of events driving axis formation in hu