Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

Autor: Jakob J. Gutzmann, Lin Lin, Dax A. Hoffman

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 h

Externí odkaz: https://doaj.org/article/dded100dd42e4d6cbed372ba3ad0405c

R-type voltage-gated Ca

Autor: Jonathan G, Murphy, Jakob J, Gutzmann, Lin, Lin, Jiahua, Hu, Ronald S, Petralia, Ya-Xian, Wang, Dax A, Hoffman

Publikováno v: Cell reports. 38(3)

The subthreshold voltage-gated transient K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d12e789ab4b6abbdc44ee27d1719bcdf
https://pubmed.ncbi.nlm.nih.gov/35045307

Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility

Autor: Jia-Hua Hu, Stewart R. Durell, Ying Liu, Rose-Marie Karlsson, Heather A. Cameron, Jakob J. Gutzmann, G. Travis Tabor, Daniel Abebe, Cole Malloy, Dax A. Hoffman

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications

Voltage-gated K+ channels function in macromolecular complexes with accessory subunits to regulate brain function. Here, we describe a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)-dependent mechanism that regulates the association of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86de4b982ecf265c4dd0b5fcf1254e0
https://doi.org/10.1038/s41467-020-15390-x

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

Autor: Lin Lin, Dax A. Hoffman, Jakob J. Gutzmann

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)
Frontiers in Cellular Neuroscience

Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d3577350ed2abb13baac2ab876d8ee
https://www.frontiersin.org/article/10.3389/fncel.2019.00027/full

Different Motifs Regulate Trafficking of SorCS1 Isoforms

Autor: Morten Nielsen, Irm Hermans-Borgmeyer, Claus Munck Petersen, Camilla Gustafsen, Peder Madsen, Arne Engelsberg, Jørgen Gliemann, Guido Hermey, Jakob J. Gutzmann, Anders Nykjaer, Karen M. Pedersen, Jida W. Hamati, Dietmar Kuhl, Sady J. Keat

Publikováno v: Nielsen, M S, Keat, S J, Hamati, J W, Madsen, P, Gutzmann, J J, Engelsberg, A, Pedersen, K-M, Gustafsen, C, Nykjaer, A, Gliemann, J, Hermans-Borgmeyer, I, Kuhl, D, Petersen, C M & Hermey, G 2008, ' Different motifs regulate trafficking of SorCS1 isoforms ', Traffic, vol. 9, no. 6, pp. 980-94 . https://doi.org/10.1111/j.1600-0854.2008.00731.x

The type I transmembrane protein SorCS1 is a member of the Vps10p-domain receptor family comprised of Sortilin, SorLA and SorCS1, -2 and -3. Current information indicates that Sortilin and SorLA mediate intracellular protein trafficking and sorting,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d45e3a965984f99fbc4525f43ef00d9
https://doi.org/10.1111/j.1600-0854.2008.00731.x