Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Jakob Heid"'
1
Redistribution of GABAB(1)Protein and Atypical GABABResponses in GABAB(2)-Deficient Mice
Autor: Johannes Mosbacher, Matthias Müller, Yann Humeau, John F. Cryan, Andreas Lüthi, Klaus Klebs, Jakob Heid, Markus Schmutz, Bernd Kinzel, Martin Gassmann, Corinne Haller, Réjan Vigot, Anne Lise Jaton, Jean-Marc Fritschy, Klemens Kaupmann, Herman van der Putten, Lucas Lecourtier, Peter H. Kelly, Clive Gentry, Gilles Sansig, Hamdy Shaban, Wolfgang Froestl, Cedric Mombereau, Valerie Schuler, Bernhard Bettler, Samuel Barbieri
Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2004, 24 (5), pp.6086-6097. ⟨10.1523/jneurosci.5635-03.2004⟩
GABABreceptors mediate slow synaptic inhibition in the nervous system. In transfected cells, functional GABABreceptors are usually only observed after coexpression of GABAB(1)and GABAB(2)subunits, which established the concept of heteromerization for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efea78ecdd5312293b08c33d39110f30
https://doi.org/10.1523/jneurosci.5635-03.2004
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2
Ligands for expression cloning and isolation of GABAB receptors
Autor: Klemens Kaupmann, Helmut Bittiger, Jakob Heid, Wolfgang Fröstl, Dietrich Strub, Bernhard Bettler, Stuart J. Mickel
Publikováno v: Il Farmaco. 58:173-183
Outlined is the rationale behind the syntheses of radioligands [125I]CGP64213 and [125I]CGP71872, which led to the identification of cloned GABA(B) receptors 1a and 1b 17 years after the first pharmacological characterisation of native GABA(B) recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e22624feb8d9ee64717d91948403c28
https://doi.org/10.1016/s0014-827x(03)00018-1
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3
Positive Allosteric Modulation of Native and Recombinant γ-Aminobutyric AcidB Receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its Aldehyde Analog CGP13501
Autor: Johannes Mosbacher, Klemens Kaupmann, Stephan Urwyler, Jakob Heid, Bernhard Bettler, Karin Hofstetter, Kurt Lingenhoehl, Wolfgang Froestl
Publikováno v: Molecular Pharmacology. 60:963-971
The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of gamma-aminobutyric acid(B) (GABA(B)) receptor function. They potentiate GABA-stimulated guanosi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::732df28dba87c9a76e79e0ce7dc5b326
https://doi.org/10.1124/mol.60.5.963
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5
Ca2+ Requirement for High-Affinity γ-Aminobutyric Acid (GABA) Binding at GABAB Receptors: Involvement of Serine 269 of the GABABR1 Subunit
Autor: Barbara Malitschek, Jakob Heid, Cécile Joly, Klemens Kaupmann, Stephan Urwyler, Johannes Mosbacher, Jean-Philippe Pin, Wolfgang Froestl, Thierry Galvez, Laurent Prézeau, Bernhard Bettler, Isabelle Brabet
Publikováno v: Molecular Pharmacology. 57:419-426
The gamma-aminobutyric acid (GABA) receptor type B (GABA(B)R) is constituted of at least two homologous proteins, GABA(B)R1 and GABA(B)R2. These proteins share sequence and structural similarity with metabotropic glutamate and Ca(2+)-sensing receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b964f6bf23efaa9159b77de675b5c3
https://doi.org/10.1124/mol.57.3.419
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6
Ligands for the isolation of GABAB receptors W. Froestl would like to dedicate this work to the first GABAB chemist, Cr Heinrich Keberle, on the occasion of his 77th birthday
Autor: Stuart J. Mickel, Jakob Heid, Dietrich Strub, Klemens Kaupmann, Wolfgang Froestl, Bernhard Bettler, Helmut Bittiger
Publikováno v: Neuropharmacology. 38:1641-1646
Since the discovery that the most abundant inhibitory neurotransmitter in the mammalian brain, GABA (gamma-aminobutyric acid), interacts not only with ionotropic GABA(A) receptors, but also with metabotropic GABA(B) receptors (Bowery et al., 1980) mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c35423268583fd4d526461138a060d62
https://doi.org/10.1016/s0028-3908(99)00134-3
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7
GABAB-receptor subtypes assemble into functional heteromeric complexes
Autor: Jakob Heid, Pascal Beck, Andreas Karschin, Barbara Malitschek, Bernhard Bettler, Serge Bischoff, Wolfgang Froestl, Ákos Kulik, Ryuichi Shigemoto, Klemens Kaupmann, Johannes Mosbacher, Valerie Schuler
Publikováno v: Nature. 396:683-687
B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G-protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cycla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c971e66c9ae40c344db21a99877eed
https://doi.org/10.1038/25360
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8
Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors
Autor: Peter J. Flor, Christof Angst, Stuart J. Mickel, Katharina Huggel, Serge Bischoff, Mcmaster Gary Kent, Bernhard Bettler, Klemens Kaupmann, Jakob Heid, Helmut Bittiger, Wolfgang Froestl
Publikováno v: Nature. 386:239-246
GABA (gamma-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABA(A)/ GABA(c)) and metabotropic (GABA(B)) receptor systems. Here we report the cloning of GABA(B) receptors. Photoaffinity labelli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f661ec89d5fcd2925e7b92d0b25e557
https://doi.org/10.1038/386239a0
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