Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jakob Franke"'
Publikováno v:
Engineering in Life Sciences, Vol 22, Iss 12, Pp 803-810 (2022)
Abstract The Australian tobacco plant Nicotiana benthamiana is becoming increasingly popular as a platform for protein production and metabolic engineering. In this system, gene expression is achieved transiently by infiltrating N. benthamiana plants
Externí odkaz:
https://doaj.org/article/dab5db44017c42f0821fa011deecfba9
Autor:
Karan Malhotra, Jakob Franke
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1289-1310 (2022)
The cytochrome P450 monooxygenase (CYP) superfamily comprises hemethiolate enzymes that perform remarkable regio- and stereospecific oxidative chemistry. As such, CYPs are key agents for the structural and functional tailoring of triterpenoids, one o
Externí odkaz:
https://doaj.org/article/7158a8af9b9e4bb3b9003d8bc51c70a4
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
The tree of heaven, Ailanthus altissima (MILL.) SWINGLE, is a globally invasive plant known to secrete allelopathic metabolites called quassinoids. Quassinoids are highly modified triterpenoids. So far, nothing has been known about the biochemical ba
Externí odkaz:
https://doaj.org/article/3ffca957498e4e748fa58dbe87bc7dc6
Autor:
Sara Leite Dias, Adriana Garibay-Hernández, Fabian Leon Brendel, Benjamin Gabriel Chavez, Elena Brückner, Hans-Peter Mock, Jakob Franke, John Charles D’Auria
Publikováno v:
Plants, Vol 12, Iss 10, p 1930 (2023)
Barley (Hordeum vulgare) is one of the most widely cultivated crops for feedstock and beer production, whereas lupins (Lupinus spp.) are grown as fodder and their seeds are a source of protein. Both species produce the allelopathic alkaloids gramine
Externí odkaz:
https://doaj.org/article/c73b66fe305a47418637b2c2e186a4c4
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/e1b9c554e08b4e0d96d100f109fc60de
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2003-2012 (2019)
Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity. Her
Externí odkaz:
https://doaj.org/article/79b300b5654c43bc9a7ff932d28abbd9
Autor:
Evangelos C. Tatsis, Inês Carqueijeiro, Thomas Dugé de Bernonville, Jakob Franke, Thu-Thuy T. Dang, Audrey Oudin, Arnaud Lanoue, Florent Lafontaine, Anna K. Stavrinides, Marc Clastre, Vincent Courdavault, Sarah E. O’Connor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert
Externí odkaz:
https://doaj.org/article/03bb68418f55480082f388e21cdaf80b
Autor:
Ricarda Freke, Björn Heinemann, Samuel Edward Hakim, Claus‐Peter Witte, Marco Herde, Tatjana M. Hildebrandt, Jakob Franke
Publikováno v:
ChemBioChem. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbab6d221320c44e1d0ab420151773e9
https://doi.org/10.1002/cbic.202300056
https://doi.org/10.1002/cbic.202300056
Publikováno v:
Current opinion in plant biology. 71
Major hurdles in plant biosynthetic pathway elucidation and engineering include the need for rapid testing of enzyme candidates and the lack of complex substrates that are often not accumulated in the plant, amenable to synthesis, or commercially ava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633015157a4c78e790e968e8efacc4b9
https://pubmed.ncbi.nlm.nih.gov/36599248
https://pubmed.ncbi.nlm.nih.gov/36599248
Triterpenoids possess potent biological activities, but their polycyclic skeletons are challenging to synthesise. In biochemistry, the skeletal diversity of plant triterpenoids is normally generated by oxidosqualene cyclases and remains unaltered dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c53f322bf28dcbabd1411844fcf68d
https://doi.org/10.1101/2022.09.23.508984
https://doi.org/10.1101/2022.09.23.508984
