Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jakob Busch"'
Autor:
Adrian Constantin Tanjala, Jia Xin Jiang, Paul D. W. Eckford, Mohabir Ramjeesingh, Canhui Li, Ling Jun Huan, Gabrielle Langeveld, Claire Townsend, Daniel V. Paone, Jakob Busch-Petersen, Roman Pekhletski, LiPing Tang, Vamsee Raju, Steven M. Rowe, Christine E. Bear
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Cystic Fibrosis causing mutations in the gene CFTR, reduce the activity of the CFTR channel protein, and leads to mucus aggregation, airway obstruction and poor lung function. A role for CFTR in the pathogenesis of other muco-obst
Externí odkaz:
https://doaj.org/article/2da00d71ae6d4c6493740fb315b80270
Autor:
Robert Linke-Wittich, Christoph Schäper, Wulf-Holger Arndt, Jakob Busch, Elmer Van der Wel, Sarah Stelter
Publikováno v:
Journal für Mobilität und Verkehr. :14-26
Das Forschungsprojekt „Shuttles&Co" untersuchte im Zeitraum von Anfang 2020 bis Mitte 2022 den Realbetrieb von hochautomatisierten Shuttlebussen im öffentlichen Verkehr im Berliner Bezirk Alt-Tegel. Hierbei wurde ein Theoriemodell für Einstellung
Autor:
Xichen Lin, Michael E. Muratore, Huijie Li, Ami S. Lakdawala, Jakob Busch-Petersen, Ruth R. Osborn, David D. Miller, Jeffrey K. Kerns, Rick P. C. Cousins, Ian Robert Baldwin, Paul Bamborough, John Yonchuk, Ann M. Bullion, Lin Guoliang, Jeffrey C. Boehm, Wei Fu, John A. Christopher, Edward F. Webb, Roderick S. Davis, William L. Rumsey, Rita Field, Jeremy John Payne, Hong Nie
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1164-1169
[Image: see text] IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for
Autor:
Ruth J. Mayer, Michael Salmon, Miriam Burman, Donald C. Carpenter, Jakob Busch-Petersen, John Yonchuk, David J. Kilian, James J. Foley, Gerald E. Hunsberger, Ruth Tal-Singer
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(2)
CXC chemokine receptor 2 (CXCR2) is a key receptor in the chemotaxis of neutrophils to sites of inflammation. The studies reported here describe the pharmacological characterization of danirixin, a CXCR2 antagonist in the diaryl urea chemical class.
Autor:
Peter T. Buckley, James J. Foley, Edward F. Webb, Roderick S. Davis, Dulcie B. Schmidt, Jakob Busch-Petersen, Michael Salmon, Jian Jin, Widdowson Katherine L, Kristen E. Belmonte, Henry M. Sarau, Yonghui Wang, Qi Jin, Palovich Michael R, Ann M. Bullion
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7087-7091
Tyrosine ureas had been identified as potent muscarinic receptor antagonists with promising in vivo activity. Controlling the stereochemistry of the chiral quaternary ammonium center had proved to be a serious issue for this series, however. Herein w
Autor:
Henry M. Sarau, Sandra Umbrecht, Widdowson Katherine L, Palovich Michael R, Michael Salmon, Haibo Xie, Hongxing Yan, Jakob Busch-Petersen, Mark A. Luttmann, James J. Foley, Brian Peck, Jeremy Dufour, Zehong Wan, Gerald E. Hunsberger, Philip S. Landis, Dramane I. Laine, Alicia M. Bacon, Miriam Burman, Edward F. Webb, Roderick S. Davis, Dulcie B. Schmidt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3366-3369
A novel series of N-substituted tropane derivatives was characterized as potent muscarinic acetylcholine receptor antagonists (mAChRs). Kinetic washout studies showed that the N-endosubstituted analog 24 displayed much slower reversibility at mAChRs
Publikováno v:
Future Medicinal Chemistry. 3:1623-1634
In 2002, the first long-acting muscarinic antagonist, tiotropium bromide (Spiriva®), was launched as a once-daily bronchodilating agent for the treatment of chronic obstructive pulmonary disease. Since then, there has been intense discovery research
Autor:
Henry M. Sarau, Feng Wang, Gerald E. Hunsberger, Elizabeth A. Capper-Spudich, Ralph A. Rivero, James J. Foley, Yonghui Wang, Zheng Yang, Laura S. Fisher, Todd L. Graybill, Michael S. McQueney, Jian Jin, Widdowson Katherine L, Zining Wu, Dulcie B. Schmidt, Terence J. Kiesow, Jakob Busch-Petersen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:114-118
A series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 anta
Autor:
Jakob Busch-Petersen, Christine Edwards, Xichen Lin, Deng Jianghe, Zhaoguo Zhang, Jeffrey K. Kerns
Publikováno v:
Synlett. 2008:3216-3220
Efficient and scalable chemical approaches to 3,5,7-trisubstituted1H-indazoles were developed and applied to the synthesis of 1,1-dimethylethyl4-[7-(aminocarbonyl)-5-bromo-1 H-indazol-3-yl]-1-piperidinecarboxylate,a key intermediate for 3,5,7-trisubs
Autor:
Palovich Michael R, Miriam Burman, Edward F. Webb, Roderick S. Davis, Henry M. Sarau, Yonghui Wang, Wei Fu, Dwight M. Morrow, Jian Jin, Feng Wang, Qi Jin, Kristen E. Belmonte, Parvathi Rao, Michael L. Moore, Manuela Berlanga, James J. Foley, Chris J. Dehaas, Michael Salmon, Ralph A. Rivero, Lorena A. Kallal, Jakob Busch-Petersen, Dongchuan Shi
Publikováno v:
Journal of Medicinal Chemistry. 51:4866-4869
High throughput screening and subsequent optimization led to the discovery of novel quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excellent selectivity. Compounds 8a, 13a, and 13b showed excellent inhib