The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

Autor: Seyed Mojtaba Ghiasi, Jakob Bondo Hansen, Dan Ploug Christensen, Björn Tyrberg, Thomas Mandrup-Poulsen

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 12, p 4311 (2020)

Background: Intercellular communication mediated by cationic fluxes through the Connexin family of gap junctions regulates glucose-stimulated insulin secretion and beta cell defense against inflammatory stress. Rotigaptide (RG, ZP123) is a peptide an

Externí odkaz: https://doaj.org/article/5c165ff5cd914301a34443892d7c8b47

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Autor: Seth McGonigle, Susanne Mandrup, Olivia Sveidahl Johansen, Laia Reverte-Salisa, Rudolf Zechner, Lasse K. Markussen, Thomas Nielsen, Eline N. Kuipers, Andreas Kjaer, Maria Razzoli, Alexander Pfeifer, Jakob Bondo Hansen, Cheryl Cero, Alessandro Bartolomucci, James G. Granneman, Brice Emanuelli, Raymond E. Soccio, Morten Lundh, Thue Walter Schwartz, Søren Nielsen, Wenfei Sun, Dan Ploug Christensen, Hua Dong, Christa Broholm, Thorsten Gnad, Nienke Willemsen, Camilla Scheele, William Orchard, Oksana Dmytriyeva, Iuliia Karavaeva, Patrick C.N. Rensen, Marie S. Isidor, Sander Kooijman, Niels Grarup, Mikkel Frost, Cecilie Mørch Hallgren, Davide Calebiro, Tao Ma, Naja Z. Jespersen, M. Madan Babu, Mikael Rydén, Shannon L. O'Brien, Carsten H. Nielsen, Renate Schreiber, Zachary Gerhart-Hines, Jacob B. Hansen, Jonas T. Treebak, Yachen Shen, Torben Hansen, Oluf Pedersen, Elahu G. Sustarsic

Publikováno v: Sveidahl Johansen, O, Ma, T, Hansen, J B, Markussen, L K, Schreiber, R, Reverte-Salisa, L, Dong, H, Christensen, D P, Sun, W, Gnad, T, Karavaeva, I, Nielsen, T S, Kooijman, S, Cero, C, Dmytriyeva, O, Shen, Y, Razzoli, M, O'Brien, S L, Kuipers, E N, Nielsen, C H, Orchard, W, Willemsen, N, Jespersen, N Z, Lundh, M, Sustarsic, E G, Hallgren, C M, Frost, M, McGonigle, S, Isidor, M S, Broholm, C, Pedersen, O, Hansen, J B, Grarup, N, Hansen, T, Kjær, A, Granneman, J G, Babu, M M, Calebiro, D, Nielsen, S, Rydén, M, Soccio, R, Rensen, P C N, Treebak, J T, Schwartz, T W, Emanuelli, B, Bartolomucci, A, Pfeifer, A, Zechner, R, Scheele, C, Mandrup, S & Gerhart-Hines, Z 2021, ' Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis ', Cell, vol. 184, no. 13, pp. 3502-3518 . https://doi.org/10.1016/j.cell.2021.04.037
Cell
Sveidahl Johansen, O, Ma, T, Hansen, J B, Markussen, L K, Schreiber, R, Reverte-Salisa, L, Dong, H, Christensen, D P, Sun, W, Gnad, T, Karavaeva, I, Nielsen, T S, Kooijman, S, Cero, C, Dmytriyeva, O, Shen, Y, Razzoli, M, O'Brien, S L, Kuipers, E N, Nielsen, C H, Orchard, W, Willemsen, N, Jespersen, N Z, Lundh, M, Sustarsic, E G, Hallgren, C M, Frost, M, McGonigle, S, Isidor, M S, Broholm, C, Pedersen, O, Hansen, J B, Grarup, N, Hansen, T, Kjær, A, Granneman, J G, Babu, M M, Calebiro, D, Nielsen, S, Rydén, M, Soccio, R, Rensen, P C N, Treebak, J T, Schwartz, T W, Emanuelli, B, Bartolomucci, A, Pfeifer, A, Zechner, R, Scheele, C, Mandrup, S & Gerhart-Hines, Z 2021, ' Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis ', Cell, vol. 184, no. 13, pp. 3502-3518 + . https://doi.org/10.1016/j.cell.2021.04.037
Cell, 184 (13)
Cell, 184(13), 3502-3518.e33. CELL PRESS
Nat Rev Endocrinol

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fad4327df6593d39587aa7ce062641
https://findresearcher.sdu.dk:8443/ws/files/184106202/PIIS0092867421005729.pdf

Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

Autor: Jinyi Zhang, Brice Emanuelli, Signe S. Torekov, Geke Aline Boer, Jakob Bondo Hansen, Maria Villadsen, Thomas Nielsen, Jørgen K. Kanters, Thomas Jespersen, Anniek F. Lubberding, Jens J. Holst, Mathilde S Søndergaard, Jonas T. Treebak, Morten B. Thomsen, Thomas Mandrup-Poulsen, Emil Z Skovhøj, Morten Lundh

Publikováno v: Scientific Reports
Lubberding, A F, Zhang, J, Lundh, M, Nielsen, T S, Søndergaard, M S, Villadsen, M, Skovhøj, E Z, Boer, G A, Hansen, J B, Thomsen, M B, Treebak, J T, Holst, J J, Kanters, J K, Mandrup-Poulsen, T, Jespersen, T, Emanuelli, B & Torekov, S S 2021, ' Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V ', Scientific Reports, vol. 11, no. 1, 12253 . https://doi.org/10.1038/s41598-021-90452-8
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K+ channel Kv7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9902ca1f08671d1ab0a31c6c493dbc02
https://pubmed.ncbi.nlm.nih.gov/34112814

Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis

Autor: Deborah C. Rubin, Jakob Bondo Hansen, Subhankar Dolai, Herbert Y. Gaisano, Tairan Qin, Huanli Xie, Youhou Kang, Tao Liang, Lucy R. Osborne, Li Xie, Dan Zhu

Publikováno v: Diabetes

Of the four syntaxins specialized for exocytosis, syntaxin (Syn)-2 is the least understood. In this study, we used Syn-2/epimorphin knockout mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis. Unexpectedly, Syn-2 knockout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df4435bd3122515c0d2f45a8266cd78
https://doi.org/10.2337/db16-0636

Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development

Autor: Battsetseg Batchuluun, Jakob Bondo Hansen, Judith A. Eversley, Brian J. Cox, Kacey J. Prentice, Katherine Leavey, Ying Liu, Cheng Hu, Weiping Jia, David W. Wei, Michael B. Wheeler, Feihan F. Dai

Publikováno v: Cell Reports, Vol 14, Iss 12, Pp 2889-2900 (2016)

SummaryPrediabetes, a state of mild glucose intolerance, can persist for years before a sudden decline in beta cell function and rapid deterioration to overt diabetes. The mechanism underlying this tipping point of beta cell dysfunction remains unkno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5e3cec4fdeefdb07b66acabd248445
https://doi.org/10.1016/j.celrep.2016.02.079