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Investigation of the Organocatalytic Chlorination of 2-Phenylpropanal

Autor: Jakob Blom, Lisa-Marie Mohr, Karl Anker Jørgensen, Johannes N. Lamhauge, Christina H. McCulley

Publikováno v: Mohr, L M, McCulley, C H, Blom, J, Lamhauge, J N & Anker Jørgensen, K 2021, ' Investigation of the Organocatalytic Chlorination of 2-Phenylpropanal ', Chemistry-A European Journal, vol. 27, no. 69, pp. 17465-17475 . https://doi.org/10.1002/chem.202103376

Results of an examination of the organocatalytic enantioselective α-chlorination of 2-phenylpropanal are described. Synthetic investigation including the screening of primary and secondary aminocatalysts, many different reaction conditions, and othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a0e1e209f1f5b96b341d2dd120966a
https://pubmed.ncbi.nlm.nih.gov/34622997

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Umpolung Strategy for α-Functionalization of Aldehydes for the Addition of Thiols and other Nucleophiles

Autor: Matilde Rusbjerg, Jakob Blom, Casper L. Barløse, Karl Anker Jørgensen, Henriette N. Tobiesen, Marc V. Iversen, Niels Hammer, Gabriel J. Reyes-Rodríguez, Johannes N. Lamhauge

Publikováno v: Blom, J, Reyes Rodriguez, G J, Tobiesen, H N, Lamhauge, J N, Iversen, M V, Barløse, C L, Hammer, N, Rusbjerg, M & Jørgensen, K A 2019, ' Umpolung Strategy for α-Functionalization of Aldehydes for the Addition of Thiols and other Nucleophiles ', Angewandte Chemie-International Edition, vol. 58, no. 49, pp. 17856-17862 . https://doi.org/10.1002/anie.201911793

Nucleophile–nucleophile coupling is a challenging transformation in organic chemistry. Herein we present a novel umpolung strategy for α-functionalization of aldehydes with nucleophiles. The strategy uses organocatalytic enamine activation and qui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6637934f6e9d01618a42daf47b29a1e2
https://pure.au.dk/portal/da/publications/umpolung-strategy-for-functionalization-of-aldehydes-for-the-addition-of-thiols-and-other-nucleophiles(392d5730-182a-4517-8029-cd1380085d7f).html

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Dynamic resolution of 2-cyclohexylidene acetaldehydes through organocatalytic dienamine [4+2] cycloaddition

Autor: Tore Kiilerich Johansen, Frank Jensen, Karl Anker Jørgensen, Jakob Blom

Publikováno v: Blom, J, Johansen, T K, Jensen, F & Jørgensen, K A 2016, ' Dynamic resolution of 2-cyclohexylidene acetaldehydes through organocatalytic dienamine [4+2] cycloaddition ', Chemical Communications, vol. 52, no. 44, pp. 7153-7156 . https://doi.org/10.1039/c6cc02019d

Organocatalytic formed dienamines are shown to be involved in dynamic resolution of 2-cyclohexylidene acetaldehydes. By reaction of racemic 2-cyclohexylidene acetaldehydes with benzoquinones in the presence of a diarylprolinol-silyl ether catalyst, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428ebaa971105448fcfa4ae6cf938b19
https://doi.org/10.1039/c6cc02019d

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Directing the Activation of Donor-Acceptor Cyclopropanes Towards Stereoselective 1,3-Dipolar Cycloaddition Reactions by Brønsted Base Catalysis

Autor: Karl Anker Jørgensen, Jakob Blom, Marc V. Iversen, Julie Jørgensen, Casper L. Barløse, Kamilla S. Jessen, Andreu Vidal-Albalat

Publikováno v: Blom, J, Vidal-Albalat, A, Jørgensen, J, Barløse, C L, Jessen, K S, Iversen, M V & Jørgensen, K A 2017, ' Directing the Activation of Donor–Acceptor Cyclopropanes Towards Stereoselective 1,3-Dipolar Cycloaddition Reactions by Brønsted Base Catalysis ', Angewandte Chemie-International Edition, vol. 56, no. 39, pp. 11831-11835 . https://doi.org/10.1002/anie.201706150

The first stereoselective organocatalyzed [3+2] cycloaddition reaction of donor-acceptor cyclopropanes is presented. It is demonstrated that by applying an optically active bifunctional Brønsted base catalyst, racemic di-cyano cyclopropylketones can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0169c42b8da76ba4d397ecae7d64a564
https://pubmed.ncbi.nlm.nih.gov/28741849

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Synergistic Catalysis for the Asymmetric [3+2] Cycloaddition of Vinyl Aziridines with α,β-Unsaturated Aldehydes

Autor: Karl Anker Jørgensen, Marta Meazza, Jakob Blom, Line Næsborg, Kim Halskov, Fernando Tur

Publikováno v: Næsborg, L, Tur Espinosa, F, Meazza, M, Blom, J, Halskov, K S & Jørgensen, K A 2017, ' Synergistic Catalysis for the Asymmetric [3+2] Cycloaddition of Vinyl Aziridines with α,β-Unsaturated Aldehydes ', Chemistry: A European Journal, vol. 23, no. 2, pp. 268-272 . https://doi.org/10.1002/chem.201604995

The first asymmetric [3+2] cycloaddition of vinyl aziridines with alpha,beta-unsaturated aldehydes, based on synergistic catalysis, is disclosed. This methodology allows for the formation of attractive pyrrolidine structures in good yields (up to 84%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c697ba9d94d6bb35eb12658f80d2d3
https://pure.au.dk/portal/da/publications/synergistic-catalysis-for-the-asymmetric-32-cycloaddition-of-vinyl-aziridines-with-unsaturated-aldehydes(0455dea5-19c4-446d-b607-391a33844e53).html

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ChemInform Abstract: Dynamic Resolution of 2-Cyclohexylidene Acetaldehydes Through Organocatalytic Dienamine [4 + 2] Cycloaddition

Autor: Tore Kiilerich Johansen, Karl Anker Joergensen, Frank Jensen, Jakob Blom

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d7de3c4a278190e10f514af956ca2bc
https://doi.org/10.1002/chin.201640024

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Asymmetric Brønsted Base Catalyzed and Directed [3+2] Cycloaddition of 2-Acyl Cycloheptatrienes with Azomethine Ylides

Autor: Karl Anker Jørgensen, Lise Ibsen, Vibeke Henriette Lauridsen, Jakob Blom

Publikováno v: Lauridsen, V H, Ibsen, L, Blom, J & Jørgensen, K A 2016, ' Asymmetric Brønsted Base Catalyzed and Directed [3+2] Cycloaddition of 2-Acyl Cycloheptatrienes with Azomethine Ylides ', Chemistry: A European Journal, vol. 22, no. 10, pp. 3259-3263 . https://doi.org/10.1002/chem.201600255

Conjugated cyclic trienes have the potential for different types of cycloaddition reactions. In the present work, we will, in a novel asymmetric cycloaddition reaction, demonstrate that the organocatalytic reaction of 2-acyl cycloheptatrienes with az

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea38aef77ce50092514e6c97896ef33
https://pure.au.dk/portal/da/publications/asymmetric-broensted-base-catalyzed-and-directed-32-cycloaddition-of-2acyl-cycloheptatrienes-with-azomethine-ylides(36385bbf-eb2c-49b9-b96a-26b64e46d79b).html

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