Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Jakob B Sørensen"'
Publikováno v:
eLife, Vol 11 (2022)
Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane, which leads to neurotransmitter release. This exocytosis is triggered by brief and local elevations of intracellular Ca2+ with remarkably high sensitivity. How
Externí odkaz:
https://doaj.org/article/f322240008bc40b493a08149c9bc19e0
Autor:
Kwun Nok M Man, Cordelia Imig, Alexander M Walter, Paulo S Pinheiro, David R Stevens, Jens Rettig, Jakob B Sørensen, Benjamin H Cooper, Nils Brose, Sonja M Wojcik
Publikováno v:
eLife, Vol 4 (2015)
It is currently unknown whether the molecular steps of large dense-core vesicle (LDCV) docking and priming are identical to the corresponding reactions in synaptic vesicle (SV) exocytosis. Munc13s are essential for SV docking and priming, and we syst
Externí odkaz:
https://doaj.org/article/4de6334245e149208696e8936eba3a24
Autor:
Jens P Weber, Trine L Toft-Bertelsen, Ralf Mohrmann, Ignacio Delgado-Martinez, Jakob B Sørensen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e114033 (2014)
Synchronization of neurotransmitter release with the presynaptic action potential is essential for maintaining fidelity of information transfer in the central nervous system. However, synchronous release is frequently accompanied by an asynchronous r
Externí odkaz:
https://doaj.org/article/87f556e326804f769e8a679763a4d5df
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 12, p e1003362 (2013)
Neurotransmitter release depends on the fusion of secretory vesicles with the plasma membrane and the release of their contents. The final fusion step displays higher-order Ca(2+) dependence, but also upstream steps depend on Ca(2+). After deletion o
Externí odkaz:
https://doaj.org/article/cea08814fdff47f9a2f657288fe34dfd
Publikováno v:
PLoS Biology, Vol 4, Iss 10, p e330 (2006)
Munc18-1, a protein essential for regulated exocytosis in neurons and neuroendocrine cells, belongs to the family of Sec1/Munc18-like (SM) proteins. In vitro, Munc18-1 forms a tight complex with the SNARE syntaxin 1, in which syntaxin is stabilized i
Externí odkaz:
https://doaj.org/article/74b09e247649439991236c491b6ea3f9
Autor:
Anna Kádková, Jacqueline Murach, Maiken Ø. Pedersen, Andrea Malsam, Jörg Malsam, Thomas H. Söllner, Jakob B. Sørensen
SNAP25 is one of three neuronal SNAREs driving synaptic vesicle exocytosis. We studied three mutations in SNAP25 that cause epileptic encephalopathy: V48F, and D166Y in the Synaptotagmin-1 (Syt1) binding interface, and I67N, which destabilizes the SN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049173f975cb4c78d2102d999bf450fb
https://doi.org/10.1101/2023.05.21.541607
https://doi.org/10.1101/2023.05.21.541607
Autor:
Julika Radecke, Raphaela Seeger, Anna Kádková, Ulrike Laugks, Amin Khosrozadeh, Kenneth N Goldie, Vladan Lučić, Jakob B Sørensen, Benoît Zuber
Publikováno v:
Radecke, Julika; Seeger, Raphaela; Kádková, Anna; Laugks, Ulrike; Khosrozadeh, Mohammadamin; Goldie, Kenneth N; Lučić, Vladan; Sørensen, Jakob B; Zuber, Benoît (2023). Morphofunctional changes at the active zone during synaptic vesicle exocytosis. EMBO reports, 24(5), e55719. Nature Publishing Group 10.15252/embr.202255719
Radecke, J, Seeger, R, Kádková, A, Laugks, U, Khosrozadeh, A, Goldie, K N, Lučić, V, Sørensen, J B & Zuber, B 2023, ' Morphofunctional changes at the active zone during synaptic vesicle exocytosis ', EMBO Reports, vol. 24, no. 5, e55719 . https://doi.org/10.15252/embr.202255719
Radecke, J, Seeger, R, Kádková, A, Laugks, U, Khosrozadeh, A, Goldie, K N, Lučić, V, Sørensen, J B & Zuber, B 2023, ' Morphofunctional changes at the active zone during synaptic vesicle exocytosis ', EMBO Reports, vol. 24, no. 5, e55719 . https://doi.org/10.15252/embr.202255719
Synaptic vesicle (SV) fusion with the plasma membrane (PM) proceeds through intermediate steps that remain poorly resolved. The effect of persistent high or low exocytosis activity on intermediate steps remains unknown. Using spray-mixing plunge-free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc776fc5e67c959fc226e8b1b46c4fd
https://boris.unibe.ch/179590/1/EMBO_Reports_-_2023_-_Radecke_-_Morphofunctional_changes_at_the_active_zone_during_synaptic_vesicle_exocytosis.pdf
https://boris.unibe.ch/179590/1/EMBO_Reports_-_2023_-_Radecke_-_Morphofunctional_changes_at_the_active_zone_during_synaptic_vesicle_exocytosis.pdf
Autor:
Susanne Ditlevsen, Janus R. L. Kobbersmed, Alexander M. Walter, Jakob B. Sørensen, Manon M. M. Berns
Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane, which leads to neurotransmitter release. This exocytosis is triggered by brief and local elevations of intracellular Ca2+ with remarkably high sensitivity. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ff2ed274a8f420288f93e6870b7b64c
https://doi.org/10.1101/2021.10.22.465434
https://doi.org/10.1101/2021.10.22.465434
Autor:
Cordelia Imig, Sonja M. Wojcik, Sébastien Houy, Benjamin H. Cooper, Paulo S. Pinheiro, Joana S Martins, Jakob B. Sørensen, Nils Brose, Bassam Tawfik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad5f560d136b8a461fb8ba2174430345
https://doi.org/10.7554/elife.64527.sa2
https://doi.org/10.7554/elife.64527.sa2