Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jakob Albrethsen"'
Autor:
Malene Lundgaard Riis, Gaspard Delpouve, John E. Nielsen, Cecilie Melau, Lea Langhoff Thuesen, Kristine Juul Hare, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Paolo Giacobini, Anne Jørgensen
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously inhibiting the opposite pathway. In mice, the WNT/β-catenin pathway promotes ovarian devel
Externí odkaz:
https://doaj.org/article/9ba84127f86e43e4b357207164f53583
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionThe peptide hormone Insulin-like Factor 3 (INSL3) is a biomarker of testicular Leydig cells in the male but is also expressed by the theca cells of the ovaries. With the advent of sensitive assays INSL3 can be quantified in female circula
Externí odkaz:
https://doaj.org/article/97ae71162b11451cae9e368062dfadff
Autor:
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jørgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul
Publikováno v:
Endocrine Connections, Vol 12, Iss 8, Pp 1-10 (2023)
Congenital adrenal hyperplasia (CAH) is a recessive condition t hat affects the adrenal glands. Despite life-long replacement therapy with glucocorticoids and mineralocorticoids, adult patients with CAH often experience impaired gonadal function. In
Externí odkaz:
https://doaj.org/article/94afbdaa96a6497a8931b4288a0245a4
Autor:
Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell, Anne Jørgensen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported by studies in rats dem
Externí odkaz:
https://doaj.org/article/6faa0696ef594229b30882d592bea05d
Autor:
Lloyd J.W. Tack, Anne-Françoise Spinoit, Piet Hoebeke, Stefan Riedl, Alexander Springer, Ursula Tonnhofer, Manuela Hiess, Julia Weninger, Ahmed Mahmoud, Kelly Tilleman, Erik Van Laecke, Anders Juul, Jakob Albrethsen, Elfride De Baere, Julie Van De Velde, Hannah Verdin, Martine Cools
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104119- (2022)
Summary: Background: Hypospadias affects around 1/200 newborn males. Intrauterine testicular dysfunction may underlie a subset of cases. The long-term endocrine and reproductive outcomes in these men remain largely unknown. Methods: Cross-sectional s
Externí odkaz:
https://doaj.org/article/0b318dd053484dbfbf35780bb84bd592
Autor:
Marie Lindhardt Ljubicic, Anne Jørgensen, Lise Aksglaede, John Erik Nielsen, Jakob Albrethsen, Anders Juul, Trine Holm Johannsen
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
ObjectiveInsulin-like factor 3 (INSL3) is produced in the testes and has been proposed as a circulating biomarker of Leydig cell capacity, but remains undescribed in 45,X/46,XY mosaicism. The aim was to examine serum concentrations and gonadal expres
Externí odkaz:
https://doaj.org/article/0daecaa793364c4391af35a74bc5d604
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The structure of the testicular peptide hormone insulin-like factor 3 (INSL3) has been the subject of discussion for more than a decade. Some studies support that the central C-domain of INSL3 is proteolytically removed and that INSL3 is secreted by
Externí odkaz:
https://doaj.org/article/63d6858157334434bd8422fd4463a10c
Autor:
Li Juel Mortensen, Mette Lorenzen, Anne Jørgensen, Jakob Albrethsen, Niels Jørgensen, Søren Møller, Anna-Maria Andersson, Anders Juul, Martin Blomberg Jensen
Publikováno v:
Cancers, Vol 13, Iss 6, p 1329 (2021)
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are agonists for the luteinizing hormone receptor (LHCGR) which regulates male reproductive function. LHCGR may be released into body fluids. We wish to determine whether soluble LHCGR i
Externí odkaz:
https://doaj.org/article/f917973e099d431f9eac3be0e31fb92a
Autor:
Jakob Albrethsen, Peter Busch Østergren, Pernille Badsberg Norup, Jens Sønksen, Mikkel Fode, Caroline Kistorp, Nikolai B Nordsborg, Sara Amalie Solheim, Jakob Mørkeberg, Katharina M Main, Anders Juul
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Background Serum INSL3 is a Leydig cell biomarker, but little is known about the circulating concentration of INSL3 during hypothalamus-pituitary-testicular suppression. Aim To study the concomitant changes in serum concentrations of INSL3, testoster
Autor:
Ann-Kristin Dicke, Jakob Albrethsen, Bradley L Hoare, Margot J Wyrwoll, Alexander S Busch, Daniela Fietz, Adrian Pilatz, Clara Bühlmann, Anders Juul, Sabine Kliesch, Jörg Gromoll, Ross A D Bathgate, Frank Tüttelmann, Birgit Stallmeyer
Publikováno v:
Human Reproduction.
STUDY QUESTION What is the impact of variants in the genes INSL3 (Insulin Like 3) and RXFP2 (Relaxin Family Peptide Receptor 2), respectively, on cryptorchidism and male infertility? SUMMARY ANSWER Bi-allelic loss-of-function (LoF) variants in INSL3