Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challenges

Autor: Christian Hahn, Lena Heuchel, Jakob Ödén, Erik Traneus, Jörg Wulff, Sandija Plaude, Beate Timmermann, Christian Bäumer, Armin Lühr

Publikováno v: Radiation Oncology, Vol 17, Iss 1, Pp 1-13 (2022)

Abstract Background To introduce and compare multiple biological effectiveness guided (BG) proton plan optimization strategies minimizing variable relative biological effectiveness (RBE) induced dose burden in organs at risk (OAR) while maintaining p

Externí odkaz: https://doaj.org/article/056bff927b684bc0866ed3d022a5ce49

A NOVEL PLANNING TOOL FOR RADIOBIOLOGICAL OPTIMIZATION OF THERMORADIOTHERAPY TREATMENTS

Autor: Jakob Ödén, Brando Pavoni, Giorgia Meschini, Patricia Enríquez, Hans Crezee, Albin Fredriksson, Petra Kok, Kjell Eriksson

Publikováno v: Physica Medica. 104:S63-S64

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ef8f4979cc02d38a8a1cc32b19428b
https://doi.org/10.1016/s1120-1797(22)02261-x

Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: A European multi-centric study

Autor: Olga Sokol, Faiza Bourhaleb, Maria Fuglsang Jensen, Michael J. Merchant, A. M. M. Leite, Alexandru Dasu, Christian Hahn, Jakob Ödén, Chris J Rose, Claudia Pardi, E. Smith, Armin Lühr, Leszek Grzanka, Karen J. Kirkby, Anne Vestergaard, Jörg Pawelke, A. Aitkenhead, Ludovic De Marzi

Publikováno v: Acta Oncologica 61(2022)2, 206-214
Acta oncologica / Supplement 61(2), 206-214 (2022). doi:10.1080/0284186X.2021.1992007
Hahn, C, Dasu, A, Vestergaard, A, Fulsang Jensen, M, Sokol, O, Pardi, C, Bourhaleb, F, Leite, A, de Marzi, L, Smith, E, Aitkenhead, A, Rose, C, Merchant, M, Kirkby, K, Grzanka, L, Pawelke, J & Luhr, A 2021, ' Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: A European multi-centric study ', Acta Oncologica, pp. 1-9 . https://doi.org/10.1080/0284186X.2021.1992007
Acta Oncol
Hahn, C, Ödén, J, Dasu, A, Vestergaard, A, Fuglsang Jensen, M, Sokol, O, Pardi, C, Bourhaleb, F, Leite, A, de Marzi, L, Smith, E, Aitkenhead, A, Rose, C, Merchant, M, Kirkby, K, Grzanka, L, Pawelke, J & Lühr, A 2022, ' Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy : a European multi-centric study ', Acta Oncologica, vol. 61, no. 2, pp. 206-214 . https://doi.org/10.1080/0284186X.2021.1992007

Background: Clinical data suggest that the relative biological effectiveness (RBE) in proton therapy (PT) varies with linear energy transfer (LET). However, LET calculations are neither standardized nor available in clinical routine. Here, the status

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f851347d18c5a036ae34028a2ad8452
https://www.hzdr.de/publications/Publ-32813-1

Introducing Proton Track-End Objectives in Intensity Modulated Proton Therapy Optimization to Reduce Linear Energy Transfer and Relative Biological Effectiveness in Critical Structures

Autor: Erik Traneus, Jakob Ödén

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 103:747-757

Purpose We propose the use of proton track-end objectives in intensity modulated proton therapy (IMPT) optimization to reduce the linear energy transfer (LET) and the relative biological effectiveness (RBE) in critical structures. Methods and Materia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c319e6940304b69d59d3bd373823711
https://doi.org/10.1016/j.ijrobp.2018.10.031

Incorporation of relative biological effectiveness uncertainties into proton plan robustness evaluation

Autor: Kjell Eriksson, Iuliana Toma-Dasu, Jakob Ödén

Publikováno v: Acta Oncologica. 56:769-778

Background: The constant relative biological effectiveness (RBE) of 1.1 is typically assumed in proton therapy. This study presents a method of incorporating the variable RBE and its uncertainties into the proton plan robustness evaluation. Material

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e6c45adb7f3ff1e0976907e2c4ce32
https://doi.org/10.1080/0284186x.2017.1290825