Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jakob, Wolfart"'
Autor:
Frederik Tolle, Jakob Wolfart, Michael Stegen, Rüdiger Köhling, Marco Heerdegen, Timo Kirschstein, Debora Laker
Publikováno v:
Neuroscience. 467:56-72
The slow afterhyperpolarizing potential (sAHP) can silence a neuron for hundreds of milliseconds. Thereby, the sAHP determines the discharge behavior of many types of neurons. In dentate granule cells (DGCs), serving as a filter into the hippocampal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10bb5d840a17a8e3d89751c4db9ab1b2
https://doi.org/10.1016/j.neuroscience.2021.05.025
https://doi.org/10.1016/j.neuroscience.2021.05.025
Autor:
Debora, Laker, Frederik, Tolle, Michael, Stegen, Marco, Heerdegen, Rüdiger, Köhling, Timo, Kirschstein, Jakob, Wolfart
Publikováno v:
Neuroscience. 467
The slow afterhyperpolarizing potential (sAHP) can silence a neuron for hundreds of milliseconds. Thereby, the sAHP determines the discharge behavior of many types of neurons. In dentate granule cells (DGCs), serving as a filter into the hippocampal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::309665be2605dcd9757bd7fa2bedcbbe
https://pubmed.ncbi.nlm.nih.gov/34048798
https://pubmed.ncbi.nlm.nih.gov/34048798
Autor:
Annett Madadi, Michael Linnebacher, Jakob Wolfart, Rüdiger Köhling, Anja U. Bräuer, Timo Kirschstein, Thomas M. Freiman, Hannes Brehme, Steffen Müller, Andreas Büttner, Falko Lange, Christian Henker, Simone Rackow, Anne Einsle
Publikováno v:
Neuroscience letters. 741
Gliomas are the most common primary brain tumors and often become apparent through symptomatic epileptic seizures. Glial cells express the inwardly rectifying K+ channel Kir4.1 playing a major role in K+ buffering, and are presumably involved in faci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6481779b5773e24b818a795e5ce480
https://pubmed.ncbi.nlm.nih.gov/33161102
https://pubmed.ncbi.nlm.nih.gov/33161102
Publikováno v:
Springer Series in Computational Neuroscience ISBN: 9783319991023
The model is a conductance-based neural network model of the brain circuit thought to be involved in pattern separation during hippocampal memory acquisition: the dentate gyrus (DG). In this chapter we explain the concepts of pattern separation and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ead3683f2dda6222b3e17eadeb1d83d
https://doi.org/10.1007/978-3-319-99103-0_23
https://doi.org/10.1007/978-3-319-99103-0_23
Publikováno v:
Hippocampus. 25:297-308
The dentate gyrus (DG) is thought to enable efficient hippocampal memory acquisition via pattern separation. With patterns defined as spatiotemporally distributed action potential sequences, the principal DG output neurons (granule cells, GCs), presu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f59340212a80b81607d34338f5156fc2
https://doi.org/10.1002/hipo.22373
https://doi.org/10.1002/hipo.22373
Autor:
Ori Staszewski, Jakob Wolfart, Rüdiger W. Veh, Michael Stegen, Alexander Hanuschkin, Florian Kirchheim
Publikováno v:
Cerebral Cortex. 22:2087-2101
Granule cells in the dentate gyrus are only sparsely active in vivo and survive hippocampal sclerosis (HS) during temporal lobe epilepsy better than neighboring cells. This phenomenon could be related to intrinsic properties specifically adapted to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107c2259f95364dc319a98f9fd4f0e1c
https://doi.org/10.1093/cercor/bhr294
https://doi.org/10.1093/cercor/bhr294
Publikováno v:
Cerebral Cortex. 22:26-36
It is a matter of ongoing debate whether newly generated granule cells contribute to epileptic activity in the hippocampus. To address this question, we investigated neurogenesis and epileptiform activity (EA) along the hippocampal septotemporal axis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc73a4029c78d2ebd1bc9e10868f2a0b
https://doi.org/10.1093/cercor/bhr054
https://doi.org/10.1093/cercor/bhr054
Autor:
Michael Stegen, Carola A. Haas, Rüdiger W. Veh, Christina Young, René Bernard, Jakob Wolfart, Josef Bischofberger, Martin Müller
Publikováno v:
The Journal of Physiology. 587:4213-4233
In humans, temporal lobe epilepsy (TLE) is often associated with Ammon's horn sclerosis (AHS) characterized by hippocampal cell death, gliosis and granule cell dispersion (GCD) in the dentate gyrus. Granule cells surviving TLE have been proposed to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfb371c1637bb0a16690dd39fbc9b993
https://doi.org/10.1113/jphysiol.2009.170746
https://doi.org/10.1113/jphysiol.2009.170746
Publikováno v:
Homeostatic Control of Brain Function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16c196bd41d50a5f6a7889c773c23ba
https://doi.org/10.1093/med/9780199322299.003.0004
https://doi.org/10.1093/med/9780199322299.003.0004
Autor:
Jakob Wolfart, Debora Laker
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Frontiers in Physiology
Frontiers in Physiology
Neurons continuously adapt the expression and functionality of their ion channels. For example, exposed to chronic excitotoxicity, neurons homeostatically downscale their intrinsic excitability. In contrast, the ‘acquired channelopathy’ hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff881586dbcdd1c8cab7b5d87923861
http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00168/full
http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00168/full