Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jakob, Morgenstern"'
Autor:
Xin Qian, Stephan Klatt, Katrin Bennewitz, David Philipp Wohlfart, Bowen Lou, Ye Meng, Michael Buettner, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ingrid Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Advanced Science, Vol 11, Iss 4, Pp n/a-n/a (2024)
Abstract Omega‐6 fatty acids are the primary polyunsaturated fatty acids in most Western diets, while their role in diabetes remains controversial. Exposure of omega‐6 fatty acids to an oxidative environment results in the generation of a highly
Externí odkaz:
https://doaj.org/article/d3e9abcfffc843caa8b54bf9e9a82f24
Autor:
Christoph Tobias Tabler, Elisabeth Lodd, Katrin Bennewitz, Chiara Simone Middel, Vanessa Erben, Hannes Ott, Tanja Poth, Thomas Fleming, Jakob Morgenstern, Ingrid Hausser, Carsten Sticht, Gernot Poschet, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102576- (2023)
Glyoxalase 2 is the second enzyme of the glyoxalase system, catalyzing the detoxification of methylglyoxal to d-lactate via SD-Lactoylglutathione. Recent in vitro studies have suggested Glo2 as a regulator of glycolysis, but if Glo2 regulates glucose
Externí odkaz:
https://doaj.org/article/8ec9121e06394c43ad839a73926f3863
Autor:
Gretchen Wolff, Minako Sakurai, Amit Mhamane, Maria Troullinaki, Adriano Maida, Ioannis K. Deligiannis, Kelvin Yin, Peter Weber, Jakob Morgenstern, Annika Wieder, Yun Kwon, Revathi Sekar, Anja Zeigerer, Michael Roden, Matthias Blüher, Nadine Volk, Tanja Poth, Thilo Hackert, Lena Wiedmann, Francesca De Angelis Rigotti, Juan Rodriguez-Vita, Andreas Fischer, Rajesh Mukthavaram, Pattraranee Limphong, Kiyoshi Tachikawa, Priya Karmali, Joseph Payne, Padmanabh Chivukula, Bilgen Ekim-Üstünel, Celia P. Martinez-Jimenez, Julia Szendrödi, Peter Nawroth, Stephan Herzig
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101487- (2022)
Objective: Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic fatty liver disease (
Externí odkaz:
https://doaj.org/article/7ffd9988b903457a8a6a90287967ed13
Autor:
Khalid O. Alfarouk, Saad S. Alqahtani, Saeed Alshahrani, Jakob Morgenstern, Claudiu T. Supuran, Stephan J. Reshkin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2010-2015 (2021)
Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps ma
Externí odkaz:
https://doaj.org/article/fd56f976f04e41f09b3b4e4ea3214d1b
Autor:
David Philipp Wohlfart, Bowen Lou, Chiara Simone Middel, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Rüdiger Hell, Hans-Peter Hammes, Julia Szendrödi, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102249- (2022)
Reactive carbonyl species (RCS) are spontaneously formed in the metabolism and modify and impair the function of DNA, proteins and lipids leading to several organ complications. In zebrafish, knockout of the RCS detoxifying enzymes glyoxalase 1 (Glo
Externí odkaz:
https://doaj.org/article/3d1cdcad30e44060993f91c00777083e
Autor:
Fabiola Garcia Cortizo, Daniel Pfaff, Angela Wirth, Andrea Schlotterer, Rebekka Medert, Jakob Morgenstern, Tobias Weber, Hans-Peter Hammes, Thomas Fleming, Peter Paul Nawroth, Marc Freichel, Aurelio A. Teleman
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101406- (2022)
Objective: Methylglyoxal (MG) is a highly reactive α-oxoaldehyde that glycates proteins. MG has been linked to the development of diabetic complications: MG is the major precursor of advanced glycation end products (AGEs), a risk marker for diabetic
Externí odkaz:
https://doaj.org/article/6586086fec034e6e93d18634639a1dce
Autor:
Johann M. E. Jende, Zoltan Kender, Jakob Morgenstern, Pascal Renn, Christoph Mooshage, Alexander Juerchott, Stefan Kopf, Peter P. Nawroth, Martin Bendszus, Felix T. Kurz
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
BackgroundRecent studies have found that troponin T parallels the structural and functional decay of peripheral nerves at the level of the lower limbs in patients with type 2 diabetes (T2D). The aim of this study was to determine whether this finding
Externí odkaz:
https://doaj.org/article/114f4a5aecf5486e91842aff7a293458
Autor:
Haozhe Qi, Felix Schmöhl, Xiaogang Li, Xin Qian, Christoph T. Tabler, Katrin Bennewitz, Carsten Sticht, Jakob Morgenstern, Thomas Fleming, Nadine Volk, Ingrid Hausser, Elena Heidenreich, Rüdiger Hell, Peter Paul Nawroth, Jens Kroll
Publikováno v:
Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021)
Abstract Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications. However, the molecular mechanisms are mostly unknown, and a suitable animal model with internal increased ACR do
Externí odkaz:
https://doaj.org/article/5965a1df7cfd4a61ae1372f68cdba8f5
Autor:
Felix Carl Fabian Schmitt, Vasil Manolov, Jakob Morgenstern, Thomas Fleming, Stefan Heitmeier, Florian Uhle, Mohammed Al-Saeedi, Thilo Hackert, Thomas Bruckner, Herbert Schöchl, Markus Alexander Weigand, Stefan Hofer, Thorsten Brenner
Publikováno v:
Annals of Intensive Care, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Background Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt disseminated intravascular coagulation. Acute fibrinolysis shu
Externí odkaz:
https://doaj.org/article/31f2cce893104c00a271c0b9ce8abe04
Autor:
Dagmar Schumacher, Jakob Morgenstern, Yoko Oguchi, Nadine Volk, Stefan Kopf, Jan Benedikt Groener, Peter Paul Nawroth, Thomas Fleming, Marc Freichel
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 143-152 (2018)
Objectives: The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have been shown to
Externí odkaz:
https://doaj.org/article/ab909cb76d024a0a9c7acda54454efcc