Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Jakob, Michaëlsson"'
Autor:
Joanna Hård, Jeff E. Mold, Jesper Eisfeldt, Christian Tellgren-Roth, Susana Häggqvist, Ignas Bunikis, Orlando Contreras-Lopez, Chen-Shan Chin, Jessica Nordlund, Carl-Johan Rubin, Lars Feuk, Jakob Michaëlsson, Adam Ameur
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Long-read sequencing has dramatically increased our understanding of human genome variation. Here, we demonstrate that long-read technology can give new insights into the genomic architecture of individual cells. Clonally expanded CD8+ T-cel
Externí odkaz:
https://doaj.org/article/efffad5a10524d999abe2caf7681ce2d
Autor:
Demi Brownlie, Andreas von Kries, Giampiero Valenzano, Nicole Wild, Emel Yilmaz, Jesper Säfholm, Mamdoh Al-Ameri, Evren Alici, Hans-Gustaf Ljunggren, Igor Schliemann, Ozan Aricak, Felix Haglund de Flon, Jakob Michaëlsson, Nicole Marquardt
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTLung cancer is a leading cause of cancer-related death worldwide. Despite recent advances in tissue immunology, little is known about the spatial distribution of tissue-resident lymphocyte subsets in lung tumors. Using high-parameter flow cyt
Externí odkaz:
https://doaj.org/article/000ae8fd19714447920bbd41b44f02c9
Autor:
Laura M. Palma Medina, Haris Babačić, Majda Dzidic, Åsa Parke, Marina Garcia, Kimia T. Maleki, Christian Unge, Magda Lourda, Egle Kvedaraite, Puran Chen, Jagadeeswara Rao Muvva, Martin Cornillet, Johanna Emgård, Kirsten Moll, Karolinska K. I./K. COVID-19 Study Group, Jakob Michaëlsson, Malin Flodström-Tullberg, Susanna Brighenti, Marcus Buggert, Jenny Mjösberg, Karl-Johan Malmberg, Johan K. Sandberg, Sara Gredmark-Russ, Olav Rooyackers, Mattias Svensson, Benedict J. Chambers, Lars I. Eriksson, Maria Pernemalm, Niklas K. Björkström, Soo Aleman, Hans-Gustaf Ljunggren, Jonas Klingström, Kristoffer Strålin, Anna Norrby-Teglund
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the pathoph
Externí odkaz:
https://doaj.org/article/d9502f7d22f248878bad4b825dd78148
Autor:
Quirin Hammer, Josefine Dunst, Wanda Christ, Francesca Picarazzi, Mareike Wendorff, Pouria Momayyezi, Oisín Huhn, Herman K. Netskar, Kimia T. Maleki, Marina García, Takuya Sekine, Ebba Sohlberg, Valerio Azzimato, Myriam Aouadi, Frauke Degenhardt, Andre Franke, Francesco Spallotta, Mattia Mori, Jakob Michaëlsson, Niklas K. Björkström, Timo Rückert, Chiara Romagnani, Amir Horowitz, Jonas Klingström, Hans-Gustaf Ljunggren, Karl-Johan Malmberg
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110503- (2022)
Summary: Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute co
Externí odkaz:
https://doaj.org/article/d0512625ba2349d29221d3f301e7e0bf
Autor:
Demi Brownlie, Inga Rødahl, Renata Varnaite, Hilmir Asgeirsson, Hedvig Glans, Sara Falck-Jones, Sindhu Vangeti, Marcus Buggert, Hans-Gustaf Ljunggren, Jakob Michaëlsson, Sara Gredmark-Russ, Anna Smed-Sörensen, Nicole Marquardt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Respiratory viral infections with SARS-CoV-2 and influenza viruses commonly induce a strong infiltration of immune cells into the human lung, with potential detrimental effects on the integrity of the lung tissue. Despite comprising the largest fract
Externí odkaz:
https://doaj.org/article/44bdfa31e87344d4a0bee889cfed2656
Autor:
Arlisa Alisjahbana, Yu Gao, Natalie Sleiers, Elza Evren, Demi Brownlie, Andreas von Kries, Carl Jorns, Nicole Marquardt, Jakob Michaëlsson, Tim Willinger
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Innate lymphoid cells (ILCs) contribute to immune defense, yet it is poorly understood how ILCs develop and are strategically positioned in the lung. This applies especially to human ILCs due to the difficulty of studying them in vivo. Here we invest
Externí odkaz:
https://doaj.org/article/3581d61e11c14a16a813b6307072b0c7
Autor:
Nicole Marquardt, Eliisa Kekäläinen, Puran Chen, Magda Lourda, Jennifer N. Wilson, Marlena Scharenberg, Per Bergman, Mamdoh Al-Ameri, Joanna Hård, Jeffrey E. Mold, Hans-Gustaf Ljunggren, Jakob Michaëlsson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Detailed characterizations of human lung tissue-resident natural killer (trNK) cells, which potentially regulate local immune responses, is still lacking. Here the authors show that lung CD69+ CD16– NK cells express tissue-residency markers, produc
Externí odkaz:
https://doaj.org/article/152697cfa0e24e018fa257edf3a843b8
Autor:
Jeff E Mold, Pedro Réu, Axel Olin, Samuel Bernard, Jakob Michaëlsson, Sanket Rane, Andrew Yates, Azadeh Khosravi, Mehran Salehpour, Göran Possnert, Petter Brodin, Jonas Frisén
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000383 (2019)
Thymic involution and proliferation of naive T cells both contribute to shaping the naive T-cell repertoire as humans age, but a clear understanding of the roles of each throughout a human life span has been difficult to determine. By measuring nucle
Externí odkaz:
https://doaj.org/article/7967f405036848668c522851a8edc2de
Autor:
Chenhong Lin, Åsa Ekblad-Nordberg, Jakob Michaëlsson, Cecilia Götherström, Chia-Chen Hsu, Hua Ye, Jan Johansson, Anna Rising, Erik Sundström, Elisabet Åkesson
Publikováno v:
Cells, Vol 10, Iss 7, p 1713 (2021)
Scaffolds of recombinant spider silk protein (spidroin) and hyaluronic acid (HA) hydrogel hold promise in combination with cell therapy for spinal cord injury. However, little is known concerning the human immune response to these biomaterials and gr
Externí odkaz:
https://doaj.org/article/f38981fc33de413798b1afd8a236f148
Autor:
Marlena Scharenberg, Sindhu Vangeti, Eliisa Kekäläinen, Per Bergman, Mamdoh Al-Ameri, Niclas Johansson, Klara Sondén, Sara Falck-Jones, Anna Färnert, Hans-Gustaf Ljunggren, Jakob Michaëlsson, Anna Smed-Sörensen, Nicole Marquardt
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in IAV and other respiratory viral infections. Here,
Externí odkaz:
https://doaj.org/article/75d8d1d487404bc1b6b971ee2d42553e