Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jake Yeung"'
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 3, Pp 1-18 (2021)
Abstract The circadian clock is an endogenous and self‐sustained oscillator that anticipates daily environmental cycles. While rhythmic gene expression of circadian genes is well‐described in populations of cells, the single‐cell mRNA dynamics
Externí odkaz:
https://doaj.org/article/36fdc94623c04c04a5bbf604b6a559e6
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009350 (2021)
The circadian clock drives extensive temporal gene expression programs controlling daily changes in behavior and physiology. In mouse liver, transcription factors dynamics, chromatin modifications, and RNA Polymerase II (PolII) activity oscillate thr
Externí odkaz:
https://doaj.org/article/d635e8590dc94595b7afcaa818919d73
Autor:
Jake Yeung, Maria Florescu, Peter Zeller, Buys Anton de Barbanson, Max D. Wellenstein, Alexander van Oudenaarden
Publikováno v:
Nature Biotechnology
Regulation of chromatin states involves the dynamic interplay between different histone modifications to control gene expression. Recent advances have enabled mapping of histone marks in single cells, but most methods are constrained to profile only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f2be2364a94cc1b5fe35b192e8e88e
Recent advances have enabled mapping of histone modifications in single cells1–12, but current methods are constrained to profile only one histone modification per cell. Here we present an integrated experimental and computational framework, scChIX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb5c0dfd99ef17d2755e2a92f9a6e1b6
https://doi.org/10.1101/2021.04.26.440629
https://doi.org/10.1101/2021.04.26.440629
SUMMARYPost-translational histone modifications modulate chromatin packing to regulate gene expression. How chromatin states, at euchromatic and heterochromatic regions, underlie cell fate decisions in single cells is relatively unexplored. We develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42823e936dd45887bb50995d43cec87
https://doi.org/10.1101/2021.04.26.440606
https://doi.org/10.1101/2021.04.26.440606
The circadian clock is an endogenous and self-sustained oscillator that anticipates daily environmental cycles and coordinates physiology accordingly. While rhythmic gene expression of circadian genes is well-described in populations of cells, the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ca70d41366dc9286bc8a41ce01ae1e
https://doi.org/10.1101/2020.08.26.268201
https://doi.org/10.1101/2020.08.26.268201
Autor:
Felix Naef, Aline Charpagne, Frédéric Gachon, Julien Marquis, Jérôme Mermet, Céline Jouffe, Jake Yeung
Publikováno v:
Genome Research. 28:182-191
Temporal control of physiology requires the interplay between gene networks involved in daily timekeeping and tissue function across different organs. How the circadian clock interweaves with tissue-specific transcriptional programs is poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946bf856987d7951ac4b90f6b01c4591
https://doi.org/10.1101/gr.222430.117
https://doi.org/10.1101/gr.222430.117
Autor:
Maxime Jan, Felix Naef, Yann Emmenegger, Ioannis Xenarios, Paul Franken, Charlotte N. Hor, Jeffrey Hubbard, Jake Yeung
The timing and duration of sleep results from the interaction between a sleep-wake driven, or homeostatic, process (S) and a circadian process (C), and involves changes in gene expression and genomic regulation. Unraveling the respective contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1826111cbfc7defb5f5d02017978cf2
Autor:
Aline Charpagne, Francis Foata, Jake Yeung, Benjamin D. Weger, Felix Naef, Bertrand Betrisey, Eva Martin, Frédéric Gachon, Aurélie Balvay, Sonia Jimenez, Cédric Gobet, Bernard Berger, Chieh Jason Chou, Anne Foussier, Brigitte Boizet-Bonhoure
Publikováno v:
Cell Metabolism
Cell Metabolism, Elsevier, 2019, 29 (2), pp.362-382.e8. ⟨10.1016/j.cmet.2018.09.023⟩
Cell Metabolism, 2019, 29 (2), pp.362-382.e8. ⟨10.1016/j.cmet.2018.09.023⟩
Cell Metabolism, Elsevier, 2019, 29 (2), pp.362-382.e8. ⟨10.1016/j.cmet.2018.09.023⟩
Cell Metabolism, 2019, 29 (2), pp.362-382.e8. ⟨10.1016/j.cmet.2018.09.023⟩
Summary The circadian clock and associated feeding rhythms have a profound impact on metabolism and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of physiology in the host remains elusive. Here, we analyzed transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e11a41de2fe7741057ab44b5c8a711
https://hal.archives-ouvertes.fr/hal-02048230
https://hal.archives-ouvertes.fr/hal-02048230