Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jake Powrie"'
Autor:
Yuk-Fun Liu, Jake Powrie, Sefina Arif, Jennie H.M. Yang, Evangelia Williams, Leena Khatri, Mamta Joshi, Loic Lhuillier, Nikolaos Fountoulakis, Emma Smith, Craig Beam, Anna Lorenc, Mark Peakman, Timothy Tree
Publikováno v:
Diabetes. 71:722-732
Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in T regulatory cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tolerance, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b87ccec177121a6e30a6f57724a088f
https://doi.org/10.2337/db21-0728
https://doi.org/10.2337/db21-0728
Autor:
Mamta Joshi, Moira Thomson, Emma L. Smith, Yuk-Fun Liu, Mark Peakman, Nikolaos Fountoulakis, Jake Powrie, Sefina Arif, Foteini Strimenopoulou
Publikováno v:
Diabetes. 67
Background: Peptide immunotherapy (PIT) aims to modulate immune responses to specific antigens in order to restore immune tolerance. Recently, we reported outcomes of a phase 1b study of PIT at type 1 diabetes onset, showing safety, tolerability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e666f45b873b1a8635648c1312a00d0
https://doi.org/10.2337/db18-1733-p
https://doi.org/10.2337/db18-1733-p
Autor:
Barbara McGowan, Rakshit Kumar, Louise Izatt, Anand Velusamy, Mamta Joshi, Jake Powrie, Paul Carroll
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed419dd45629ddfad27d9eeb030c1c0b
https://doi.org/10.1530/endoabs.56.p139
https://doi.org/10.1530/endoabs.56.p139
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303fbb3dadb92f417c091c73c897b1c9
https://doi.org/10.1530/endoabs.55.wc2
https://doi.org/10.1530/endoabs.55.wc2
Autor:
Rupert Obholzer, Isra AhmedMohammed, Louise Izatt, Barbara McGowan, Paul Carroll, Jake Powrie, Anand Velusamy
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2bba2f151bdd41fd7864c40b0697d2c
https://doi.org/10.1530/endoabs.52.p05
https://doi.org/10.1530/endoabs.52.p05
Autor:
Shaina Rafique, Mamta Joshi, Louise Breen, Paul Carroll, Aarthi Surendran, Louise Izzat, Jake Powrie, Barbara McGowan, Anand Velusamy
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b2a64dd1980c06eccc01f7ad4fe7be7
https://doi.org/10.1530/endoabs.52.p01
https://doi.org/10.1530/endoabs.52.p01
Autor:
Anand Velusamy, Shaina Rafique, Louise Izatt, Aarthi Surendran, Paul Carroll, Barbara McGowan, Louise Breen, Jake Powrie, Mamta Joshi
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c700998c1010bfe5dae4f9911be7489
https://doi.org/10.1530/endoabs.50.cc05
https://doi.org/10.1530/endoabs.50.cc05
Autor:
Frank Joseph, Jake Powrie, Susan Seal, Sunil Nair, Zoe Boult, Mohammad Alhadj Ali, Hina Shariff, Jennie H M Yang, Martin Eichmann, Lucas Baumard, Graham Bayly, Kate Green, HoYee Cheung, Craig A. Beam, Rachel Stenson, Danijela Tatovic, Colin M. Dayan, Alison Clark, Lorraine Yeo, Alex Howell, Natasha Thorogood, Susanne Heck, Robert Kerrin Hills, Florence Susan Wong, Nedyalko Petrov, Laura Adams, Robert Andrews, Stephen D. Luzio, Alison O'Keefe, Roman Baptista, Sefina Arif, Yuk-Fun Liu, Vivienne B. Gibson, Timothy Tree, Gareth Dunseath, Irma Pujol-Autonell, Mark Peakman, Nicola Leech, Norkhairin Yusuf
Publikováno v:
Ali, M A, Liu, Y-F, Arif, S, Tatovic, D, Shariff, H, Gibson, V B, Yusuf, N, Baptista, R, Eichmann, M, Petrov, N, Heck, S, Yang, J H M, Tree, T I M, Pujol-Autonell, I, Yeo, L, Baumard, L R, Stenson, R, Howell, A, Clark, A, Boult, Z, Powrie, J, Adams, L, Wong, F S, Luzio, S, Dunseath, G, Green, K, O'Keefe, A, Bayly, G, Thorogood, N, Andrews, R, Leech, N, Joseph, F, Nair, S, Seal, S, Cheung, H, Beam, C, Hills, R, Peakman, M & Dayan, C M 2017, ' Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes ', Science Translational Medicine, vol. 9, no. 402, eaaf7779 . https://doi.org/10.1126/scitranslmed.aaf7779
Immunotherapy using short immunogenic peptides of disease-related autoantigens restores immune tolerance in preclinical disease models. We studied safety and mechanistic effects of injecting human leukocyte antigen-DR4(DRB1*0401)-restricted immunodom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c228a69b8635c0f3aeca67a06ec0e3a
https://kclpure.kcl.ac.uk/ws/files/140478917/Metabolic_and_immune_effect_ALI_Acc11Jul2017_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/140478917/Metabolic_and_immune_effect_ALI_Acc11Jul2017_GREEN_AAM.pdf
Autor:
Deborah Kronenberg-Versteeg, Sarah J. Richardson, Abby Willcox, Katherine Marks, John A. Todd, Noel G. Morgan, Nurhanani Mohamed Nor, Jake Powrie, Polly J. Bingley, Megan Estorninho, Alan K. Foulis, Pia Leete, David B. Dunger, Catherine Guy, Anna Lorenc, Sefina Arif, Mark Peakman, Vy Nguyen, Emanuele de Rinaldis
Publikováno v:
Diabetes
Studies in type 1 diabetes indicate potential disease heterogeneity, notably in the rate of β-cell loss, responsiveness to immunotherapies, and, in limited studies, islet pathology. We sought evidence for different immunological phenotypes using two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94fa308e9b9ee0c19c679b69636e2d8
http://europepmc.org/articles/PMC4207393
http://europepmc.org/articles/PMC4207393
Autor:
James E. McLaren, Kristin Ladell, Emma Gostick, Robin R. Knight, Ania Skowera, David Price, Katherine K. Matthews, Martin Eichmann, Andrew K. Sewell, Deborah Kronenberg-Versteeg, Garry Dolton, Colin M. Dayan, Polly J. Bingley, Mark Peakman, Susanne Heck, Jake Powrie, John J. Miles
Publikováno v:
Diabetes. 64:916-925
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that leads to type 1 diabetes, yet the key features of this immune-mediated process remain poorly defined. In this study, we combined high-definition polychr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dea629812a2376ea48ed423fab9e41
https://doi.org/10.2337/db14-0332
https://doi.org/10.2337/db14-0332