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Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1688-1691
We evaluated the effect of combining 2′- O -[2-[2-( N , N -dimethylamino)ethoxy]ethyl] (2′- O -DMAEOE), a 2′-cationic modification, with a 2′,4′-constrained 2′- O -ethyl nucleic acid (cEt BNA) on the activity of an antisense oligonucleoti