Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jake Metterville"'
Autor:
Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Issa Yusuf, Robert H Brown, Huaibin Cai, Zuoshang Xu
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0255710 (2022)
Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neuromuscular diseases. However, whether this modest elevation
Externí odkaz:
https://doaj.org/article/ca05dfe95e714d5a948fa5b42faad5b5
Autor:
Owen M. Peters, Alexandra Weiss, Jake Metterville, Lina Song, Robert Logan, Gaynor A. Smith, Michael A. Schwarzschild, Christian Mueller, Robert H. Brown, Marc Freeman
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105368- (2021)
Parkinson's disease (PD) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. Though loss of dopaminergic neuron cell bodies from the substantia nigra pars compa
Externí odkaz:
https://doaj.org/article/61bd0e8a5ddc42d987d5cc6ee8708517
Autor:
Wei Liu, Naoki Iwamoto, Subramanian Marappan, Khoa Luu, Snehlata Tripathi, Erin Purcell-Estabrook, Juili Dilip Shelke, Himali Shah, Anthony Lamattina, Qianli Pan, Brett Schrand, Frank Favaloro, Mugdha Bedekar, Arindom Chatterjee, Jigar Desai, Tomomi Kawamoto, Genliang Lu, Jake Metterville, Milinda Samaraweera, Priyanka Shiva Prakasha, Hailin Yang, Yuan Yin, Hui Yu, Paloma H Giangrande, Michael Byrne, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 51:4126-4147
Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52fce2dc6c2c20d3fb621264918bd6b
https://doi.org/10.1093/nar/gkad268
https://doi.org/10.1093/nar/gkad268
Autor:
Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Karley Bussow, Michael Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, Jigar Desai, Frank Favaloro, Jack Godfrey, Andrew Hoss, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Amber Lindsey, Fangjun Liu, Richard Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, Bijay Bhattarai, Stephany Standley, Snehlata Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, Luciano H. Apponi, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nature Biotechnology. 40:1093-1102
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to specific cellular RNAs have therapeutic potential, but translating them from cell culture into animal models has been challenging. Here we describe short, chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e36a5ee2c78d18679d808cc838638dd
https://doi.org/10.1038/s41587-022-01225-1
https://doi.org/10.1038/s41587-022-01225-1
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Hélène Tran, Michael P. Moazami, Huiya Yang, Diane McKenna-Yasek, Catherine L. Douthwright, Courtney Pinto, Jake Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley, Ajit Puri, Alexandra Weiss, Nicholas Wightman, Heather Gray-Edwards, Miklos Marosfoi, Robert M. King, Thomas Kenderdine, Daniele Fabris, Robert Bowser, Jonathan K. Watts, Robert H. Brown
Publikováno v:
Nat Med
Expansions of a G(4)C(2) repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders. Using C9-ALS/FTD patient derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526bfed36a1119fec259b2da63c632b4
https://doi.org/10.1038/s41591-021-01557-6
https://doi.org/10.1038/s41591-021-01557-6
Autor:
Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Robert H. Brown, Huaibin Cai, Zuoshang Xu
Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neuromuscular diseases. However, whether this modest elevation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8691bc0ce301b8ee5ae9e988561160e
https://doi.org/10.1101/2021.08.04.455119
https://doi.org/10.1101/2021.08.04.455119
Autor:
Michael A. Schwarzschild, Lina Song, Marc R. Freeman, Christian Mueller, Jake Metterville, Robert H. Brown, Alexandra Weiss, Owen M. Peters, Gaynor A. Smith, Robert Logan
Publikováno v:
Neurobiology of Disease, Vol 155, Iss, Pp 105368-(2021)
Neurobiol Dis
Neurobiol Dis
Parkinson's disease (PD) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. Though loss of dopaminergic neuron cell bodies from the substantia nigra pars compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1bf3d5b0857806cc0174236e01f592
http://www.sciencedirect.com/science/article/pii/S0969996121001170
http://www.sciencedirect.com/science/article/pii/S0969996121001170
Autor:
Ajit S. Puri, Helene Tran, Thomas Kenderdine, Robert Bowser, Dan Fabris, Huiya Yang, Catherine Douthwright, Robert M Brown, Jonathan K. Watts, Robert M. King, Alexandra Weiss, Jake Metterville, Heather L. Gray-Edwards, M Marosfoi, Michael P. Moazami, Diane McKenna-Yasek, Courtney Pinto, Minwook Shin, Craig Dooley, Nitasha Sanil, Nichols Wightman
Expansions of a G4C2 repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders. Proposed disease mechanisms include a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4669fa026cb2d1644bb2d30cdc512442
https://doi.org/10.21203/rs.3.rs-211236/v1
https://doi.org/10.21203/rs.3.rs-211236/v1
Autor:
Johnny Salameh, Alexandra Weiss, Owen M. Peters, Marc R. Freeman, Robert H. Brown, Elizabeth A. Lewis, Jeannette M. Osterloh, Jake Metterville
Publikováno v:
Human Molecular Genetics
Axon degeneration occurs in all neurodegenerative diseases, but the molecular pathways regulating axon destruction during neurodegeneration are poorly understood. Sterile Alpha and TIR Motif Containing 1 (Sarm1) is an essential component of the prode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cae1bb74060662b43e841e956ed8451
https://doi.org/10.1093/hmg/ddy260
https://doi.org/10.1093/hmg/ddy260