Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jake J Wen"'
Autor:
Jake J Wen, Nisha Jain Garg
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006687 (2018)
In this study, we have investigated the effects of manganese superoxide dismutase (SOD2 or MnSOD) deficiency on mitochondrial function and oxidative stress during Chagas disease. For this, C57BL/6 wild type (WT) and MnSOD+/- mice were infected with T
Externí odkaz:
https://doaj.org/article/54c2e14239c84c21ac4032440143b9e8
Autor:
Jianghua Tu, Yukimatsu Toh, Adela M. Aldana, Jake J. Wen, Ling Wu, Joan Jacob, Li Li, Sheng Pan, Kendra S. Carmon, Qingyun J. Liu
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 943 (2024)
Neuroblastoma (NB) is a cancer of the peripheral nervous system found in children under 15 years of age. It is the most frequently diagnosed cancer during infancy, accounting for ~12% of all cancer-related deaths in children. Leucine-rich repeat-cont
Externí odkaz:
https://doaj.org/article/b554555fbb0e479498a913ebf4b4a194
Publikováno v:
Journal of the American College of Surgeons. 236:783-802
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe5cf8f2c4cf9fff11756dbd0b7bd01
https://doi.org/10.1097/xcs.0000000000000546
https://doi.org/10.1097/xcs.0000000000000546
Autor:
Jake J Wen, Keyan Mobli, Victoria G Rontoyanni, Claire B Cummins, Geetha L Radhakrishnan, Andrew Murton, Ravi S Radhakrishnan
Publikováno v:
J Am Coll Surg
BACKGROUND: Our previous studies have found that burn injury induces cardiac dysfunction through interruption of the antioxidant-response-element (ARE) pathway in cardiac mitochondria. Nuclear factor erythroid 2–related factor 2 (Nrf2) is a key reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688edc192408653e4d93f878934bf9cc
https://pubmed.ncbi.nlm.nih.gov/35290286
https://pubmed.ncbi.nlm.nih.gov/35290286
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 566 (2020)
Burn-induced cardiac dysfunction is thought to involve mitochondrial dysfunction, although the mechanisms responsible are unclear. In this study, we used our established model of in vivo burn injury to understand the genetic evidence of burn-induced
Externí odkaz:
https://doaj.org/article/d8f215dcf245417b8809235875b1ff10
Publikováno v:
Journal of personalized medicine. 12(11)
In 2016, an estimated 486,000 individuals sustained burn injuries requiring medical attention. Severe burn injuries lead to a persistent, hyperinflammatory response that may last up to 2 years. The persistent release of inflammatory mediators contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cea1b9c4973c00261f911c0d5b7b2e
https://pubmed.ncbi.nlm.nih.gov/36579591
https://pubmed.ncbi.nlm.nih.gov/36579591
Autor:
Jake J. Wen, Ravi S. Radhakrishnan
The irreversible termination of individual life activities and metabolism means all fatal problems ultimately terminate the heart function. It’s very important to protect the patient’s life if we have treatment to maintain heart function and care
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5fd92adbcae8de7fe5df35cd139beb
https://mts.intechopen.com/articles/show/title/stress-induced-cardiomyopathy-1
https://mts.intechopen.com/articles/show/title/stress-induced-cardiomyopathy-1
Autor:
Geetha L. Radhakrishnan, Kayla M. Colvill, Jake J. Wen, Taylor P. Williams, Claire B. Cummins, Ravi S. Radhakrishnan
Publikováno v:
Journal of the American College of Surgeons. 232:642-655
Background Imbalance of oxidants/antioxidants results in heart failure, contributing to mortality after burn injury. Cardiac mitochondria are a prime source of reactive oxygen species (ROS), and a mitochondrial-specific antioxidant may improve burn-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa87479d1af7e7e108144c93c404fb2
https://doi.org/10.1016/j.jamcollsurg.2020.11.031
https://doi.org/10.1016/j.jamcollsurg.2020.11.031
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 6; Pages: 1007
Immune cascade is one of major factors leading to cardiac dysfunction after burn injury. TLRs are a class of pattern-recognition receptors (PRRs) that initiate the innate immune response by sensing conserved molecular patterns for early immune recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2010d435df532da6b91142e40e1dcb8b
Publikováno v:
Circulation Research. 129
Burn injury results in adverse myocardial remodeling and heart failure through circulatingcatecholamines and androgen and cytokine cascades. The DNA binding protein PARP1(poly ADP ribose polymerase 1) catalyzes a post translational modification to ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6729572fac6dbd5fb6e587b323a468a5
https://doi.org/10.1161/res.129.suppl_1.p370
https://doi.org/10.1161/res.129.suppl_1.p370