Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jake J Reske"'
Autor:
Jake J Reske, Mike R Wilson, Jeanne Holladay, Rebecca A Siwicki, Hilary Skalski, Shannon Harkins, Marie Adams, John I Risinger, Galen Hostetter, Ken Lin, Ronald L Chandler
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009986 (2021)
TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity rate. However, the functional relationship between TP53 and ARID1A mutations in the endometri
Externí odkaz:
https://doaj.org/article/50d23fb13fd7476982447aba9e632021
Autor:
Mike R. Wilson, Shannon Harkins, Jake J. Reske, Rebecca A. Siwicki, Marie Adams, Victoria L. Bae-Jump, Jose M. Teixeira, Ronald L. Chandler
Publikováno v:
Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Endometrial epithelia are known to harbor cancer driver mutations in the absence of any pathologies, including mutations in PIK3CA. Insulin plays an important role in regulating uterine metabolism during pregnancy, and hyperinsulinemia is as
Externí odkaz:
https://doaj.org/article/12fe81f9ee214cd59a993db686c57cab
Autor:
Mike R. Wilson, Hilary Skalski, Jake J. Reske, Marc Wegener, Marie Adams, Galen Hostetter, Hanne M. Hoffmann, Jamie J. Bernard, Victoria L. Bae-Jump, Jose M. Teixeira, Ronald L. Chandler
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are highly regulative of neighboring
Externí odkaz:
https://doaj.org/article/9315520ec7494ec88d336252345b051d
Autor:
Jake J. Reske, Mike R. Wilson, Brooke Armistead, Shannon Harkins, Cristina Perez, Joel Hrit, Marie Adams, Scott B. Rothbart, Stacey A. Missmer, Asgerally T. Fazleabas, Ronald L. Chandler
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-26 (2022)
Abstract Background SWI/SNF (BAF) chromatin remodeling complexes regulate lineage-specific enhancer activity by promoting accessibility for diverse DNA-binding factors and chromatin regulators. Additionally, they are known to modulate the function of
Externí odkaz:
https://doaj.org/article/ee04432bf9b94d2b8a24e167638717a0
Autor:
Ryan M. Marquardt, Soo Hyun Ahn, Jake J. Reske, Ronald L. Chandler, Margaret G. Petroff, Tae Hoon Kim, Jae-Wook Jeong
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6067 (2022)
A growing body of work suggests epigenetic dysregulation contributes to endometriosis pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich interaction domain 1A (ARID1A) must be properly expressed to maintain norma
Externí odkaz:
https://doaj.org/article/c2134e8a6aa5419ebbbc30573cffd9aa
Publikováno v:
Reproductive Sciences. 29:3266-3277
Endometriosis is a disease defined by the presence of abnormal endometrium at ectopic sites, causing pain and infertility in 10% of women. Mutations in the chromatin remodeling protein ARID1A (AT-rich interactive domain-containing protein 1A) have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a929d43717441808da7345450504b58
https://doi.org/10.1007/s43032-022-00974-3
https://doi.org/10.1007/s43032-022-00974-3
Autor:
Mike R. Wilson, Jake J. Reske, Julie Koeman, Marie Adams, Niraj R. Joshi, Asgerally T. Fazleabas, Ronald L. Chandler
Publikováno v:
Cells; Volume 11; Issue 6; Pages: 1000
Endometrial cancer (EC) is characterized by high estrogen levels unopposed by progesterone. Treatment with progestins is standard for early EC, but the response to progestins is dependent on progesterone receptor (PGR) expression. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1b56016e8ec0ceae56ca97904785b8
Autor:
Ronald L. Chandler, Marie Adams, Jeanne Holladay, Mike R. Wilson, Marc Wegener, Jake J. Reske
Publikováno v:
Hum Mol Genet
Although ARID1A mutations are a hallmark feature, mutations in other SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling subunits are also observed in endometrial neoplasms. Here, we interrogated the roles of Brahma/SWI2-related gene 1 (BRG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de70d0c6624c3aea2b0f914c297a44a
https://doi.org/10.1093/hmg/ddaa227
https://doi.org/10.1093/hmg/ddaa227
Autor:
Matti Kiupel, Hua Xiao, Jake J. Reske, Trevor G. Gohl, Devika Bahal, Rongcheng Luo, Daniel P. Hollern, Rupali Das, Yueqi Zhang, Xinhui Liu, Mark Williams, Elliot Ensink
Publikováno v:
Oncogene. 39:3821-3836
Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms underlying HCC development and identifying new prevention and therapeutic targets. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0374a3989e49112547dc927411d4fd5b
https://doi.org/10.1038/s41388-020-1256-x
https://doi.org/10.1038/s41388-020-1256-x
Autor:
Jake J. Reske, Mike R. Wilson, Brooke Armistead, Cristina Perez, Joel Hrit, Marie Adams, Scott B. Rothbart, Stacey A. Missmer, Asgerally T. Fazleabas, Ronald L. Chandler
ARID1A is a signature subunit of the mammalian SWI/SNF (BAF) chromatin remodeling complex and is mutated at a high rate in malignancies and benign diseases originating from the uterine endometrium. Through genome-wide analysis of human endometriotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fadbe458712fd8de0de802335422eba
https://doi.org/10.1101/2022.02.27.482165
https://doi.org/10.1101/2022.02.27.482165
