Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells

Autor: Jake Hsu, Nina Fatuzzo, Nielson Weng, Wojciech Michno, Wentao Dong, Maryline Kienle, Yuqin Dai, Anca Pasca, Monther Abu-Remaileh, Natalie Rasgon, Benedetta Bigio, Carla Nasca, Chaitan Khosla

Publikováno v: The Journal of biological chemistry.

In eukaryotes carnitine is best known for its ability to shuttle esterified fatty acids across mitochondrial membranes for β-oxidation. It also returns to the cytoplasm, in the form of acetyl-L-carnitine (LAC), some of the resulting acetyl groups fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cd7b69c27126f45775076bb193a4c2
https://pubmed.ncbi.nlm.nih.gov/36587768

Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase

Autor: Chaitan Khosla, Charles S. Craik, Natalia Sevillano, Florencia La Greca, Irimpan I. Mathews, Tsutomu Matsui, Xiuyuan Li, Jake Hsu

Publikováno v: Biochemistry, vol 57, iss 43

Assembly line polyketide synthases (PKSs) are large multimodular enzymes responsible for the biosynthesis of diverse antibiotics in bacteria. Structural and mechanistic analysis of these megasynthases can benefit from the discovery of reagents that r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9be25113e7814322738cde58cf29ddf
https://doi.org/10.1021/acs.biochem.8b00886

Evolution and Diversity of Assembly-Line Polyketide Synthases

Autor: Aleksandra, Nivina, Kai P, Yuet, Jake, Hsu, Chaitan, Khosla

Publikováno v: Chemical reviews. 119(24)

[Image: see text] Assembly-line polyketide synthases (PKSs) are among the most complex protein machineries known in nature, responsible for the biosynthesis of numerous compounds used in the clinic. Their present-day diversity is the result of an evo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fde27b975c7a4f47a079ec08b7102a5
https://pubmed.ncbi.nlm.nih.gov/31838842

'Marker of Self' CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors

Autor: Jake Hsu, Richard K. Tsai, Joe Swift, Irena I. Ivanovska, Dennis E. Discher, Nisha G. Sosale, Cory Alvey, Philip W. Zoltick

Publikováno v: Sosale, N G, Ivanovska, I, Tsai, R K, Swift, J, Hsu, J W, Alvey, C M, Zoltick, P W & Discher, D E 2016, ' "Marker of Self" CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors ', Molecular Therapy-Methods & Clinical Development . https://doi.org/10.1038/mtm.2016.80
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development

Lentiviruses infect many cell types and are now widely used for gene delivery in vitro, but in vivo uptake of these foreign vectors by macrophages is a limitation. Lentivectors are produced here from packaging cells that overexpress “Marker of Self

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deefb76771c9db6faae26cb3c80d0fca
https://doi.org/10.1038/mtm.2016.80

Angular 2 Cookbook : Discover Over 70 Recipes That Provide the Solutions You Need to Know to Face Every Challenge in Angular 2 Head on

Autor: Matthew Frisbie, Patrick Gillespie

Over 70 recipes to build applications with Angular 2Key Features[•] A first-rate reference guide with a clear structure and intuitive index that gives you as a developer exactly the information you want in exactly the way you want it[•] Covers no