Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jake E. Doiron"'
Autor:
Jake E. Doiron, Zhen Li, Xiaoman Yu, Kyle B. LaPenna, Heather Quiriarte, Timothy D. Allerton, Kashyap Koul, Andrew Malek, Sanjiv J. Shah, Thomas E. Sharp, Traci T. Goodchild, Daniel R. Kapusta, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 4 (2024)
Background The renal sympathetic nervous system modulates systemic blood pressure, cardiac performance, and renal function. Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejec
Externí odkaz:
https://doaj.org/article/377b6dd424934dd9a1525c1d2e497cee
Autor:
Axel J. Fenwick, Vivek P. Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle LaPenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass, Anthony Cammarato
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/a084e9b1e94b4c3c8eb42688403bb233
Autor:
Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
Background Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction (
Externí odkaz:
https://doaj.org/article/7aac073711094e04ba91e3ff73aa8fb6
Autor:
Kyle B. LaPenna, David J. Polhemus, Jake E. Doiron, Hunter A. Hidalgo, Zhen Li, David J. Lefer
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 485 (2021)
Hydrogen sulfide (H2S) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. H2S regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent st
Externí odkaz:
https://doaj.org/article/d04350a08e2e4f3690b8fb9332a7acc7
Autor:
Jake E. Doiron, Kyle Lapenna, Zhen Li, Huijing Xia, Traci Goodchild, Ming Xian, Jianming Kang, David Lefer
Publikováno v:
The FASEB Journal. 36
Autor:
Kyle B. LaPenna, Zhen Li, Thomas E. Sharp, Karl H. Mose, Jake E. Doiron, Huijing Xia, Traci T. Goodchild, David J. Lefer
Publikováno v:
The FASEB Journal. 36
Autor:
Kenneth L. Martin, Mark Turlington, Jake E. Doiron, Stephen G. Aller, Gary W. Breton, John Bacsa, Christina A. Le
Publikováno v:
ChemMedChem. 15:1720-1730
Although the 1,2,3-triazole is a commonly used amide bioisostere in medicinal chemistry, the structural implications of this replacement have not been fully studied. Employing X-ray crystallography and computational studies, we report the spatial and
Autor:
Savannah J. Post, Liping Tang, Matthew J. Mulder, Christina A. Le, Mark Turlington, Stephen G. Aller, Steven M. Rowe, Gary W. Breton, Sichen Chang, Britton K. Ody, Jonathon B. Brace, Jake E. Doiron, Harrison M. Hill, Wei Wang, Nathan L. Thacker, Thomas M. Bridges
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(14)
The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this precedent, triazole analogues derived from VX-809 and VX-770, prominent amide-containing modulators of the cystic fibrosis trans