Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jake E. Batchelder"'
Autor:
Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in
Externí odkaz:
https://doaj.org/article/eab356ebc3d24e3c88297e4fc7fbc176
Autor:
Varsha Prakash, Brittany B. Carson, Jennifer M. Feenstra, Randall A. Dass, Petra Sekyrova, Ayuko Hoshino, Julian Petersen, Yuan Guo, Matthew M. Parks, Chad M. Kurylo, Jake E. Batchelder, Kristian Haller, Ayako Hashimoto, Helene Rundqivst, John S. Condeelis, C. David Allis, Denis Drygin, M. Angela Nieto, Michael Andäng, Piergiorgio Percipalle, Jonas Bergh, Igor Adameyko, Ann-Kristin Östlund Farrants, Johan Hartman, David Lyden, Kristian Pietras, Scott C. Blanchard, C. Theresa Vincent
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Ribosomal DNA transcription is essential for cell growth and division. Here, the authors show that EMT is accompanied by Snail binding to rDNA operons and Rictor association with nucleoli to fuel an induction of ribosome biogenesis during G1/S cell c
Externí odkaz:
https://doaj.org/article/d55a3dcbab384f5da902c83d1a827b47
Autor:
Siquan Chen, Asif Zubair, Ravi C. Kalathur, M. Madan Babu, Jon P. Connelly, Darcie J. Miller, Kaley Blankenship, Min Pan, Michael A. Dyer, Jake E. Batchelder, Shondra M. Pruett-Miller, Brandt C. Huddle, Matthew J. Posgai, Scott C. Blanchard, William C. Wright, Richard H. Chapple, Samuel W. Brady, Sivaraman Natarajan, Payton Archer, John Easton, Elizabeth Stewart, Paul Geeleher, Jonathan Low, Lucy A. Godley, John D. Schuetz, Taosheng Chen, Manbir Sandhu, Burgess B. Freeman, Yingzhe Wang, Brittney Gordon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Survival in high-risk pediatric neuroblastoma has remained around 50% for the last 20 years, with immunotherapies and targeted therapies having had minimal impact. Here, we identify the small molecule CX-5461 as selectively cytotoxic to high-risk neu
Publikováno v:
Chromosome Research
The evolution of the multi-copy family of ribosomal RNA (rRNA) genes is unique in regard to its genetics and genome evolution. Paradoxically, rRNA genes are highly homogenized within and between individuals, yet they are globally distinct between spe
Autor:
Jake E. Batchelder, Scott C. Blanchard, Alessandro Borgia, Ouissam El Bakouri, Steffen Jockusch, Wesley B. Asher, Brandt C. Huddle, Gabriel A. Fitzgerald, Avik Kumar Pati, Michael D. Holsey, Jonathan A. Javitch, Henrik Ottosson, Chathura Abeywickrama, Dominic A. Rufa, Roger B. Altman, Zhou Zhou, Daniel S. Terry
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fluorescence imaging, a central pillar of medical and fundamental research, is hampered by stochastic blinking, limited photon budgets, and phototoxicities of organic fluorophores. Here, we use quantum chemical calculations and targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7597c08b84b206c22f71334225b33c
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423464
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423464
Autor:
Garry P. Nolan, Amanda R. Groziak, Wendy J. Fantl, Jake E. Batchelder, Andreas P. Frei, Felice Alessio Bava, Samuel C. Kimmey, Yuki Yoshiyasu, Pier Federico Gherardini, Julie M. Yu, Tyler J. Burns, Veronica D. Gonzalez
Publikováno v:
Cytometry Part A. 91:180-189
To quantify visual and spatial information in single cells with a throughput of thousands of cells per second, we developed Subcellular Localization Assay (SLA). This adaptation of Proximity Ligation Assay expands the capabilities of flow cytometry t
Autor:
Helene Rundqivst, Piergiorgio Percipalle, Jonas Bergh, Chad M. Kurylo, John S. Condeelis, Kristian Haller, C. David Allis, Ayuko Hoshino, David Lyden, Julian Petersen, Varsha Prakash, M. Angela Nieto, Scott C. Blanchard, Randall A. Dass, Ayako Hashimoto, Jake E. Batchelder, Johan Hartman, Brittany Carson, Petra Sekyrova, Ann-Kristin Östlund Farrants, Kristian Pietras, C. Theresa Vincent, Igor Adameyko, Matthew Parks, Jennifer M. Feenstra, Michael Andäng, Yuan Guo, Denis Drygin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f6dc5bb4df85ea5f83e8f1b8b175a9
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-384067
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-384067
Publikováno v:
Chromosome Research. 27:285-285
The article Implications of sequence variation on the evolution of rRNA, written by Matthew M. Parks, Chad M. Kurylo, Jake E. Batchelder, C. Theresa Vincent and Scott C. Blanchard, was originally published electronically on the publisher’s internet