Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jake D Lehle"'
Publikováno v:
eLife, Vol 13 (2024)
Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic compounds that can disrupt endocrine signaling due to steric similarities to endogenous hormones. EDCs have been shown to induce disruptions in normal epigenetic programmi
Externí odkaz:
https://doaj.org/article/a107967b518c48938b0178a04dc584dc
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168038 (2016)
Exposure to environmental factors can induce the epigenetic transgenerational inheritance of disease. Alterations to the epigenome termed "epimutations" include "primary epimutations" which are epigenetic alterations in the absence of genetic change
Externí odkaz:
https://doaj.org/article/5d8d66db1ddd4616b8d0820b66165faf
Autor:
Jake D. Lehle, John R. McCarrey
Background Analyzing whole-genome bisulfite sequencing (WGBS) datasets is a time-intensive process due to the complexity and size of the input raw sequencing files and lengthy read alignment step during downstream data processing. This is particularl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ac91f19e9ec526e6945bb12e127fd9
https://doi.org/10.21203/rs.3.rs-1666741/v1
https://doi.org/10.21203/rs.3.rs-1666741/v1
Autor:
John R. McCarrey, Jake D. Lehle
Publikováno v:
Environmental Epigenetics
There is now considerable evidence indicating the potential for endocrine disrupting chemicals to alter the epigenome and for subsets of these epigenomic changes or “epimutations” to be heritably transmitted to offspring in subsequent generations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c016ea7cbd32ce93b5c1564fd785a783
https://doi.org/10.1093/eep/dvaa016
https://doi.org/10.1093/eep/dvaa016
Autor:
Danielle Fritze, Sherman J. Silber, Brian P. Hermann, Anukriti Singh, John R. McCarrey, Jake D. Lehle, Nathan C. Law, Christopher B. Geyer, Kazadi N. Mutoji, Heidi Gildersleeve, Jon M. Oatley, Bryan A. Niedenberger, Melissa J. Oatley, Birgit Westernströer, Keren Cheng, I-Chung Chen, Ellen K. Velte, Max Mayo, Lorena Roa‑de La Cruz
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1650-1667.e8 (2018)
Summary: Spermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene expression have been described for aggregates of certain spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902da2a9bb05726a96f6188968126165
http://www.sciencedirect.com/science/article/pii/S2211124718316024
http://www.sciencedirect.com/science/article/pii/S2211124718316024
Autor:
Eric E. Nilsson, Yufeng Wang, John R. McCarrey, Michael K. Skinner, Seetha S. Raju, Jake D. Lehle
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168038 (2016)
PLoS ONE
PLoS ONE
Exposure to environmental factors can induce the epigenetic transgenerational inheritance of disease. Alterations to the epigenome termed “epimutations” include “primary epimutations” which are epigenetic alterations in the absence of genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5ad10b3f9ea85b6df823c308392969
http://europepmc.org/articles/PMC5167269?pdf=render
http://europepmc.org/articles/PMC5167269?pdf=render
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Retention of source cell-type epigenetic memory may mitigate the potential for induced pluripotent stem cells (iPSCs) to fully achieve transitions in cell fate in vitro. While this may not preclude the use of iPSC-derived somatic cell t
Externí odkaz:
https://doaj.org/article/95a70dfc1deb444abb498ee83e03553a
Autor:
Brian P. Hermann, Keren Cheng, Anukriti Singh, Lorena Roa-De La Cruz, Kazadi N. Mutoji, I-Chung Chen, Heidi Gildersleeve, Jake D. Lehle, Max Mayo, Birgit Westernströer, Nathan C. Law, Melissa J. Oatley, Ellen K. Velte, Bryan A. Niedenberger, Danielle Fritze, Sherman Silber, Christopher B. Geyer, Jon M. Oatley, John R. McCarrey
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1650-1667.e8 (2018)
Summary: Spermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene expression have been described for aggregates of certain spe
Externí odkaz:
https://doaj.org/article/63630473e8244b48803a81b255bb4001