Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jake Brooks"'
Autor:
Jake Brooks, James Everett, Emily Hill, Kharmen Billimoria, Christopher M. Morris, Peter J. Sadler, Neil Telling, Joanna F. Collingwood
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract Neuromelanin-pigmented neurons of the substantia nigra are selectively lost during the progression of Parkinson’s disease. These neurons accumulate iron in the disease state, and iron-mediated neuron damage is implicated in cell death. Ani
Externí odkaz:
https://doaj.org/article/63afa146f787477b8ee42d09a8905646
Autor:
Anne-Claire Jacomin, Kalotina Geraki, Jake Brooks, Vindy Tjendana-Tjhin, Joanna F. Collingwood, Ioannis P. Nezis
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Biometals such as iron, copper, potassium, and zinc are essential regulatory elements of several biological processes. The homeostasis of biometals is often affected in age-related pathologies. Notably, impaired iron metabolism has been linked to sev
Externí odkaz:
https://doaj.org/article/7392bc740420419497fc1622152c6f83
Autor:
Frederik Lermyte, James Everett, Jake Brooks, Francesca Bellingeri, Kharmen Billimoria, Peter J. Sadler, Peter B. O’Connor, Neil D. Telling, Joanna F. Collingwood
Publikováno v:
Cells, Vol 8, Iss 10, p 1231 (2019)
Transition metals have essential roles in brain structure and function, and are associated with pathological processes in neurodegenerative disorders classed as proteinopathies. Synchrotron X-ray techniques, coupled with ultrahigh-resolution mass spe
Externí odkaz:
https://doaj.org/article/6debd0ab7b2c4aa28856e8856588633c
Autor:
Peter J. Sadler, Jon Dobson, Jake Brooks, Peter B. O’Connor, Frederik Lermyte, Neil D. Telling, Joanna F. Collingwood, James Everett
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Atypical low-oxidation-state iron phases in Alzheimer’s disease (AD) pathology are implicated in disease pathogenesis, as they may promote elevated redox activity and convey toxicity. However, the origin of low-oxidation-state iron and the pathways
Autor:
Jake Brooks
Publikováno v:
Proceedings of the Microscience Microscopy Congress 2021 incorporating EMAG 2021.
Autor:
Kharmen Billimoria, James Everett, Xiongwei Zhu, Peter B. O’Connor, Ian Hands-Portman, Germán Plascencia-Villa, Vindy Tjendana-Tjhin, Neil D. Telling, Jake Brooks, Frederik Lermyte, George Perry, Joanna F. Collingwood, Jane M. Donnelly, Peter J. Sadler
Publikováno v:
Science Advances
Discovery of nanometallic Cu0 with Fe0 in the human brain will fundamentally boost our understanding of neurobiology.
The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing p
The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec26e6dbe13e7ed07dc07621a23e0fb6
https://eprints.keele.ac.uk/9774/1/eabf6707.full.pdf
https://eprints.keele.ac.uk/9774/1/eabf6707.full.pdf
Autor:
Frederik Lermyte, Peter B. O’Connor, Peter J. Sadler, Joanna F. Collingwood, Mark P. Barrow, Jake Brooks, Neil D. Telling, Yuko P. Y. Lam, Christopher A. Wootton, James Everett
Publikováno v:
Journal of the American Society for Mass Spectrometry
Native top-down mass spectrometry is a fast, robust biophysical technique that can provide molecular-scale information on the interaction between proteins or peptides and ligands, including metal cations. Here we have analyzed complexes of the full-l
Iron (Fe) is an essential trace element required for healthy brain function. Yet, disrupted iron neurochemistry, and the associated formation of aberrantly aggregated protein lesions has been implicated in the development of multiple degenerative bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d1a83b78ed898fe6e1bc1704ec847d
Autor:
Frederik Lermyte, Peter J. Sadler, Christopher Morris, Peter B. O’Connor, Neil D. Telling, James Everett, Vindy Tjendana Tjhin, Jake Brooks, Samya Banerjee, Joanna F. Collingwood
Publikováno v:
Angewandte Chemie (International Ed. in English)
A hallmark of Parkinson's disease is the death of neuromelanin‐pigmented neurons, but the role of neuromelanin is unclear. The in situ characterization of neuromelanin remains dependent on detectable pigmentation, rather than direct quantification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3a19b7190bc4fc99affb1ffa1e3cb6
https://eprints.keele.ac.uk/8229/1/anie.202000239.pdf
https://eprints.keele.ac.uk/8229/1/anie.202000239.pdf
Autor:
Frederik Lermyte, Margaret P. Rayman, Peter J. Sadler, Martin R. Lees, Joanna F. Collingwood, Steven Huband, Wen-Ying Zhang, Jake Brooks
Publikováno v:
Foodfunction. 11(4)
Iron is an essential element, and cornflake-style cereals are typically fortified with iron to a level up to 14 mg iron per 100 g. Even single cornflakes exhibit magnetic behaviour. We extracted iron microparticles from samples of two own-brand super