Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jake A Kushner"'
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0214829 (2019)
Tamoxifen is a mixed agonist/antagonist estrogen analogue that is frequently used to induce conditional gene deletion in mice using Cre-loxP mediated gene recombination. Tamoxifen is routinely employed in extremely high-doses relative to typical huma
Externí odkaz:
https://doaj.org/article/add5045f70bc482788ab2d59d78b525a
Autor:
Rahul Pandey, Marina Bakay, Heather S Hain, Bryan Strenkowski, Barakat Z B Elsaqa, Jeffrey D Roizen, Jake A Kushner, Jordan S Orange, Hakon Hakonarson
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203952 (2018)
CLEC16A is implicated in multiple autoimmune diseases. We generated Clec16a inducible knockout (KO) mice to examine the functional link between CLEC16A auto-inflammation and autoimmunity. Clec16a KO mice exhibited weight loss and thymic and splenic a
Externí odkaz:
https://doaj.org/article/563c11486a71460587c4bdf84af47c84
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206102 (2018)
AIMS:Adolescent girls with diabetes are at risk for adverse pregnancy outcomes due to age, risk-taking behavior, poor glycemic control, and lack of knowledge. Our aims were to assess attitudes and behaviors related to reproductive health education (R
Externí odkaz:
https://doaj.org/article/e99079463ff84535b9b932ac15567930
Autor:
Aaron R Cox, Ornella Barrandon, Erica P Cai, Jacqueline S Rios, Julia Chavez, Claire W Bonnyman, Carol J Lam, Peng Yi, Douglas A Melton, Jake A Kushner
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159276 (2016)
The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced a 17-fold increase in β-cell proliferation. Subsequent studies in mice contested this cla
Externí odkaz:
https://doaj.org/article/b0c7a710f65845308d7de3b10b76ee2f
Autor:
Emily J Shields, Carol J Lam, Aaron R Cox, Matthew M Rankin, Thomas J Van Winkle, Rebecka S Hess, Jake A Kushner
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129809 (2015)
The pathophysiology of canine diabetes remains poorly understood, in part due to enigmatic clinical features and the lack of detailed histopathology studies. Canine diabetes, similar to human type 1 diabetes, is frequently associated with diabetic ke
Externí odkaz:
https://doaj.org/article/5215cc7f5f194ca0b8537dd6afdb0851
Autor:
Jennifer L. Trainor, Nicole S. Glaser, Leah Tzimenatos, Michael J. Stoner, Kathleen M. Brown, Julie K. McManemy, Jeffrey E. Schunk, Kimberly S. Quayle, Lise E. Nigrovic, Arleta Rewers, Sage R. Myers, Jonathan E. Bennett, Maria Y. Kwok, Cody S. Olsen, T. Charles Casper, Simona Ghetti, Nathan Kuppermann, Clinton S. Perry, James P. Marcin, Mary Murray, Jared Henricksen, Brad Poss, J. Michael Dean, Bema Bonsu, Tensing Maa, Justin Indyk, Marian Rewers, Peter Mourani, Jake A. Kushner, Laura L. Loftis, Monika Goyal, Rakesh Mistry, Vijay Srinivasan, Andrew Palladino, Colin Hawkes, Joseph I. Wolfsdorf, Michael S. Agus, Linda Snelling, Charlotte Boney, Fran R. Cogen, Sonali Basu, Neil H. White, Nikoleta S. Kolovos, Donald Zimmerman, Denise Goodman, Andrew D. DePiero, Daniel A. Doyle, Meg A. Frizzola, Scott Baird, David Schnadower
Publikováno v:
Annals of Emergency Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6625476bb40a7aa82edecc5508fd4d88
https://doi.org/10.1016/j.annemergmed.2023.01.001
https://doi.org/10.1016/j.annemergmed.2023.01.001
Autor:
Wenjun Jiang, Jake A. Kushner, Michael J Davies, Helena W. Rodbard, Pablo Lapuerta, Ketan Dhatariya, Anne L. Peters, Phillip Banks, Darren K. McGuire, Sangeeta Sawhney, Thomas Danne
Publikováno v:
Diabetes Care
OBJECTIVE To evaluate the incidence and risk factors for diabetic ketoacidosis (DKA) and related adverse events (AEs) in adults with type 1 diabetes treated with sotagliflozin adjunctive to insulin. RESEARCH DESIGN AND METHODS Data from two identical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1307dedc63a32d96131b84cbcb4384f7
https://doi.org/10.2337/dc20-0924
https://doi.org/10.2337/dc20-0924
Autor:
Darren K. McGuire, Mark O'Neill, Frank Mikell, Anne L. Peters, Claire Baker, Phillip Banks, Diane Gesty‐Palmer, Suman Wason, Thomas Danne, Sangeeta Sawhney, Paul Strumph, Anna Chang, Jake A. Kushner
Publikováno v:
Diabetes, Obesity & Metabolism
Aims To assess the dose‐related effects of sotagliflozin, a novel dual inhibitor of sodium‐glucose co‐transporters‐1 and ‐2, in type 1 diabetes (T1D). Materials and methods In this 12‐week, multicentre, randomized, double‐blind, placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e569d763c211bd8fce1076a7a1ad43ea
https://doi.org/10.1111/dom.13825
https://doi.org/10.1111/dom.13825
Publikováno v:
Diabetes, Obesity & Metabolism
Aims The global rate of type 2 diabetes (T2D) continues to rise. Guidelines that influence the worldwide treatment of this disease are central to changing this trajectory. We sought in this review to evaluate the appropriateness of sources cited in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c806f1e9b2b70f5bf5a4e8860305dce
http://europepmc.org/articles/PMC6767093
http://europepmc.org/articles/PMC6767093
Autor:
Carol J. Lam, Matthew M. Rankin, Jake A. Kushner, Brian Christopher Shook, Kourtney B King, Melinda C Wang
Publikováno v:
Diabetes
Glucagon-containing α-cells potently regulate glucose homeostasis, but the developmental biology of α-cells in adults remains poorly understood. Although glucagon receptor antagonists (GRAs) have great potential as antidiabetic therapies, murine an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8d0391bd0cc8130faecd2555ad8062
https://doi.org/10.2337/db18-1293
https://doi.org/10.2337/db18-1293