Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Jake, Baum"'
Autor:
Dihia Moussaoui, James P. Robblee, Julien Robert-Paganin, Daniel Auguin, Fabio Fisher, Patricia M. Fagnant, Jill E. Macfarlane, Julia Schaletzky, Eddie Wehri, Christoph Mueller-Dieckmann, Jake Baum, Kathleen M. Trybus, Anne Houdusse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including different antimalarial combinations. The class XIV myosin motor PfMyoA is part of a cor
Externí odkaz:
https://doaj.org/article/649b74fa0af0445585a6975102ee7c70
Autor:
Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith AM Scholz, Helle Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael F Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington, Anna Bachmann
Publikováno v:
eLife, Vol 12 (2024)
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorp
Externí odkaz:
https://doaj.org/article/ee63f3338efa4b578bd3c5c0608fd5e0
Autor:
Kenny Malpartida-Cardenas, Nicolas Moser, Felix Ansah, Ivana Pennisi, Diana Ahu Prah, Linda Eva Amoah, Gordon Awandare, Julius Clemence R. Hafalla, Aubrey Cunnington, Jake Baum, Jesus Rodriguez-Manzano, Pantelis Georgiou
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Human malaria is a life-threatening parasitic disease with high impact in the sub-Saharan Africa region, where 95% of global cases occurred in 2021. While most malaria diagnostic tools are focused on Plasmodium falciparum, there is a current
Externí odkaz:
https://doaj.org/article/766dd66afdd8473d9425ec0842b6bdc0
Autor:
Jem Murdoch, Jake Baum
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp n/a-n/a (2023)
Malaria remains a huge burden on global public health. Annually there are more than 200 million cases with > 600,000 deaths worldwide, the vast majority of which occur within Sub‐Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is
Externí odkaz:
https://doaj.org/article/63a817ff22644578afe66fed0ef4ee9f
Autor:
Sabrina Yahiya, Charlie N. Saunders, Sarah Hassan, Ursula Straschil, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J. Delves, Edward W. Tate, Anna Barnard, Matthew J. Fuchter, Jake Baum
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/537be52acb9d42a7a54013ab74d8c046
Autor:
Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M. J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito
Externí odkaz:
https://doaj.org/article/5a569da9aa694e86aa5e04aa0c21ba75
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The multi-subunit chaperonin containing TCP-1 (CCT) is an essential molecular chaperone that functions in the folding of key cellular proteins. This paper reviews the interactome of the eukaryotic chaperonin CCT and its primary clients, the ubiquitou
Externí odkaz:
https://doaj.org/article/519e1cecb56344f58289487b9fbae055
Autor:
Eliana Real, Virginia M. Howick, Farah A. Dahalan, Kathrin Witmer, Juliana Cudini, Clare Andradi-Brown, Joshua Blight, Mira S. Davidson, Sunil Kumar Dogga, Adam J. Reid, Jake Baum, Mara K. N. Lawniczak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here the authors use single-cell RNA-seq to profile the transmission stages of the human malaria parasite Plasmodium falciparum as it progresses through the Anopheles mosquito. They highlight unique patterns of gene usage throughout this development
Externí odkaz:
https://doaj.org/article/d794f8b7a61a40a4b465c503752b3e54
Autor:
Celia Miguel-Blanco, James M. Murithi, Ernest Diez Benavente, Fiona Angrisano, Katarzyna A. Sala, Donelly A. van Schalkwyk, Manu Vanaerschot, Frank Schwach, Matthew J. Fuchter, Oliver Billker, Colin J. Sutherland, Susana G. Campino, Taane G. Clark, Andrew M. Blagborough, David A. Fidock, Esperanza Herreros, Francisco Javier Gamo, Jake Baum, Michael J. Delves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract New antimalarial therapeutics are needed to ensure that malaria cases continue to be driven down, as both emerging parasite resistance to frontline chemotherapies and mosquito resistance to current insecticides threaten control programmes. P
Externí odkaz:
https://doaj.org/article/900b4a91fa834a71a9fd17eeaf2b6009
Autor:
Sabrina Yahiya, Sarah Jordan, Holly X Smith, David C A Gaboriau, Mufuliat T Famodimu, Farah A Dahalan, Alisje Churchyard, George W Ashdown, Jake Baum
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010276 (2022)
Formation of gametes in the malaria parasite occurs in the midgut of the mosquito and is critical to onward parasite transmission. Transformation of the male gametocyte into microgametes, called microgametogenesis, is an explosive cellular event and
Externí odkaz:
https://doaj.org/article/1515374a49094d58be725d3231734c25