Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jaka Marušič"'
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Development of novel therapeutic proteins and biosimilars requires a thorough understanding of the relationship between their structure and function. Particularly, how IgG glycosylation affects its effector functions is a point increasingly underscor
Externí odkaz:
https://doaj.org/article/6c057d7513b44d1cb450e73700405754
Autor:
Katja, Glinšek, Lovro, Kramer, Aleksander, Krajnc, Eva, Kranjc, Nina, Pirher, Jaka, Marušič, Leon, Hellmann, Barbara, Podobnik, Borut, Štrukelj, David, Ausländer, Rok, Gaber
Publikováno v:
Biotechnology Journal. 17:2100499
Difficulties in obtaining and maintaining the desired level of the critical quality attributes (CQAs) of therapeutic proteins as well as the pace of the development are major challenges of current biopharmaceutical development. Therapeutic proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0827947dcd6b168365f1a153407e6a56
https://doi.org/10.1002/biot.202100499
https://doi.org/10.1002/biot.202100499
Publikováno v:
Scientific Reports
Biosimilar drug products must have a demonstrated similarity with respect to the reference product’s molecules in order to ensure both the effectiveness of the drug and the patients’ safety. In this paper the fusion framework of a highly sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bc649c04c3730e92d23143c10ef5e1
Publikováno v:
Journal of Biological Chemistry. 287:8613-8620
Human tumor necrosis factor α (TNF-α) exists in its functional state as a homotrimeric protein and is involved in inflammation processes and immune response of a human organism. Overproduction of TNF-α results in the development of chronic autoimm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed63b07260add1d090a1deade89c7c39
https://doi.org/10.1074/jbc.m111.318451
https://doi.org/10.1074/jbc.m111.318451