Zobrazeno 1 - 10
of 2 598
pro vyhledávání: '"Jak2/Stat3"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Background Existing studies have already revealed the involvement of C–C chemokine receptor type 7 (CCR7) in diverse human cancers, including esophageal cell squamous carcinoma (ESCA). Our current study, aims to explore the relevant mechan
Externí odkaz:
https://doaj.org/article/d97d2de964894022a93522b37906ba63
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract To explore the effects and mechanisms of the Xianhecao-Huanglian drug pair on autophagy-mediated intervention in acute inflammatory bowel disease (IBD) via the JAK2/STAT3 pathway. The study examined the underlying mechanisms of action of Xia
Externí odkaz:
https://doaj.org/article/7ce71fc06adf48a4bacccbd27eea4dff
Autor:
Suqin Yang, Jingtao Huang, Wenjing Tan, Xiankun Xia, Dali Gan, Yalei Ren, Hanwen Su, Meixian Xiang
Publikováno v:
Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Xiaoyankangjun tablet (XYKJP) is a traditional Chinese medicine formulation used to treat intestinal disorders in clinical practice. However, the specific therapeutic mechanism of action of XYKJP in colitis has not yet been elucidated. This
Externí odkaz:
https://doaj.org/article/da0191f6e9d546488ee7085461eac475
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Purpose Exosomal microRNAs have been identified as important mediators of communication between tumor cells and macrophages in the microenvironment. miR-541-5p was reported to be involved in hepatocellular carcinoma progression, but its role
Externí odkaz:
https://doaj.org/article/3ca587e6f2d243faa515b09fec7aeea4
Autor:
Tong-Tong Liu, Hai-Fei Sun, Ming-Ze Tang, Hao-Ran Shen, Zhen Shen, Yan-Xing Han, Yun Zhan, Jian-Dong Jiang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Silicosis is an irreversible fibrotic disease of the lung caused by chronic exposure to silica dust, which manifests as infiltration of inflammatory cells, excessive secretion of pro-inflammatory cytokines, and pulmonary diffuse f
Externí odkaz:
https://doaj.org/article/2b118b10efc04e819d2449e7e07a98e0
Autor:
Fengxia CHEN, Feifei PU
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 7, Pp 554-560 (2024)
ObjectiveTo investigate the effect of folic acid–modified liposome quercetin (FLQ) on the proliferation and apoptosis of triple negative breast cancer (TNBC) cells and explore its underlying mechanism. MethodsCCK-8 was used to detect the effect of
Externí odkaz:
https://doaj.org/article/68e92d828f4446f4a3477baf0e8b046a
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-8 (2024)
Abstract Purpose Oncostatin M (OSM) is involved in the regulation of osteogenic differentiation and has a major role in the development of heterotopic ossification. The role of OSM in osteogenic differentiation of tendon-derived stem cells (TDSCs) an
Externí odkaz:
https://doaj.org/article/6fe7cf4cfe744cb08723133dd042cf7a
Autor:
Jianxian Xiong, Jiayuan Ling, Jie Yan, Yanyu Duan, Junjian Yu, Wentong Li, Wenbo Yu, Jianfeng Gao, Dilin Xie, Ziyou Liu, Yongzhi Deng, Yongling Liao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Aortic dissection (AD) is a life-threatening condition with a high mortality rate and without effective pharmacological therapies. Our previous study illustrated that leukocyte immunoglobulin-like receptor B4 (LILRB4) knockdown promoted the
Externí odkaz:
https://doaj.org/article/e6e1ef1473a24cf9a5352a0a58d49b36
Autor:
Zhao-Da Duan, Li-Yang Zheng, Qiu-Ye Jia, Hao-Lun Chen, Dong-Yao Xu, Yu-Jia Yang, Zhi Qi, Li Yang, Chun-Yun Wu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Previous studies have shown that scutellarin inhibits the excessive activation of microglia, reduces neuronal apoptosis, and exerts neuroprotective effects. However, whether scutellarin regulates activated microglia-mediated neuronal apoptos
Externí odkaz:
https://doaj.org/article/484392d96b504a778b3704c4266659c9
Autor:
Do Manh Cuong, Sun Hee Yang, Ji Soo Kim, Jeong Yong Moon, Jongkeun Choi, Gyung Min Go, Somi Kim Cho
Publikováno v:
Applied Biological Chemistry, Vol 67, Iss 1, Pp 1-15 (2024)
Abstract Increased production of reactive oxygen species (ROS) leads to oxidative stress, with its damaging effect extending to the mitochondria and plasma membrane. Further, prolonged inflammation can result in chronic disease development. The marin
Externí odkaz:
https://doaj.org/article/b6db9d5411de4e278b33510cff7f44bf