Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jak Grimes"'
Autor:
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O’Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of β1-adrenoceptors, ar
Externí odkaz:
https://doaj.org/article/31913551d70443ecbc6be0521f89476a
Autor:
Jak Grimes, Sapna Desai, Neil W. Charter, James Lodge, Rita Moita Santos, Albert Isidro‐Llobet, Andrew M. Mason, Zining Wu, Lawrence A. Wolfe III, Lakshmi Anantharaman, Andrew Green, Angela M. Bridges, Deidre A. Dalmas Wilk, Andrew J. Brown
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Activation of MrgX2, an orphan G protein‐coupled receptor expressed on mast cells, leads to degranulation and histamine release. Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic p
Externí odkaz:
https://doaj.org/article/d52477c4710a45b380964101c0429cd7
Publikováno v:
Entropy, Vol 23, Iss 8, p 1044 (2021)
In this article, we introduce a new method to detect transient trapping events within a single particle trajectory, thus allowing the explicit accounting of changes in the particle’s dynamics over time. Our method is based on new measures of a smoo
Externí odkaz:
https://doaj.org/article/8b4c9e392b7b4054839df5acb6aa5a84
Autor:
Teresa Buenaventura, Stavroula Bitsi, William E Laughlin, Thomas Burgoyne, Zekun Lyu, Affiong I Oqua, Hannah Norman, Emma R McGlone, Andrey S Klymchenko, Ivan R Corrêa, Abigail Walker, Asuka Inoue, Aylin Hanyaloglu, Jak Grimes, Zsombor Koszegi, Davide Calebiro, Guy A Rutter, Stephen R Bloom, Ben Jones, Alejandra Tomas
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000097 (2019)
The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of th
Externí odkaz:
https://doaj.org/article/8615184b004840e48897e4b6bd2088e9
Publikováno v:
GPCRs as Therapeutic Targets. :946-977
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176abc840e0581c39e90bdb924bbde8c
https://doi.org/10.1002/9781119564782.ch26
https://doi.org/10.1002/9781119564782.ch26
Autor:
Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Tamara Miljus, Shannon L. O’Brien, Tomasz M. Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Ravi Mistry, Joëlle Goulding, Julia Drube, Carsten Hoffmann, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro
Publikováno v:
Cell
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df63d5d439e67b15630e00bb403cf9c
https://europepmc.org/articles/PMC7614532/
https://europepmc.org/articles/PMC7614532/
Autor:
Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Tamara Miljus, Shannon L. O’Brien, Tomasz M Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro
SUMMARYβ-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor–β-arrestin interactions at the plasma membrane of living cells remain e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38f96ef53e7d5824aea2949dbeef178f
https://doi.org/10.1101/2022.11.15.516577
https://doi.org/10.1101/2022.11.15.516577
Publikováno v:
Entropy
Volume 23
Issue 8
Entropy, Vol 23, Iss 1044, p 1044 (2021)
Volume 23
Issue 8
Entropy, Vol 23, Iss 1044, p 1044 (2021)
In this article, we introduce a new method to detect transient trapping events within a single particle trajectory, thus allowing the explicit accounting of changes in the particle’s dynamics over time. Our method is based on new measures of a smoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43785c985d76920d1b5bc0d7c002f07
Autor:
Jak Grimes, Davide Calebiro
Publikováno v:
Annual review of pharmacology and toxicology. 60
G protein–coupled receptors (GPCRs) mediate the effects of numerous hormones and neurotransmitters and are major pharmacological targets. Classical studies with crude cell lysates or membrane preparations have identified the main biochemical steps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a859b721eccf311b30d0fa72b4d109
https://pubmed.ncbi.nlm.nih.gov/31539479
https://pubmed.ncbi.nlm.nih.gov/31539479
Autor:
Zining Wu, Lawrence Wolfe, Andrew R. Green, Deidre Dalmas Wilk, Neil Charter, Jak Grimes, Rita Moita Santos, Albert Isidro Llobet, Andrew M. Mason, Sapna Desai, Andrew J. Brown
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65ec38f1b8aee6acc54ec95199b3428
https://doi.org/10.1016/j.vascn.2019.05.084
https://doi.org/10.1016/j.vascn.2019.05.084