Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jaividhya Dasarathy"'
Autor:
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Anthony J Horak, Megan R McMullen, Emily Huang, Annette Bellar, Shuhui W Lorkowski, Kailash Gulshan, Robert N Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, David Streem, Ofer Reizes, Daniela S Allende, Jonathan D Smith, Judith Simcox, Laura E Nagy, J Mark Brown
Publikováno v:
eLife, Vol 12 (2024)
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 ex
Externí odkaz:
https://doaj.org/article/3c5d86faa2f749f9b1ff225029440203
Autor:
Adam Kim, Martí Ortega-Ribera, Megan R. McMullen, Annette Bellar, Moyinoluwa Taiwo, Vai Pathak, David Streem, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, Vidula Vachharajani, Laura E. Nagy
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107133- (2023)
Summary: Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also overweight, yet the molecular me
Externí odkaz:
https://doaj.org/article/d98479cccd364976b87e0478ee4d52c3
Autor:
Annette Bellar, Nicole Welch, Jaividhya Dasarathy, Amy Attaway, Ryan Musich, Avinash Kumar, Jinendiran Sekar, Saurabh Mishra, Yana Sandlers, David Streem, Laura E Nagy, Srinivasan Dasarathy
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background Patients with acute alcohol‐associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformat
Externí odkaz:
https://doaj.org/article/881a67875696428382c69cb550c103a6
Autor:
Tatsunori Miyata, Xiaoqin Wu, Xiude Fan, Emily Huang, Carlos Sanz-Garcia, Christina K. Cajigas-Du Ross, Sanjoy Roychowdhury, Annette Bellar, Megan R. McMullen, Jaividhya Dasarathy, Daniela S. Allende, Joan Caballeria, Pau Sancho-Bru, Craig J. McClain, Mack Mitchell, Arthur J. McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Laura E. Nagy
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Externí odkaz:
https://doaj.org/article/62602ca604e54c7997de01962de6b453
Autor:
Tatsunori Miyata, Xiaoqin Wu, Xiude Fan, Emily Huang, Carlos Sanz-Garcia, Christina K. Cajigas-Du Ross, Sanjoy Roychowdhury, Annette Bellar, Megan R. McMullen, Jaividhya Dasarathy, Daniela S. Allende, Joan Caballeria, Pau Sancho-Bru, Craig J. McClain, Mack Mitchell, Arthur J. McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Laura E. Nagy
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
Hepatocellular death contributes to progression of alcohol–associated (ALD-associated) and non–alcohol-associated (NAFL/NASH) liver diseases. However, receptor-interaction protein kinase 3 (RIP3), an intermediate in necroptotic cell death, contri
Externí odkaz:
https://doaj.org/article/4b33e988829949079db41f2bdafd029c
Autor:
Yana Sandlers, Rohan R. Shah, Ryan W. Pearce, Jaividhya Dasarathy, Arthur J. McCullough, Srinivasan Dasarathy
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 2, p 314 (2020)
Nonalcoholic liver disease (NAFLD) is manifested with a wide spectrum of clinical symptoms and is closely associated with the metabolic syndrome, inflammation, and mitochondrial dysfunction. Although the mechanism of mitochondrial dysfunction in NAFL
Externí odkaz:
https://doaj.org/article/002c1e8864114241a42592df9e6f672d
Autor:
Jianguo Wu, Adam Kim, Xiaoqin Wu, Semanti Ray, Daniela S. Allende, Nicole Welch, Annette Bellar, Jaividhya Dasarathy, Srinivasan Dasarathy, Laura E. Nagy
Publikováno v:
Hepatology. 77:1983-1997
Autor:
Quanri Zhang, Weiwei Liu, Katarzyna Bulek, Han Wang, Megan R. McMullen, Xiaoqin Wu, Nicole Welch, Renliang Zhang, Jaividhya Dasarathy, Srinivasan Dasarathy, Laura E. Nagy, Xiaoxia Li
Publikováno v:
Hepatology Communications. 7
Autor:
Quanri Zhang, Weiwei Liu, Katarzyna Bulek, Han Wang, Megan R. McMullen, Xiaoqin Wu, Nicole Welch, Renliang Zhang, Jaividhya Dasarathy, Srinivasan Dasarathy, Laura E. Nagy, Xiaoxia Li
Background & AimsMacrophage inducible C-type lectin (Mincle) is expressed on Kupffer cells and senses ethanol-induced danger signals released from dying hepatocytes and promotes IL-1β production. However, it remains unclear what and how ethanol-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98379ef3b0f7b3c7f50e8c90249be3a9
https://doi.org/10.1101/2022.11.30.518545
https://doi.org/10.1101/2022.11.30.518545
Autor:
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES.
Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated liver disease (AL