Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jaisri R Lingappa"'
Autor:
Brook C Barajas, Motoko Tanaka, Bridget A Robinson, Daryl J Phuong, Kasana Chutiraka, Jonathan C Reed, Jaisri R Lingappa
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006977 (2018)
During immature capsid assembly, HIV-1 genome packaging is initiated when Gag first associates with unspliced HIV-1 RNA by a poorly understood process. Previously, we defined a pathway of sequential intracellular HIV-1 capsid assembly intermediates;
Externí odkaz:
https://doaj.org/article/3f2cf88ce1c0412da13791d2d451b9bd
Autor:
Beth K Thielen, Kevin C Klein, Lorne W Walker, Mary Rieck, Jane H Buckner, Garrett W Tomblingson, Jaisri R Lingappa
Publikováno v:
PLoS Pathogens, Vol 3, Iss 9, Pp 1320-1334 (2007)
The deoxycytidine deaminase APOBEC3G (A3G) is expressed in human T cells and inhibits HIV-1 replication. When transfected into A3G-deficient epithelial cell lines, A3G induces catastrophic hypermutation by deaminating the HIV-1 genome. Interestingly,
Externí odkaz:
https://doaj.org/article/dd6a722cf18242ed8be0ae680893f899
Autor:
Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative compound fr
Externí odkaz:
https://doaj.org/article/ab895c6ab92c405ab16479c74bcf64ea
Publikováno v:
Viruses, Vol 13, Iss 3, p 451 (2021)
The concerning increase in HIV-1 resistance argues for prioritizing the development of host-targeting antiviral drugs because such drugs can offer high genetic barriers to the selection of drug-resistant viral variants. Targeting host proteins could
Externí odkaz:
https://doaj.org/article/f4c94f0e21e24b318946b9388d153204
Autor:
Anuradha F. Lingappa, Olayemi Akintunde, Connie Ewald, Markus Froehlich, Niloufar Ziari, Shao Feng Yu, Maya Michon, Suguna Mallesh, Jim Lin, Anatoliy Kitaygorodskyy, Dennis Solas, Jonathan C. Reed, Jaisri R. Lingappa, Andreas Mueller-Schiffmann, Carsten Korth, Dharma Prasad, Aysegul Nalca, Emily Ashton, Brad Fabbri, Emma Petrouski, Debendranath Dey, David Andrews, Vishwanath R. Lingappa
Two structurally-unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951, with antiviral activity in cell culture against monkeypox virus (MPXV) and human immunodeficiency virus (HIV) respectively, were studied for anti-canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1b819f47aacf2e88dedce28b0b3a974
https://doi.org/10.1101/2022.09.28.509937
https://doi.org/10.1101/2022.09.28.509937
Autor:
Andreas Müller-Schiffmann, Maya Michon, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, A. Raquel Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, M. Dharma Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa
Publikováno v:
bioRxiv
Antiviral compounds displaying several remarkable features have been identified by a uniquely enabling drug screen and advanced through validation in two animal models, and in human primary bronchial epithelial cells grown to an air-liquid interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e3f5d517503bbb152583a4089fda76
https://doi.org/10.1101/2021.01.17.426875
https://doi.org/10.1101/2021.01.17.426875
Autor:
Jonathan C. Reed, Kent Matlack, Daryl J. Phuong, J. Victor Swain, Clarence R. Hurt, Beverly Freeman, Jaisri R. Lingappa, Dennis Solas, Dylan T. B. Ressler, Anatoliy Kitaygorodskyy, Vishwanath R. Lingappa
Publikováno v:
Journal of Virology
The success of antiretroviral treatment for HIV-1 is at risk of being undermined by the growing problem of drug resistance. Thus, there is a need to identify antiretrovirals that act on viral life cycle stages not targeted by drugs in use, such as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118b8004f0c4b477c1eb1e90f47fd9d7
https://pubmed.ncbi.nlm.nih.gov/33148797
https://pubmed.ncbi.nlm.nih.gov/33148797
Publikováno v:
Viruses
Viruses, Vol 13, Iss 451, p 451 (2021)
Viruses, Vol 13, Iss 451, p 451 (2021)
The concerning increase in HIV-1 resistance argues for prioritizing the development of host-targeting antiviral drugs because such drugs can offer high genetic barriers to the selection of drug-resistant viral variants. Targeting host proteins could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bede2e4075ff9a39a692bc85918edc
https://doi.org/10.3390/v13030451
https://doi.org/10.3390/v13030451
Autor:
Kasana Chutiraka, Fadila Bouamr, Suzanne Scarlata, Sarah O'Connor, Vincent Dussupt, Kunio Nagashima, Jaisri R. Lingappa, Paola Sette, V. Siddartha Yerramilli
Publikováno v:
Cell Host & Microbe. 19:336-348
HIV-1 recruits cellular endosomal sorting complexes required for transport (ESCRTs) to bud virions from the membrane. Disruption of the viral nucleocapsid (NC) domain integrity affects HIV-1 budding. However, the molecular mechanisms of NC's involvem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0749cac327532c6a23d979a30efdf8f4
https://doi.org/10.1016/j.chom.2016.02.004
https://doi.org/10.1016/j.chom.2016.02.004
Autor:
Motoko Tanaka, Jaisri R. Lingappa, Kasana Chutiraka, Bridget A. Robinson, Jonathan C. Reed, Clair D. Geary
Publikováno v:
Journal of Virology
The major homology region (MHR) is a highly conserved motif that is found within the Gag protein of all orthoretroviruses and some retrotransposons. While it is widely accepted that the MHR is critical for assembly of HIV-1 and other retroviruses, ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a4c4a1825eb42c771cfe47b5e2ca1
https://doi.org/10.1128/jvi.02698-15
https://doi.org/10.1128/jvi.02698-15