Výsledky vyhledávání - "Jairo M. Montezuma-Rusca"

Akademický článek

Consistent Effects of Early Remdesivir on Symptoms and Disease Progression Across At-Risk Outpatient Subgroups: Treatment Effect Heterogeneity in PINETREE Study

Autor: Samuel M. Brown, Morgan J. Katz, Adit A. Ginde, Kavita Juneja, Monica Ramchandani, Joshua T. Schiffer, Carlos Vaca, Robert L. Gottlieb, Yuan Tian, Emon Elboudwarej, Joshua A. Hill, Richard Gilson, Lauren Rodriguez, Charlotte Hedskog, Shuguang Chen, Jairo M. Montezuma-Rusca, Anu Osinusi, Roger Paredes

Publikováno v: Infectious Diseases and Therapy, Vol 12, Iss 4, Pp 1189-1203 (2023)

Abstract Introduction In the PINETREE study, early remdesivir treatment reduced risk of coronavirus disease 2019 (COVID-19)-related hospitalizations or all-cause death versus placebo by 87% by day 28 in high-risk, non-hospitalized patients. Here we r

Externí odkaz: https://doaj.org/article/92c2e56adfd9476080f60f8837813ee7

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Akademický článek

Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis

Autor: Kristina N. Delgado, Jairo M. Montezuma-Rusca, Isabel C. Orbe, Melissa J. Caimano, Carson J. La Vake, Amit Luthra, Christopher M. Hennelly, Fredrick N. Nindo, Jacob W. Meyer, Letitia D. Jones, Jonathan B. Parr, Juan C. Salazar, M. Anthony Moody, Justin D. Radolf, Kelly L. Hawley

Publikováno v: mBio, Vol 13, Iss 4 (2022)

ABSTRACT The resurgence of syphilis in the new millennium has called attention to the importance of a vaccine for global containment strategies. Studies with immune rabbit serum (IRS) indicate that a syphilis vaccine should elicit antibodies (Abs) th

Externí odkaz: https://doaj.org/article/a5028a454e21422fb729d7c1f9cd8a9f

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Akademický článek

Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.

Autor: Amit Luthra, Jairo M Montezuma-Rusca, Carson J La Vake, Morgan LeDoyt, Kristina N Delgado, Timothy C Davenport, Mary Fiel-Gan, Melissa J Caimano, Justin D Radolf, Kelly L Hawley

Publikováno v: PLoS Pathogens, Vol 16, Iss 9, p e1008871 (2020)

Deconvolution of syphilis pathogenesis and selection of candidate syphilis vaccinogens requires detailed knowledge of the molecular architecture of the Treponema pallidum outer membrane (OM). The T. pallidum OM contains a low density of integral OM p

Externí odkaz: https://doaj.org/article/9f2d3a5dcca444ddb23d923afab6a67f

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Akademický článek

Simulating system dynamics of the HIV care continuum to achieve treatment as prevention.

Autor: Margaret R Weeks, David W Lounsbury, Jianghong Li, Gary Hirsch, Marcie Berman, Helena D Green, Lucy Rohena, Rosely Gonzalez, Jairo M Montezuma-Rusca, Seja Jackson

Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0230568 (2020)

The continuing HIV pandemic calls for broad, multi-sectoral responses that foster community control of local prevention and care services, with the goal of leveraging high quality treatment as a means of reducing HIV incidence. Service system improve

Externí odkaz: https://doaj.org/article/56c064615e3c46b18ad820b3cb7f4953

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Akademický článek

Early Fungicidal Activity as a Candidate Surrogate Endpoint for All-Cause Mortality in Cryptococcal Meningitis: A Systematic Review of the Evidence.

Autor: Jairo M Montezuma-Rusca, John H Powers, Dean Follmann, Jing Wang, Brigit Sullivan, Peter R Williamson

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0159727 (2016)

Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality. In clinical trials evaluating treatments for CM, biomarkers of early fungicidal activity (EFA) in cerebrospinal fluid (CSF) have been proposed as candidate surrogate endpoin

Externí odkaz: https://doaj.org/article/e29cdf519b474958a936c577e5842a19

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O01.4 The global Treponema pallidum OMPeome: a structural platform for deciphering stealth pathogenicity and developing a syphilis vaccine with worldwide efficacy

Autor: K Delgado, Jairo M. Montezuma-Rusca, Justin D. Radolf, Melissa J. Caimano, Amit Luthra, Kelly L. Hawley

Publikováno v: Oral presentations.

Background The outer membrane (OM) of Treponema pallidum (Tp) serves as the interface between the syphilis spirochete and its obligate human host and also is key to developing a vaccine with worldwide efficacy. We used structural modeling and bioinfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10a0f5fc46d3073b6c329f23e0bf7c81
https://doi.org/10.1136/sextrans-2021-sti.51

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Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine

Autor: Vladimir N. Uversky, K Delgado, Navreeta Singh, Amit Luthra, Melissa J. Caimano, Justin D. Radolf, Jairo M. Montezuma-Rusca, Kelly L. Hawley

Publikováno v: J Bacteriol

Treponema pallidum, an obligate human pathogen, has an outer membrane (OM) whose physical properties, ultrastructure, and composition differ markedly from those of phylogenetically distant Gram-negative bacteria. We developed structural models for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62823db8cdff44271031ac0789d049eb
https://pubmed.ncbi.nlm.nih.gov/34236238

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