Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jairam Palamanda"'
Autor:
Heidi J. Einolf, Barry Jones, Phillip D. Yates, Theunis C. Goosen, Diane Ramsden, Conrad Fung, Y. Amy Siu, Niresh Hariparsad, Simon Wong, Liangfu Chen, Jairam Palamanda, George Zhang, Donald J. Tweedie, Shannon Dallas
Publikováno v:
Drug Metabolism and Disposition. 49:94-110
Translational and ADME Sciences Leadership Group Induction Working Group (IWG) presents an analysis on the time course for cytochrome P450 induction in primary human hepatocytes. Induction of CYP1A2, CYP2B6, and CYP3A4 was evaluated by seven IWG labo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa020936133a247e86ba65e02dc01b76
https://doi.org/10.1124/dmd.120.000055
https://doi.org/10.1124/dmd.120.000055
Autor:
Sam V Machotka, Frank D. Sistare, Amy G. Aslamkhan, Alex M Tamburino, Todd Pippert, Raymond Evers, Kaushik Mitra, Keith Q. Tanis, Timothy E. Johnson, Donna Lynch, Wen Kang, Truyen Nguyen, Randy R. Miller, James J Monroe, Tamara D. Cabalu, Alexei A. Podtelezhnikov, Nancy G. B. Agrawal, Jairam Palamanda
Publikováno v:
Toxicological Sciences
Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2892a55e03df13402f0ef50b67f49d4b
https://doi.org/10.1093/toxsci/kfaa088
https://doi.org/10.1093/toxsci/kfaa088
Autor:
Kerry L. Fillgrove, Grace Chan, Rosa I. Sanchez, Meihong Lin, Bing Lu, Deborah J. Newton, Robert Houle, Jairam Palamanda, Kelly Bleasby
Doravirine is a novel nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 infection. In vitro studies were conducted to assess the potential for drug interactions with doravirine via major drug-metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f76b0224ecf19334aa1e470533a76d3
https://europepmc.org/articles/PMC6437506/
https://europepmc.org/articles/PMC6437506/
Autor:
Y. Amy Siu, Jairam Palamanda, Robert L. Walsky, George Zhang, David B. Buckley, Michael A. Mohutsky, Donald J. Tweedie, Liangfu Chen, Magalie Pardon, Shannon Dallas, Suresh K. Balani, Diane Ramsden, Barry Jones, Heidi J. Einolf, Jane R. Kenny, Odette A. Fahmi, Michael Sinz, Niresh Hariparsad, Joshua G. Dekeyser
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(10)
The European Medicines Agency (EMA), the Pharmaceutical and Medical Devices Agency (PMDA), and the Food and Drug Administration (FDA) have issued guidelines for the conduct of drug-drug interaction studies. To examine the applicability of these regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa706cdb57f6dcbd095aafbcf456d8b
https://pubmed.ncbi.nlm.nih.gov/28646080
https://pubmed.ncbi.nlm.nih.gov/28646080
Autor:
Milenko Cicmil, Christopher W. Boyce, Garfield G. Mingo, Hong Mei, Gissela Lieber, Yongxin Yu, Yanlin Jia, Robbie L. McLeod, Michael C. Koss, John C. Hunter, John A. Hey, Jairam Palamanda
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:75-84
Nasal congestion is one of the most troublesome symptoms of many upper airways diseases. We characterized the effect of selective α2c-adrenergic agonists in animal models of nasal congestion. In porcine mucosa tissue, compound A and compound B contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd171596e15b5ee0bcf50a1dbd403914
https://doi.org/10.1124/jpet.113.210666
https://doi.org/10.1124/jpet.113.210666
Autor:
Kelly Nulick, Niresh Hariparsad, Jane R. Kenny, Barry Jones, Donald J. Tweedie, Theunis C. Goosen, Heidi J. Einolf, Shannon Dallas, David B. Buckley, Diane Ramsden, Josh Dekeyser, George Zhang, Jairam Palamanda, Phillip D. Yates, Mike Mohutsky, Amy Siu, Simon Wong
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7344b916e04475c548063cd5258f78ba
https://doi.org/10.1016/j.dmpk.2018.09.146
https://doi.org/10.1016/j.dmpk.2018.09.146
Autor:
Michael Sinz, Jairam Palamanda, Odette A. Fahmi, Hongbing Wang, Liangfu Chen, Mohamad Shebley, Diane Ramsden, Heidi J. Einolf
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(10)
Drug-drug interactions (DDIs) due to CYP2B6 induction have recently gained prominence and clinical induction risk assessment is recommended by regulatory agencies. This work aimed to evaluate the potency of CYP2B6 versus CYP3A4 induction in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbd9f980c979a6daf67173a527cffed
https://pubmed.ncbi.nlm.nih.gov/27422672
https://pubmed.ncbi.nlm.nih.gov/27422672
Autor:
Mccormick Kevin D, Michel R. Corboz, Amin A. Nomeir, Lisa Broske, Jairam Palamanda, Walter A. Korfmacher, Xiaoying Xu, Richard Morrison, Hong Mei, Robbie L. McLeod
Publikováno v:
Drug Metabolism Letters. 4:56-61
The objectives of these studies were to characterize the pharmacokinetics (PK) of the nasal decongestant pseudoephedrine (PSE) in rats, dogs, and monkeys, and to evaluate its lower gastrointestinal tract regional bioavailability in rats. An LC-MS/MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d645e2f6b5aac1ce995373934ba13ac
https://doi.org/10.2174/187231210791292762
https://doi.org/10.2174/187231210791292762
Autor:
Michael Sinz, Liangfu Chen, Suresh K. Balani, Heidi J. Einolf, Shannon Dallas, Y. Amy Siu, Jane R. Kenny, Joshua G. Dekeyser, Robert L. Walsky, George Zhang, Michael A. Mohutsky, Jairam Palamanda, Conrad Fung, Niresh Hariparsad, Diane Ramsden, Donald J. Tweedie, David B. Buckley, Barry Jones
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S52
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0527b3902536708bbe1b78aa0923a3
https://doi.org/10.1016/j.dmpk.2017.11.178
https://doi.org/10.1016/j.dmpk.2017.11.178
Autor:
Thomas Klapmuts, Jun Chen, Er-Jia Wang, Mary Humphries, Annette S. Uss, Cindy Tran, Li Xiao, Yi-Zhong Gu, K.-C. Cheng, Pramila Kumari, Jairam Palamanda, Xinjie Lin
Publikováno v:
Drug Metabolism Letters. 3:61-66
The induction of dog CYP3A12 and CYP3A26 mRNA levels was evaluated in liver slices after treatment with 22 xenobiotics. Eleven of the 22 xenobiotics increased 3A12 mRNA by more than four-fold, while nine did the same for 3A26 mRNA. A four-fold increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c4fdca267f9f8f5fa8073fd521f266
https://doi.org/10.2174/187231209787176399
https://doi.org/10.2174/187231209787176399