Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jair L Siqueira-Neto"'
Autor:
Danya A Dean, Gautham Gautham, Jair L Siqueira-Neto, James H McKerrow, Pieter C Dorrestein, Laura-Isobel McCall
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009819 (2021)
Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is one of nineteen neglected tropical diseases. CD is a vector-borne disease transmitted by triatomines, but CD can also be transmitted through blood transfusions, organ transplants, T. c
Externí odkaz:
https://doaj.org/article/320ec1dc96c94dfa9fe6f452cffc88d9
Autor:
Isabel S Shiratsubaki, Xin Fang, Rodolpho O O Souza, Bernhard O Palsson, Ariel M Silber, Jair L Siqueira-Neto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008728 (2020)
Chagas disease is a neglected tropical disease and a leading cause of heart failure in Latin America caused by a protozoan called Trypanosoma cruzi. This parasite presents a complex multi-stage life cycle. Anti-Chagas drugs currently available are li
Externí odkaz:
https://doaj.org/article/84a796d0ce1148a1bb855932c99ffcc9
Autor:
Jacob M Wozniak, Tatiana Araújo Silva, Diane Thomas, Jair L Siqueira-Neto, James H McKerrow, David J Gonzalez, Claudia M Calvet
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0007980 (2020)
Chagas disease, the clinical presentation of T. cruzi infection, is a major human health concern. While the acute phase of Chagas disease is typically asymptomatic and self-resolving, chronically infected individuals suffer numerous sequelae later in
Externí odkaz:
https://doaj.org/article/2a60e80054e049599c289fcae6760c1f
Autor:
Jair L Siqueira-Neto, Anjan Debnath, Laura-Isobel McCall, Jean A Bernatchez, Momar Ndao, Sharon L Reed, Philip J Rosenthal
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006512 (2018)
Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive c
Externí odkaz:
https://doaj.org/article/6e7dfcafb6c748d985da28a4ff16d972
Autor:
Laura-Isobel McCall, Anupriya Tripathi, Fernando Vargas, Rob Knight, Pieter C Dorrestein, Jair L Siqueira-Neto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006344 (2018)
Trypanosoma cruzi parasites are the causative agents of Chagas disease. These parasites infect cardiac and gastrointestinal tissues, leading to local inflammation and tissue damage. Digestive Chagas disease is associated with perturbations in food ab
Externí odkaz:
https://doaj.org/article/ac6b8f77c35f40258945a77a5e6b06c1
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005519 (2016)
Externí odkaz:
https://doaj.org/article/685ac96bfad34deaab86f36c4e2f7575
Autor:
Laura-Isobel McCall, Amale El Aroussi, Jun Yong Choi, Debora F Vieira, Geraldine De Muylder, Jonathan B Johnston, Steven Chen, Danielle Kellar, Jair L Siqueira-Neto, William R Roush, Larissa M Podust, James H McKerrow
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003588 (2015)
Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are associated with significant morbidity and mortality, there are few adequate t
Externí odkaz:
https://doaj.org/article/58924484fcc34757ab91165c0f1e5fe2
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Seunghyun Moon, Jair L Siqueira-Neto, Carolina Borsoi Moraes, Gyongseon Yang, Myungjoo Kang, Lucio H Freitas-Junior, Michael A E Hansen
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87188 (2014)
We present a customized high content (image-based) and high throughput screening algorithm for the quantification of Trypanosoma cruzi infection in host cells. Based solely on DNA staining and single-channel images, the algorithm precisely segments a
Externí odkaz:
https://doaj.org/article/7df5ca7afbbf4d7e882e4c8812688470
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7302 (2024)
Cardiac fibrosis is a severe outcome of Chagas disease (CD), caused by the protozoan Trypanosoma cruzi. Clinical evidence revealed a correlation between fibrosis levels with impaired cardiac performance in CD patients. Therefore, we sought to analyze
Externí odkaz:
https://doaj.org/article/91442fd33117415994987196c79e7e5c