Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Jair L Siqueira-Neto"'
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7302 (2024)
Cardiac fibrosis is a severe outcome of Chagas disease (CD), caused by the protozoan Trypanosoma cruzi. Clinical evidence revealed a correlation between fibrosis levels with impaired cardiac performance in CD patients. Therefore, we sought to analyze
Externí odkaz:
https://doaj.org/article/91442fd33117415994987196c79e7e5c
Autor:
Jean A. Bernatchez, Yun-Seo Kil, Elany Barbosa da Silva, Diane Thomas, Laura-Isobel McCall, Karen L. Wendt, Julia M. Souza, Jasmin Ackermann, James H. McKerrow, Robert H. Cichewicz, Jair L. Siqueira-Neto
Publikováno v:
ACS Omega, Vol 7, Iss 9, Pp 7675-7682 (2022)
Externí odkaz:
https://doaj.org/article/a44ac6911af84676a0399e9101b954d0
Autor:
Danya A Dean, Gautham Gautham, Jair L Siqueira-Neto, James H McKerrow, Pieter C Dorrestein, Laura-Isobel McCall
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009819 (2021)
Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is one of nineteen neglected tropical diseases. CD is a vector-borne disease transmitted by triatomines, but CD can also be transmitted through blood transfusions, organ transplants, T. c
Externí odkaz:
https://doaj.org/article/320ec1dc96c94dfa9fe6f452cffc88d9
Autor:
Obaid Hayat, Nazif Ullah, Muhammad Sirajuddin, Miriam A. Giardini, Jennifer V. Nguyen, Karol R. Francisco, Lawrence J. Liu, Yujie Uli Sun, Svetlana Maurya, Dominic McGrosso, David J. Gonzalez, Conor R. Caffrey, Anjan Debnath, Jair L. Siqueira-Neto
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1424 (2022)
Metals have been used in medicine since ancient times for the treatment of different ailments with various elements such as iron, gold and arsenic. Metal complexes have also been reported to show antibiotic and antiparasitic activity. In this context
Externí odkaz:
https://doaj.org/article/3a11b00416ca4f92923dce5b3db08fed
Autor:
Julia M. Souza, Tatiana M. Vieira, Ana Carolina B.B. Candido, Daiane Y. Tezuka, G. Subba Rao, Sérgio de Albuquerque, Antônio E.M. Crotti, Jair L. Siqueira-Neto, Lizandra G. Magalhães
Publikováno v:
Current Research in Parasitology and Vector-Borne Diseases, Vol 1, Iss , Pp 100031- (2021)
Chagas disease is a tropical disease caused by the protozoan parasite Trypanosoma cruzi and currently affects millions of people worldwide. Curcumin (CUR), the major constituent of turmeric spice (dry powder of Curcuma longa L. plant rhizomes and roo
Externí odkaz:
https://doaj.org/article/168a9d5f74c942abb6407657d91a07c2
Autor:
Isabel S Shiratsubaki, Xin Fang, Rodolpho O O Souza, Bernhard O Palsson, Ariel M Silber, Jair L Siqueira-Neto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008728 (2020)
Chagas disease is a neglected tropical disease and a leading cause of heart failure in Latin America caused by a protozoan called Trypanosoma cruzi. This parasite presents a complex multi-stage life cycle. Anti-Chagas drugs currently available are li
Externí odkaz:
https://doaj.org/article/84a796d0ce1148a1bb855932c99ffcc9
Autor:
Jacob M Wozniak, Tatiana Araújo Silva, Diane Thomas, Jair L Siqueira-Neto, James H McKerrow, David J Gonzalez, Claudia M Calvet
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0007980 (2020)
Chagas disease, the clinical presentation of T. cruzi infection, is a major human health concern. While the acute phase of Chagas disease is typically asymptomatic and self-resolving, chronically infected individuals suffer numerous sequelae later in
Externí odkaz:
https://doaj.org/article/2a60e80054e049599c289fcae6760c1f
Autor:
Lucianna H. Santos, Thales Kronenberger, Renata G. Almeida, Elany B. Silva, Rafael E. O. Rocha, Joyce C. Oliveira, Luiza V. Barreto, Danielle Skinner, Pavla Fajtová, Miriam A. Giardini, Brendon Woodworth, Conner Bardine, André L. Lourenço, Charles S. Craik, Antti Poso, Larissa M. Podust, James H. McKerrow, Jair L. Siqueira-Neto, Anthony J. O’Donoghue, Eufrânio N. da Silva Júnior, Rafaela S. Ferreira
Publikováno v:
Journal of Chemical Information and Modeling. 62:6553-6573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b61268fbedf872a1505cd162a57177b
https://doi.org/10.1021/acs.jcim.2c00693
https://doi.org/10.1021/acs.jcim.2c00693
Autor:
Jeremy N. Rich, Charles Spruck, Xiang-Dong Fu, Lukas Chavez, Jair L. Siqueira-Neto, Xiuxing Wang, Ye Zheng, Katherine A. Jones, Zhe Zhu, Leo J.Y. Kim, Xujun Wang, Deguan Lv, Zhen Dong, Guoxin Zhang, Briana C. Prager, Jean A. Bernatchez, Deobrat Dixit, Denise Hinz, Cheryl Kim, Chunyu Jin, Shruti Bhargava, Qiyuan Yang, Ryan C. Gimple, Lihua Min, Kailin Yang, Qiulian Wu, Zhengyu Liang, Jia Z. Shen, Linjie Zhao, Zhixin Qiu
Supplementary Figures 1-7 and the figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346a13596ce65d153caefd966fa49bd2
https://doi.org/10.1158/2159-8290.22541309
https://doi.org/10.1158/2159-8290.22541309
