Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jaime Seddon"'
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Fidaxomicin was recently approved for the treatment of Clostridium difficile infection. It inhibits transcription by bacterial RNA polymerase. Because transcription is a multistep process, experiments were conducted in which fidaxomicin was added at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff56f120e2fe2f8aaf8dc9b6e4b31be2
https://doi.org/10.1093/cid/cis358
https://doi.org/10.1093/cid/cis358
Fidaxomicin (FDX) is a narrow-spectrum antibiotic for the treatment of Clostridium difficile -associated diarrhea. While FDX and rifamycins share the same target (RNA polymerase), FDX exhibits a unique mode of action distinct from that of rifamycins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c343a2a85c6b29e0d1837debf6f588
https://europepmc.org/articles/PMC3993244/
https://europepmc.org/articles/PMC3993244/
Autor:
Jaime Seddon, Farah Babakhani, A. Sarah Walker, David W Eyre, Derrick W. Crook, Carlos del Ojo Elias, Tim E. A. Peto, Sherwood L. Gorbach, David Griffiths
Publikováno v:
The Journal of Infectious Diseases
Whole-genome sequencing was used to determine whether the reductions in recurrence of Clostridium difficile infection observed with fidaxomicin in pivotal phase 3 trials occurred by preventing relapse of the same infection, by preventing reinfection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937276c8b3e4b503916b3f66790b559a
http://ora.ox.ac.uk/objects/uuid:48d7252a-3daa-44e3-b809-edf7c98d792a
http://ora.ox.ac.uk/objects/uuid:48d7252a-3daa-44e3-b809-edf7c98d792a
Publikováno v:
Antimicrobial agents and chemotherapy. 54(6)
The effects of the inoculum, pH, cation concentrations, and different lots of commercial media on the in vitro susceptibility of Clostridium difficile to fidaxomicin were examined. Of the factors evaluated, only pH alterations influenced the activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66945807ea049ff200ac23ee3f8c07d
https://pubmed.ncbi.nlm.nih.gov/20308366
https://pubmed.ncbi.nlm.nih.gov/20308366
Autor:
Chang-Hsing Liang, Po Yee Leung, Alex Romero, Sulan Yao, Chan-Kou Hwang, Pamela Sears, Yu-Hung Chiu, Yoshitaka Ichikawa, Jaime Seddon, Nicole Robert
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(5)
A series of new triazole-containing ketolides and 2-fluoro-ketolides in which the 5-O-desosamine was replaced by unnatural sugars were synthesized and evaluated against relevant macrolide-sensitive and macrolide-resistant respiratory pathogens. Excel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0257d72d65eedc19150be7a11d603e
https://pubmed.ncbi.nlm.nih.gov/15713376
https://pubmed.ncbi.nlm.nih.gov/15713376