Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Jaime Rubio"'
Autor:
Sandra Zazo, Sandra Pérez‐Buira, Nerea Carvajal, Jenifer Plaza‐Sánchez, Rebeca Manso, Nuria Pérez‐González, Carolina Dominguez, Iván Prieto‐Potin, Jaime Rubio, Manuel Dómine, Virginia Lozano, Patricia Mohedano, David Carcedo, Rafael Carias, Federico Rojo
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Objective This study aimed to describe the performance of a next‐generation sequencing (NGS) panel for the detection of precise genomic alterations in cancer in Spanish clinical practice. The impact of tumor characteristics was evaluated o
Externí odkaz:
https://doaj.org/article/f005a061fa8f46aca3f748bc4be3e83f
Autor:
Maria Nuria Peralta-Moreno, Yago Mena, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Olga Abian, Adrian Velazquez-Campoy, Timothy M. Thomson, Marta Pinto, José M. Granadino-Roldán, Maria Santos Tomas, Juan J. Perez, Jaime Rubio-Martinez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6119 (2024)
The development of specific antiviral therapies targeting SARS-CoV-2 remains fundamental because of the continued high incidence of COVID-19 and limited accessibility to antivirals in some countries. In this context, dark chemical matter (DCM), a set
Externí odkaz:
https://doaj.org/article/112df38d75b74c1394a53416a4e0597f
Autor:
Benito Farina, Ana Delia Ramos Guerra, David Bermejo-Peláez, Carmelo Palacios Miras, Andrés Alcazar Peral, Guillermo Gallardo Madueño, Jesús Corral Jaime, Anna Vilalta-Lacarra, Jaime Rubio Pérez, Arrate Muñoz-Barrutia, German R. Peces-Barba, Luis Seijo Maceiras, Ignacio Gil-Bazo, Manuel Dómine Gómez, María J. Ledesma-Carbayo
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Identifying predictive non-invasive biomarkers of immunotherapy response is crucial to avoid premature treatment interruptions or ineffective prolongation. Our aim was to develop a non-invasive biomarker for predicting immunothera
Externí odkaz:
https://doaj.org/article/399bc1686fc84f0fbfd92c6c8452620b
Autor:
Jaime Rubio-Perez, Ángel Ricardo Rodríguez-Perez, María Díaz-Blázquez, Victor Moreno-García, Manuel Dómine-Gómez
Publikováno v:
Journal of Medical Case Reports, Vol 16, Iss 1, Pp 1-7 (2022)
Abstract Background Immune checkpoint inhibitors avoid inhibition of T-cell responses, upregulating antitumor immune response. Moreover, a dysregulation with hyperactive immune response can be caused, some of them underdiagnosed. Hemophagocytic lymph
Externí odkaz:
https://doaj.org/article/2bdbdec0bb4d4f0ca971f418047aa2f4
Autor:
Maria Nuria Peralta-Moreno, Vanessa Anton-Muñoz, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Olga Abian, Adrian Velazquez-Campoy, Timothy M. Thomson, José Manuel Granadino-Roldán, Claudia Machicado, Jaime Rubio-Martinez
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 585 (2023)
Over 750 million cases of COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), have been reported since the onset of the global outbreak. The need for effective treatments has spurred intensive research for therapeuti
Externí odkaz:
https://doaj.org/article/1390327187704505aca265db9fd93a30
Autor:
Baraa Abuasaker, Eduardo Garrido, Marta Vilaplana, Jesús Daniel Gómez-Zepeda, Sonia Brun, Marta Garcia-Cajide, Caroline Mauvezin, Montserrat Jaumot, Maria Dolors Pujol, Jaime Rubio-Martínez, Neus Agell
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 748 (2023)
KRAS is the most frequently mutated oncogene associated with the genesis and progress of pancreatic, lung and colorectal (CRC) tumors. KRAS has always been considered as a therapeutic target in cancer but until now only two compounds that inhibit one
Externí odkaz:
https://doaj.org/article/b37dca4cc01e466184cf97793aaabb57
Autor:
Andrea Santos, Ion Cristóbal, Jaime Rubio, Cristina Caramés, Melani Luque, Marta Sanz-Álvarez, Sandra Zazo, Juan Madoz-Gúrpide, Federico Rojo, Jesus García-Foncillas
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12447 (2022)
The standard clinical management of locally advanced rectal cancer (LARC) patients includes neoadjuvant 5-fluorouracil (5-FU)-based chemoradiotherapy (CRT) followed by mesorectal excision. MicroRNA (miR)-19b expression levels in LARC biopsies obtaine
Externí odkaz:
https://doaj.org/article/d4c3f7b9189b48418f801bf9a4d9b2dc
Autor:
Andrea Santos, Ion Cristóbal, Jaime Rubio, Cristina Caramés, Melani Luque, Marta Sanz-Alvarez, Miriam Morales-Gallego, Juan Madoz-Gúrpide, Federico Rojo, Jesús García-Foncillas
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2203 (2022)
The identification of robust prognostic markers still represents a need in locally advanced rectal cancer (LARC). MicroRNAs (miRs) have progressively emerged as promising circulating markers, overcoming some limitations that traditional biopsy compri
Externí odkaz:
https://doaj.org/article/07e4b92d14354682a84b34289bcb034a
Publikováno v:
Polymers, Vol 13, Iss 19, p 3311 (2021)
An accurate description of the protonation state of amino acids is essential to correctly simulate the conformational space and the mechanisms of action of proteins or other biochemical systems. The pH and the electrochemical environments are decisiv
Externí odkaz:
https://doaj.org/article/ce128afdd805437895f2c112a2b653e5
Autor:
José M Granadino-Roldán, Antonia S J S Mey, Juan J Pérez González, Stefano Bosisio, Jaime Rubio-Martinez, Julien Michel
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213217 (2019)
Hit-to-lead virtual screening frequently relies on a cascade of computational methods that starts with rapid calculations applied to a large number of compounds and ends with more expensive computations restricted to a subset of compounds that passed
Externí odkaz:
https://doaj.org/article/217fcda8e93e43629c6a1c6fac7e330c