Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Jaime Rodriguez-Canales"'
Autor:
Mingchao Xie, Miljenka Vuko, Jaime Rodriguez-Canales, Johannes Zimmermann, Markus Schick, Cathy O’Brien, Luis Paz-Ares, Jonathan W. Goldman, Marina Chiara Garassino, Carl M. Gay, John V. Heymach, Haiyi Jiang, J. Carl Barrett, Ross A. Stewart, Zhongwu Lai, Lauren A. Byers, Charles M. Rudin, Yashaswi Shrestha
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background We explored potential predictive biomarkers of immunotherapy response in patients with extensive-stage small-cell lung cancer (ES-SCLC) treated with durvalumab (D) + tremelimumab (T) + etoposide-platinum (EP), D + EP, or EP in the
Externí odkaz:
https://doaj.org/article/dac90161c2bf43f78841723ad0ac6b3b
Autor:
Xiaowei Xu, Hao Wang, Michael Tetzlaff, James Ziai, Sabina Signoretti, Ashley Cimino-Mathews, Tricia Cottrell, Janis M Taube, Annikka Weissferdt, Richard A Scolyer, Pierre-Olivier Fiset, Jaime Rodriguez-Canales, Lynette M Sholl, Julie S Deutsch, Krista Chen, Carlos E de Andrea, Christine Orr, Salgado Roberto, Christian Schurch, Raja Seethala, Alexander S Baras
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/43e08721fce4413f885d76cce4d9f3a9
Autor:
Zibo Chen, Lin Zheng, Yulong Chen, Xiuxia Liu, Masanori Kawakami, Lisa Maria Mustachio, Jason Roszik, Katherine V. Ferry-Galow, Ralph E. Parchment, Xin Liu, Thorkell Andresson, Gerard Duncan, Jonathan M. Kurie, Jaime Rodriguez-Canales, Xi Liu, Ethan Dmitrovsky
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 265-280 (2022)
Cancer metastasis is a major cause of cancer-related mortality. Strategies to reduce metastases are needed especially in lung cancer, the most common cause of cancer mortality. We previously reported increased ubiquitin-specific peptidase 18 (USP18)
Externí odkaz:
https://doaj.org/article/89c6b8309f354ba2877fae72139376be
Autor:
Suzie K. Hight, Allison Mootz, Rahul K. Kollipara, Elizabeth McMillan, Paul Yenerall, Yoichi Otaki, Long-Shan Li, Kimberley Avila, Michael Peyton, Jaime Rodriguez-Canales, Barbara Mino, Pamela Villalobos, Luc Girard, Patrick Dospoy, Jill Larsen, Michael A. White, John V. Heymach, Ignacio I. Wistuba, Ralf Kittler, John D. Minna
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 8, Pp 294-310 (2020)
Using a mini-library of 1062 lentiviral shRNAs targeting 40 nuclear hormone receptors and 70 of their co-regulators, we searched for potential therapeutic targets that would be important during in vivo tumor growth using a parallel in vitro and in vi
Externí odkaz:
https://doaj.org/article/482fd373bde3424183dc0e497a6a3920
Autor:
Erminia Massarelli, Vincent K. Lam, Edwin R. Parra, Jaime Rodriguez-Canales, Carmen Behrens, Lixia Diao, Jing Wang, Jorge Blando, Lauren A. Byers, Niranjan Yanamandra, Sara Brett, Peter Morley, Padmanee Sharma, James Allison, Ignacio I. Wistuba, John V. Heymach
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Introduction OX-40 co-stimulatory signaling plays a role in mounting anti-tumor immune responses and clinical trials targeting this pathway are ongoing. However, the association of with OX-40 protein expression with clinical outcomes and pat
Externí odkaz:
https://doaj.org/article/dff5725f23a5446a81e2341a8d467be1
Autor:
Bin Shi, Carmen Behrens, Viralkumar Vaghani, Erick Marcelo Riquelme, Jaime Rodriguez‐Canales, Humam Kadara, Heather Lin, Jack Lee, Hui Liu, Ignacio Wistuba, George Simon
Publikováno v:
Cancer Medicine, Vol 8, Iss 14, Pp 6383-6392 (2019)
Abstract Background The aims of this study were to investigate the link between enhancer of zeste homolog 2 (EZH2) and histone deacetylase (HDAC) in preclinical studies and in human lung cancer tissue microarrays. Methods Enhancer of zeste homolog 2
Externí odkaz:
https://doaj.org/article/41ef1e2e42f647d58538c5ce959a2773
Autor:
Claudia Winkler, Matthew King, Julie Berthe, Domenico Ferraioli, Anna Garuti, Federica Grillo, Jaime Rodriguez-Canales, Lorenzo Ferrando, Nicolas Chopin, Isabelle Ray-Coquard, Oona Delpuech, Darawan Rinchai, Davide Bedognetti, Alberto Ballestrero, Elisabetta Leo, Gabriele Zoppoli
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Large independent analyses on cancer cell lines followed by functional studies have identified Schlafen 11 (SLFN11), a putative helicase, as the strongest predictor of sensitivity to DNA-damaging agents (DDAs), including platinum. However, its role a
Externí odkaz:
https://doaj.org/article/9b2a39fd1fd14e9b814ef38b204034e0
Autor:
Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J.A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, Jonathan M. Kurie
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109009- (2021)
Summary: Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneit
Externí odkaz:
https://doaj.org/article/2c651979e55c43638647e4def6c85ef2
Autor:
Johannes F. Fahrmann, Ichidai Tanaka, Ehsan Irajizad, Xiangying Mao, Jennifer B. Dennison, Eunice Murage, Julian Casabar, Jeffrey Mayo, Qian Peng, Muge Celiktas, Jody V. Vykoukal, Soyoung Park, Ayumu Taguchi, Oliver Delgado, Satyendra C. Tripathi, Hiroyuki Katayama, Luisa Maren Solis Soto, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio Wistuba, Samir Hanash, Edwin J. Ostrin
Publikováno v:
Cancers, Vol 14, Iss 10, p 2543 (2022)
Activation of the NRF2 pathway through gain-of-function mutations or loss-of-function of its suppressor KEAP1 is a frequent finding in lung cancer. NRF2 activation has been reported to alter the tumor microenvironment. Here, we demonstrated that NRF2
Externí odkaz:
https://doaj.org/article/7da46032bbd349bea7f5437e7dee2a8e
Autor:
Ignacio I Wistuba, Michael T Tetzlaff, Carlo B Bifulco, Katharina von Loga, Sacha Gnjatic, Scott J Rodig, Keith E Steele, Marlon C Rebelatto, Ana Lako, Guray Akturk, Michael Angelo, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Jonathan Juco, Jaime Rodriguez-Canales, Kurt A Schalper, Edward C Stack, Cláudia S Ferreira, Konstanty Korski, Emanuel Schenck, Michael J Surace
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/e9f8c04175af4728a4f0c28bb042ad00