Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jaime N Guzman"'
Autor:
Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Publikováno v:
eLife, Vol 8 (2019)
Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mech
Externí odkaz:
https://doaj.org/article/6d433a31aa0f4103a04bf72732b8b59c
Autor:
Dustin R. Wakeman, Benjamin M. Hiller, David J. Marmion, Christopher W. McMahon, Grant T. Corbett, Kile P. Mangan, Junyi Ma, Lauren E. Little, Zhong Xie, Tamara Perez-Rosello, Jaime N. Guzman, D. James Surmeier, Jeffrey H. Kordower
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 149-161 (2017)
A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of neurons that can be efficiently prepared with minimal manipulation. To address this obstacle
Externí odkaz:
https://doaj.org/article/0af637ef3a9f474e93fae6c09d34903c
Autor:
Enrico, Zampese, David L, Wokosin, Patricia, Gonzalez-Rodriguez, Jaime N, Guzman, Tatiana, Tkatch, Jyothisri, Kondapalli, William C, Surmeier, Karis B, D'Alessandro, Diego, De Stefani, Rosario, Rizzuto, Masamitsu, Iino, Jeffery D, Molkentin, Navdeep S, Chandel, Paul T, Schumacker, D James, Surmeier
Publikováno v:
Science advances. 8(39)
How do neurons match generation of adenosine triphosphate by mitochondria to the bioenergetic demands of regenerative activity? Although the subject of speculation, this coupling is still poorly understood, particularly in neurons that are tonically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::585c2e07083b4d0136f56ffe55a7cff7
https://pubmed.ncbi.nlm.nih.gov/36179023
https://pubmed.ncbi.nlm.nih.gov/36179023
Autor:
Daniel J. Galtieri, Zhong Xie, Soosung Kang, Tamara Perez-Rosello, Richard B. Silverman, Jyothisri Kondapalli, Jaime N. Guzman, D. James Surmeier, Garry Cooper, Jack Mordell
Publikováno v:
ACS Chem Biol
Ca(2+) channels with a Ca(V)1.3 pore-forming α(1) subunit have been implicated in both neurodegenerative and neuropsychiatric disorders, motivating the development of selective and potent inhibitors of Ca(V)1.3 vs Ca(V)1.2 channels, the calcium chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dfedbe893854b0294388501ad4af10
https://doi.org/10.1021/acschembio.0c00577
https://doi.org/10.1021/acschembio.0c00577
Autor:
Patricia González-Rodríguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, José López-Barneo, Paul T. Schumacker, D. James Surmeier
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In the version of this article initially published, the two bottom-left panels in Extended Data Fig. 8b duplicated the top-left and bottom-right panels of Fig. 4d presenting open field traces in mice. The panels have now been replaced with new images
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc515790d312c278eea0bb85f26bfc7
https://www.nature.com/articles/s41586-021-04382-6.pdf
https://www.nature.com/articles/s41586-021-04382-6.pdf
Autor:
Ben Yang, Ema Ilijic, Kristen A. Stout, José López-Barneo, David L. Wokosin, Michael G. Kaplitt, Jaime N. Guzman, Enrico Zampese, D. James Surmeier, Lin Gao, Paul T. Schumacker, Patricia González-Rodríguez, Mihaela Stavarache, Tatiana Tkatch
Publikováno v:
Nature
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson’s disease1. Yet, whether this change contributes to Parkinson’s disease pathogenesis is unclear2. Here we used interse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2887daece99ab9b5c17a096953927b3
http://hdl.handle.net/10261/269476
http://hdl.handle.net/10261/269476
Autor:
Zhong Xie, Garry Cooper, Daniel J. Galtieri, Richard B. Silverman, Soosung Kang, Jack Mordell, Jaime N. Guzman, Tamara Perez-Rosello, Jyothisri Kondapalli, D. James Surmeier
Publikováno v:
ACS Chemical Biology. 16:1299-1300
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e63f4e3b5008091310f9338afe5206
https://doi.org/10.1021/acschembio.1c00368
https://doi.org/10.1021/acschembio.1c00368
Autor:
Ema Ilijic, Dan Galtieri, Javier Sanchez-Padilla, David L. Wokosin, Jyothisri Kondapalli, Jaime N. Guzman, Paul T. Schumacker, D. James Surmeier, Ben Yang
Publikováno v:
Journal of Clinical Investigation. 128:2266-2280
The ability of the Cav1 channel inhibitor isradipine to slow the loss of substantia nigra pars compacta (SNc) dopaminergic (DA) neurons and the progression of Parkinson’s disease (PD) is being tested in a phase 3 human clinical trial. But it is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedc371902f147fc1268934dcedd2e53
https://doi.org/10.1172/jci95898
https://doi.org/10.1172/jci95898
Autor:
Kile P. Mangan, Dustin R. Wakeman, David J. Marmion, Zhong Xie, Benjamin M. Hiller, Jeffrey H. Kordower, Tamara Perez-Rosello, Lauren E. Little, Jaime N. Guzman, Junyi Ma, D. James Surmeier, Grant T. Corbett, Christopher W. McMahon
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 1, Pp 149-161 (2017)
Stem Cell Reports, Vol 9, Iss 1, Pp 149-161 (2017)
Summary A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of neurons that can be efficiently prepared with minimal manipulation. To address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b8039575c0d5801f845c89dae34867
http://europepmc.org/articles/PMC5511045
http://europepmc.org/articles/PMC5511045
Autor:
Ema Ilijic, Luis Carrillo-Reid, Zhong Xie, Michelle Day, Alexandria E Melendez, Jaime N. Guzman, Geraldine J. Kress, D. James Surmeier, C. Savio Chan, David L. Wokosin, Jyothisri Kondapalli, Yu Chen, Michael G. Kaplitt, Joshua L. Plotkin
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38848ec218ed201e372c187e4deb92bb
https://elifesciences.org/articles/40818
https://elifesciences.org/articles/40818