Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Jaime Mella"'
Autor:
Marcos Lorca, Gisela C. Muscia, Susana Pérez-Benavente, José M. Bautista, Alison Acosta, Cesar González, Gianfranco Sabadini, Jaime Mella, Silvia E. Asís, Marco Mellado
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 889 (2024)
Malaria is an infectious disease caused by Plasmodium spp. parasites, with widespread drug resistance to most antimalarial drugs. We report the development of two 3D-QSAR models based on comparative molecular field analysis (CoMFA), comparative molec
Externí odkaz:
https://doaj.org/article/3ca12b69adc44b4aad3a7e01a8279369
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 606 (2024)
A non-structural SARS-CoV-2 protein, PLpro, is involved in post-translational modifications in cells, allowing the evasion of antiviral immune response mechanisms. In this study, potential PLpro inhibitory drugs were designed using QSAR, molecular do
Externí odkaz:
https://doaj.org/article/96613e1ff62348889017a07c566edf24
Autor:
Juan Andrades-Lagos, Javier Campanini-Salinas, Gianfranco Sabadini, Victor Andrade, Jaime Mella, David Vásquez-Velásquez
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1621 (2023)
According to the WHO, antimicrobial resistance is among the top 10 threats to global health. Due to increased resistance rates, an increase in the mortality and morbidity of patients has been observed, with projections of more than 10 million deaths
Externí odkaz:
https://doaj.org/article/75359a3bdc5a46348b44f4f6f7d7e1ca
Autor:
Juan Andrades-Lagos, Javier Campanini-Salinas, América Pedreros-Riquelme, Jaime Mella, Duane Choquesillo-Lazarte, P. P. Zamora, Hernán Pessoa-Mahana, Ian Burbulis, David Vásquez-Velásquez
Publikováno v:
Antibiotics, Vol 12, Iss 6, p 1065 (2023)
Resistance to antibacterial agents is a growing global public health problem that reduces the efficacy of available antibacterial agents, leading to increased patient mortality and morbidity. Unfortunately, only 16 antibacterial drugs have been appro
Externí odkaz:
https://doaj.org/article/25439a23b8eb439986ae4b0546dc7220
Autor:
Ileana Araque, Javiera Ramírez, Rut Vergara, Jaime Mella, Pablo Aránguiz, Luis Espinoza, Waleska Vera, Iván Montenegro, Cristian O. Salas, Joan Villena, Mauricio A. Cuellar
Publikováno v:
Molecules, Vol 28, Iss 9, p 3959 (2023)
In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A total of 13 compounds were syn
Externí odkaz:
https://doaj.org/article/78f76b6b627d42d7b2bb87e75d18d898
Autor:
Álvaro Cañete-Molina, Christian Espinosa-Bustos, Marcos González-Castro, Mario Faúndez, Jaime Mella, Ricardo A. Tapia, Alan R. Cabrera, Iván Brito, Adam Aguirre, Cristian O. Salas
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 7, Pp 1092-1107 (2019)
We synthesized two new series of 3-substituted-6-(2,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazines and analysed them for a potential role as antitumor agents. Twenty-two compounds were obtained, and four molecular structures were determined by X-ray diff
Externí odkaz:
https://doaj.org/article/62245047d055465aa15eb2b1a71e58a5
Autor:
Jeanluc Bertrand, Hana Dostálová, Vladimír Kryštof, Radek Jorda, Thalía Delgado, Alejandro Castro-Alvarez, Jaime Mella, David Cabezas, Mario Faúndez, Christian Espinosa-Bustos, Cristian O. Salas
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1294 (2022)
We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases. The design was inspired by the chemical structur
Externí odkaz:
https://doaj.org/article/e164559cd3e445158c0980316b7a2f9f
Autor:
Marco Mellado, César González, Jaime Mella, Luis F. Aguilar, Ismail Celik, Fernanda Borges, Eugenio Uriarte, Giovanna Delogu, Dolores Viña, Maria J. Matos
Publikováno v:
Molecules, Vol 27, Iss 3, p 928 (2022)
Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in the central nervous system, as well as the production of reacti
Externí odkaz:
https://doaj.org/article/2027809adf9e4501924181c9342d01b3
Autor:
Loreto Arrieta-Rodríguez, Daniela Espinoza-Rosales, Gonzalo Vera, Young Hwa Cho, David Cabezas, David Vásquez-Velásquez, Jaime Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 528 (2021)
A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT6 receptor affinity. Eleven compounds showed moderate to high affinity at the receptor (Ki = 58–403 nM)
Externí odkaz:
https://doaj.org/article/1ab2e19e8e9c45508fb70a1c5c597cd3
Autor:
Christopher Cerda-Cavieres, Gabriel Quiroz, Patricio Iturriaga-Vásquez, Julio Rodríguez-Lavado, Jazmín Alarcón-Espósito, Claudio Saitz, Carlos D. Pessoa-Mahana, Hery Chung, Ramiro Araya-Maturana, Jaime Mella-Raipán, David Cabezas, Claudia Ojeda-Gómez, Miguel Reyes-Parada, Hernán Pessoa-Mahana
Publikováno v:
Molecules, Vol 25, Iss 20, p 4614 (2020)
A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a–o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fl
Externí odkaz:
https://doaj.org/article/ad09736e79234c8b9134bb4e5a5f08f2