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of 6
pro vyhledávání: '"Jaime L. Watson"'
Autor:
Jaime L. Watson, Pedro Gonzalez-Alegre, Michelle E. Ehrlich, Shareen Nelson, Travis B. Lewis, Maria-Daniela Cirnaru, Lisa M. Ellerby, Jordi Creus-Muncunill
Publikováno v:
Movement Disorders. 36:2780-2794
Background X-linked dystonia parkinsonism is a generalized, progressive dystonia followed by parkinsonism with onset in adulthood and accompanied by striatal neurodegeneration. Causative mutations are located in a noncoding region of the TATA-box bin
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e109099 (2014)
In humans, sensory abnormalities, including neuropathic pain, often result from traumatic spinal cord injury (SCI). SCI can induce cellular changes in the CNS, termed central sensitization, that alter excitability of spinal cord neurons, including th
Externí odkaz:
https://doaj.org/article/b5bd9ab1af314519821365803db6faef
Autor:
N. Charles Harata, Kevin A. Glenn, Pedro Gonzalez-Alegre, Jaime L. Watson, Genevieve Beauvais, Hsiang Wen, Hiroyuki Kawano, Nicole M. Bode, Michelle E. Ehrlich
Publikováno v:
The Journal of Neuroscience. 36:10245-10256
Dystonia type 1 (DYT1) is a dominantly inherited neurological disease caused by mutations inTOR1A, the gene encoding the endoplasmic reticulum (ER)-resident protein torsinA. Previous work mostly completed in cell-based systems suggests that mutant to
Autor:
Genevieve Beauvais, Jaime L. Watson, Jose A. Aguirre, Michelle E. Ehrlich, Luis Tecedor, Pedro Gonzalez-Alegre
Publikováno v:
Brain research. 1706
DYT1 dystonia is a neurological disease caused by a dominant mutation that results in the loss of a glutamic acid in the endoplasmic reticulum-resident protein torsinA. Currently, treatments are symptomatic and only provide partial relief. Multiple r
Autor:
Paul Gadue, Jaime L. Watson, Noela Rodriguez-Losada, Pedro Gonzalez-Alegre, Genevieve Beauvais, Deborah L. French, Lei Ying, Zuchra Zakirova, Ben Readhead, Michelle E. Ehrlich
Publikováno v:
Neuroscience. 371
DYT1 dystonia is a neurological disease caused by dominant mutations in the TOR1A gene, encoding for the endoplasmic reticulum (ER)-resident protein torsinA. Recent reports linked expression of the DYT1-causing protein with dysregulation of eIF2α, a
Autor:
Ken Iwatsuki, Robert F. Margolskee, Eitaro Aihara, Alexander A. Bachmanov, Jaime L. Watson, Wenwen Ren, Brian C. Lewandowski, Peihua Jiang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(46)
Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) and its homologs (e.g., Lgr6) mark adult stem cells in multiple tissues. Recently, we and others have shown that Lgr5 marks adult taste stem/progenitor cells in posterior tongue. Howe